Systemic lupus erythematosus(SLE)is a chronic autoimmune disease with complex etiology and diverse clinical manifestations.Its pathogenesis is complex,and the clinical treatment effect is not yet ide-al.Lipids are precursors of bioactive metabolites and components of cell membranes,exerting direct and indi-rect regulatory effects on signal transduction,gene regulation,and cell activation.Furthermore,lipids are one of the most significantly changing biomarkers in the serum of SLE patients.This article reviews the abnormal manifestations of lipid metabolism in SLE,the regulation of lipid metabolism and immune cell function,and possible therapeutic applications,providing new ideas for the diagnosis and treatment of SLE.

Heart failure,as a global public health challenge,is experiencing an increasingly severe disease burden.Given the close relationship be-tween the Nitric Oxide-Soluble Guanylate Cyclase-Cyclic Guanosine Monophosphate(NO-sGC-cGMP)signaling pathway and heart failure,this study,through a comprehensive search and review of re-cent literature on the NO-sGC-cGMP pathway and heart failure,aims to outline the mechanism of ac-tion of this signaling pathway and its connection with heart failure,in order to explore new avenues for the treatment of heart failure.

Heart failure,as a global public health challenge,is experiencing an increasingly severe disease burden.Given the close relationship be-tween the Nitric Oxide-Soluble Guanylate Cyclase-Cyclic Guanosine Monophosphate(NO-sGC-cGMP)signaling pathway and heart failure,this study,through a comprehensive search and review of re-cent literature on the NO-sGC-cGMP pathway and heart failure,aims to outline the mechanism of ac-tion of this signaling pathway and its connection with heart failure,in order to explore new avenues for the treatment of heart failure.