Purpose: We aimed to investigate how genetic predisposition to drinking and gastric cancer (GC) modifies the association between alcohol consumption and GC risk in the Korean population. Materials and Methods: Polygenic risk scores for GC (PRS-GC) and alcohol consumption (PRS-Alcohol) were formulated using genome-wide association results from BioBank Japan. Validation was performed using Korean cohorts (SNUBH-GENIE cohort), incorporating 8,846 controls and 531 patients with GC. Subsequently, these PRSs were applied to an independent Korean cohort of 67,771 participants, including 313 patients with GC during the follow-up for 14 years (KoGES cohort). Results: In KoGES cohort, the influence of alcohol consumption on GC risk was significantly altered by the PRS-GC and exhibited a synergistic interaction effect. PRS-Alcohol itself shows a negative correlation with GC risk. However, when actual alcohol consumption significantly exceeded genetically predicted levels, the risk of alcohol-related GC was notably increased (adjusted hazard ratio, 1.32; 95% confidence interval, 1.01 to 1.72). Heavy drinkers in the high–PRS-GC/low–PRS-Alcohol group had a 2.16 times higher risk of GC than non-to-light drinkers, which was prominent in males. Conclusion Korean drinkers with higher PRS-GC who consume alcohol more than genetically predicted levels are susceptible to GC. PRS-GC and PRS-Alcohol may be beneficial for assessing the impact of alcohol consumption on GC risk in Koreans.

Objective: To determine the clinical significance of systematic lymph node dissection (LND) and to better define the relevant extent of LND in intermediate- to high-risk early stage endometrial cancer (EC). Methods: Patients who received surgery as a primary treatment of histologically confirmed EC and preoperatively considered as uterus-confined early stage disease were included in the study population. The rates of lymph node metastasis (LNM) according to the risk groups and anatomic sites were assessed. Univariate and multivariate analyses were performed to evaluate risk factors for recurrence. Results: A total of 804 patients were included in the study analysis. The rates of LNM were significantly different according to the risk group; 1.2% in low-risk, 20.1% in intermediate-risk, and 30.0% in high-risk group. When assessing the rates of LNM in individual anatomic sites, positive LNs were evenly distributed throughout the pelvic and para-aortic regions. In the intermediate to high-risk EC cases, the rates of para-aortic LNM below and above inferior mesenteric artery (IMA) were 11.1% and 12.5%, respectively. On multivariate analysis, LNM was the only independent risk factor for recurrence in the intermediate to high-risk EC (hazard ratio=2.63, 95% confidence interval=1.01–6.82, p=0.047). Conclusion LNM was frequently observed in intermediate- and high-risk early stage EC and it served as an independent risk factor for recurrence. When considering the similar rates of LNM between below and above IMA, nodal assessment needs to be performed up to the infra-renal level, especially for the staging purpose in high-risk EC.

Purpose: Retroperitoneal (RP) abscess is a rare condition with poor prognosis, unclear etiology, characteristics, and treatment. This study compared transperitoneal and RP approach methods in the treatment of RP abscess. Methods: There were 45 patients with RP abscess diagnosed at Inha University Hospital from January 2014 to August 2018, of which 22 patients with 2 RP zones and systemic inflammatory response syndrome were included. Characteristics, etiology, laboratory and radiological findings, surgical technique, complications, and total number of hospital days were examined. Patients were assigned to either the transperitoneal (TP) or RP approach group. Results: There were 22 patients with RP abscess who were treated with surgical drainage using either the TP (n = 13) or RP (n = 9) approach. There was no difference in characteristics between the 2 groups. The number of reinterventions in the RP group (n = 6) was more than in the TP group (n = 4; p = 0.02). Mortality in the TP group (n = 5) was higher than in the RP group (n = 1; p < 0.01). The total mean number of hospital days in the RP group (mean: 76, range: 29-180 days) was more than in the TP group (mean: 58, range: 18-280 days, p = 0.03). Conclusion RP abscess requires rapid drainage using the TP or RP approach. Reintervention events and number of hospital days in the RP group was greater than the TP group; however, mortality in the RP group was lower than in the TP group.

Purpose: Retroperitoneal (RP) abscess is a rare condition with poor prognosis, unclear etiology, characteristics, and treatment. This study compared transperitoneal and RP approach methods in the treatment of RP abscess. Methods: There were 45 patients with RP abscess diagnosed at Inha University Hospital from January 2014 to August 2018, of which 22 patients with 2 RP zones and systemic inflammatory response syndrome were included. Characteristics, etiology, laboratory and radiological findings, surgical technique, complications, and total number of hospital days were examined. Patients were assigned to either the transperitoneal (TP) or RP approach group. Results: There were 22 patients with RP abscess who were treated with surgical drainage using either the TP (n = 13) or RP (n = 9) approach. There was no difference in characteristics between the 2 groups. The number of reinterventions in the RP group (n = 6) was more than in the TP group (n = 4; p = 0.02). Mortality in the TP group (n = 5) was higher than in the RP group (n = 1; p < 0.01). The total mean number of hospital days in the RP group (mean: 76, range: 29-180 days) was more than in the TP group (mean: 58, range: 18-280 days, p = 0.03). Conclusion RP abscess requires rapid drainage using the TP or RP approach. Reintervention events and number of hospital days in the RP group was greater than the TP group; however, mortality in the RP group was lower than in the TP group.

Objective: This study aimed to evaluate the effect of cognitive training programs on the progression of dementia in patients with early stage Alzheimer’s disease dementia (ADD) at the day care center. Methods: From January 2015 to December 2018, a total of 119 patients with early ADD were evaluated. All subjects were classified into two groups according to participate in cognitive training program in addition to usual standard clinical care. Changes in scores for minimental status examination-dementia screening (MMSE-DS) and clinical dementia rating-sum of boxes (CDR-SOB) during the 12 months were compared between two groups. Multivariable logistic regression analyses were performed. Results: As compared to case-subjects (n=43), the MMSE-DS and CDR-SOB scores were significantly worse at 12 months in the control-subjects (n=76). A statistically significant difference between the two groups was observed due to changes in MMSE-DS (p=0.012) and CDR-SOB (p<0.001) scores. Multivariable logistic regression analysis showed that the cognitive training program (odds ratio and 95% confidence interval: 0.225, 0.070–0.725) was independently associated with less progression of ADD. Conclusion The cognitive training program was associated with benefits in maintaining cognitive function for patients with earlystage ADD that were receiving medical treatment.

No abstract available.