Objective:To explore effects of cardiac exercise rehabilitation combined with mindfulness music training on patients with acute myocardial infarction after percutaneous coronary intervention (PCI) .Methods:Using the convenient sampling method, a total of 126 patients with acute myocardial infarction who received PCI treatment at Pingdingshan the Second People's Hospital from February 2018 to January 2021 were selected as the research objects. According to the random number table method, they were divided into two groups, with 63 cases in each group. The control group received routine care, and the observation group received cardio exercise rehabilitation combined with mindfulness music training on the basis of routine care. The left ventricular ejection fraction (LVEF), stroke volume (SV) and cardiac output (CO) were used to compare the cardiac function of patients in the two groups. Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD) and Pittsburgh Sleep Quality Index (PSQI) were used to compare the negative emotions and sleep quality of patients in the two groups.Results:After the intervention for 1 and 3 months, LVEF, SV and CO of the observation group were higher than those of the control group, and the differences were statistically significant ( P<0.05). After the intervention for 1 and 3 months, HAMA, HAMD and PSQI scores of the observation group were lower than those of the control group, and the differences were statistically significant ( P<0.05) . Conclusions:The application of cardiac exercise rehabilitation combined with mindfulness music training in patients with acute myocardial infarction after PCI is beneficial to improve heart function and relieve adverse psychological stress of patients.