Circular RNAs (circRNAs), non-coding RNA with stable circular covalently closed structures, provide new biomarkers for the diagnosis and treatment of various diseases and play an important role in the development of tumors. Trophoblast dysfunction can cause embryo implantation failure, placental dysplasia, and insufficient vascular remodeling at the maternal-fetal interface, leading to early pregnancy loss, preeclampsia (PE), premature delivery, and fetal growth restriction (FTR). Here, we review recent research progress in circRNAs in diseases related to trophoblast dysfunction such as PE, recurrent spontaneous abortion (RSA) and FGR. In this way, we can better understand the pathogenesis of pregnancy-related diseases and come up with new ideas for their future diagnosis and treatment.

Circular RNAs (circRNAs), non-coding RNA with stable circular covalently closed structures, provide new biomarkers for the diagnosis and treatment of various diseases and play an important role in the development of tumors. Trophoblast dysfunction can cause embryo implantation failure, placental dysplasia, and insufficient vascular remodeling at the maternal-fetal interface, leading to early pregnancy loss, preeclampsia (PE), premature delivery, and fetal growth restriction (FTR). Here, we review recent research progress in circRNAs in diseases related to trophoblast dysfunction such as PE, recurrent spontaneous abortion (RSA) and FGR. In this way, we can better understand the pathogenesis of pregnancy-related diseases and come up with new ideas for their future diagnosis and treatment.