1.Identifying early risk factors for chronic pain development following vertebral fractures: a single-center prospective cohort study
Yutaro KONDO ; Hideki KATAOKA ; Kyo GOTO ; Koichi NAKAGAWA ; Yutaro NOMOTO ; Junichiro YAMASHITA ; Kaoru MORITA ; Nobuya ASO ; Yuki NSHI ; Junya SAKAMOTO ; Minoru OKITA
Asian Spine Journal 2025;19(6):928-938
Methods:
Hospitalized patients with acute VFs underwent assessment of vertebral morphology and paraspinal muscles. Two weeks post-admission, patients were evaluated for pain intensity (using the Verbal Rating Scale [VRS]), pain sensitivity (Pressure Pain Threshold [PPT] and Conditioned Pain Modulation), psychological factors, physical function, and activity levels. At 12 weeks, patients were categorized into CP and non-CP (NCP) groups based on VRS scores. Between-group comparisons and logistic regression analysis were performed to identify predictors of CP development.
Results:
The CP group exhibited significantly lower remote PPT and reduced low-intensity physical activity time, but higher Pain Catastrophizing Scale rumination scores and prolonged 5-Times Sit-to-Stand Test (5SST) compared to the NCP group. Logistic regression identified prolonged 5SST and reduced low-intensity physical activity as independent predictors of CP development.
Conclusions
Prolonged 5SST and reduced low-intensity physical activity may predict CP development after VFs. Early assessment of these factors may facilitate CP risk screening in hospitalized patients with VFs.
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