We report a case of bilateral hand complications following Artecoll injections that were successfully managed with surgical excision and reconstruction using MatriDerm and split-thickness skin grafts. Notably, the patient experienced no postoperative foreign body reactions and achieved excellent functional outcomes, with a complete range of motion at 3.5 years postoperatively. This case underscores the effectiveness of MatriDerm-assisted reconstruction in achieving both functional and aesthetic results.

We report a case of bilateral hand complications following Artecoll injections that were successfully managed with surgical excision and reconstruction using MatriDerm and split-thickness skin grafts. Notably, the patient experienced no postoperative foreign body reactions and achieved excellent functional outcomes, with a complete range of motion at 3.5 years postoperatively. This case underscores the effectiveness of MatriDerm-assisted reconstruction in achieving both functional and aesthetic results.

We report a case of bilateral hand complications following Artecoll injections that were successfully managed with surgical excision and reconstruction using MatriDerm and split-thickness skin grafts. Notably, the patient experienced no postoperative foreign body reactions and achieved excellent functional outcomes, with a complete range of motion at 3.5 years postoperatively. This case underscores the effectiveness of MatriDerm-assisted reconstruction in achieving both functional and aesthetic results.

Purpose: To identify factors associated with retinal tears in eyes presenting with fundus-obscuring vitreous hemorrhage (FOVH) of unknown cause and to evaluate surgical findings and visual outcomes following pars plana vitrectomy (PPV). Methods: This retrospective study included patients who underwent 23-gauge or 25-gauge PPV for acute-onset FOVH, defined as a dense vitreous hemorrhage obscuring both the posterior pole and peripheral retina across at least three quadrants with a best-corrected visual acuity (BCVA) of counting fingers or worse at presentation. Etiologies of FOVH were identified intraoperatively, and subsequent analyses focused on the prevalence, clinical characteristics, and surgical outcomes of eyes diagnosed with retinal tears. Results: Among the 8 9 eyes in cluded, retinal tears were the most common etiology (38.2%), followed by retinal vascular occlusion (27.0%), and polypoidal choroidal vasculopathy (13.5%). Eyes with retinal tears were significantly younger (57.2 vs. 67.9 years, p <0.001) and less likely to have diabetes (5.9 vs. 41.8%, p <0.001) compared with those without retinal tears. In a multivariate analysis, younger age (p < 0.001) and absence of diabetes (p = 0.007) were independent predictors of retinal tears. Among eyes with retinal tears, the mean duration from symptom onset to surgery was 9.2 days. Most eyes (67.6%) had a single tear, and in 79.4%, the largest tear was in the superior quadrant. No cases of macular-off retinal detachment or proliferative vitreoretinopathy were observed. At final follow-up, 82.4% of the eyes achieved a BCVA of 20/20, with no cases of reoperation. Conclusions Retinal tears are commonly identified intraoperatively in eyes presenting with FOVH, with younger age and absence of diabetes significantly associated with their presence. Despite delayed surgery, favorable anatomical and visual outcomes were achieved.Given the frequent localization of tears in the superior retina, careful peripheral inspection during vitrectomy is essential for detecting treatable pathology.

Purpose: This study aimed to develop a deep learning regression model using macular optical coherence tomography (OCT) images to predict estimated glomerular filtration rate (eGFR). Methods: In this retrospective cross-sectional study, we analyzed data from patients who underwent preoperative evaluation for cataract surgery, including spectral-domain OCT (Spectralis; Heidelberg Engineering) images, blood test–derived eGFR, and ocular biometry.A dual-input regression model based on a modified ResNet-18 architecture was constructed to process simultaneously horizontal and vertical B-scan macular OCT images. The model’s predicted eGFR was further combined with patient age, sex, presence of diabetes and hypertension, and axial length using a Random Forest regression algorithm to create a hybrid model. Model performance was assessed using the root mean squared error (RMSE) and coefficient of determination (R2 ). Gradient-weighted regression activation mapping (GradRAM) was applied for visualization to assess the anatomical regions contributing to predictions. Results: A total of 101 eyes from 101 patients were included. The ResNet-18 model achieved an eGFR prediction accuracy with an R2of 0.89 and an RMSE of 4.23. The Random Forest hybrid model further improved predictive performance, achieving an R2 of 0.94 and an RMSE of 3.64. The mean absolute error (MAE) across the full cohort was 3.69 ± 2.08 mL/min/1.73 m2 . Among the 10 most accurately predicted cases, the MAE was as low as 0.42 ± 0.20 mL/min/1.73 m2 , while the 10 least accurate cases showed an MAE of 7.44 ± 0.92 mL/ min/1.73 m2 . Grad-RAM visualizations revealed predominant activation in the choroidal region of vertical OCT images. Conclusions This is the first study to demonstrate accurate prediction of renal function from macular OCT images using deep learning.The dual-input architecture and Grad-RAM visualization enabled high prediction performance and partial anatomical interpretability.These findings support the potential of OCT-based oculomics for systemic disease assessment.

Although lipoma is a well-known non-malignant tumor, oral cavity lipoma is a rather uncommon disease. Intraoral lipoma originating from the buccal fat pad is an exceptionally rare disorder. Buccal fat pad lipomas typically impair the face's appearance and functionality. The treatment is surgical excision using an intraoral technique, and close identifying of the surrounding anatomical systems, including the parotid duct, vessels, and buccinator branch of the facial nerve. A fifty-year-old patient reported consistently growing swelling of the left cheek. Clinical examination revealed a unilateral mass in the soft tissue. An MRI scan showed a typical picture of a lipoma attached to the buccal fat pad. Surgery was performed to remove the tumor, and the histology report confirmed the clinical diagnosis of lipoma.

Although lipoma is a well-known non-malignant tumor, oral cavity lipoma is a rather uncommon disease. Intraoral lipoma originating from the buccal fat pad is an exceptionally rare disorder. Buccal fat pad lipomas typically impair the face's appearance and functionality. The treatment is surgical excision using an intraoral technique, and close identifying of the surrounding anatomical systems, including the parotid duct, vessels, and buccinator branch of the facial nerve. A fifty-year-old patient reported consistently growing swelling of the left cheek. Clinical examination revealed a unilateral mass in the soft tissue. An MRI scan showed a typical picture of a lipoma attached to the buccal fat pad. Surgery was performed to remove the tumor, and the histology report confirmed the clinical diagnosis of lipoma.

Rare endocrine diseases are complex conditions that require lifelong specialized care due to their chronic nature and associated long-term complications. In Korea, a lack of nationwide data on clinical practice and outcomes has limited progress in patient care. Therefore, the Multicenter Networks for Ideal Outcomes of Pediatric Rare Endocrine and Metabolic Disease (OUTSPREAD) study was initiated. This study involves 30 centers across Korea. The study aims to improve the long-term prognosis of Korean patients with rare endocrine diseases by collecting comprehensive clinical data, biospecimens, and patient-reported outcomes to identify complications and unmet needs in patient care. Patients with childhood-onset pituitary, adrenal, or gonadal disorders, such as craniopharyngioma, congenital adrenal hyperplasia (CAH), and Turner syndrome were prioritized. The planned enrollment is 1,300 patients during the first study phase (2022–2024). Clinical, biochemical, and imaging data from diagnosis, treatment, and follow-up during 1980–2023 were retrospectively reviewed. For patients who agreed to participate in the prospective cohort, clinical data and biospecimens will be prospectively collected to discover ideal biomarkers that predict the effectiveness of disease control measures and prognosis. Patient-reported outcomes, including quality of life and depression scales, will be evaluated to assess psychosocial outcomes. Additionally, a substudy on CAH patients will develop a steroid hormone profiling method using liquid chromatography-tandem mass spectrometry to improve diagnosis and monitoring of treatment outcomes. This study will address unmet clinical needs by discovering ideal biomarkers, introducing evidence-based treatment guidelines, and ultimately improving long-term outcomes in the areas of rare endocrine and metabolic diseases.

Rare endocrine diseases are complex conditions that require lifelong specialized care due to their chronic nature and associated long-term complications. In Korea, a lack of nationwide data on clinical practice and outcomes has limited progress in patient care. Therefore, the Multicenter Networks for Ideal Outcomes of Pediatric Rare Endocrine and Metabolic Disease (OUTSPREAD) study was initiated. This study involves 30 centers across Korea. The study aims to improve the long-term prognosis of Korean patients with rare endocrine diseases by collecting comprehensive clinical data, biospecimens, and patient-reported outcomes to identify complications and unmet needs in patient care. Patients with childhood-onset pituitary, adrenal, or gonadal disorders, such as craniopharyngioma, congenital adrenal hyperplasia (CAH), and Turner syndrome were prioritized. The planned enrollment is 1,300 patients during the first study phase (2022–2024). Clinical, biochemical, and imaging data from diagnosis, treatment, and follow-up during 1980–2023 were retrospectively reviewed. For patients who agreed to participate in the prospective cohort, clinical data and biospecimens will be prospectively collected to discover ideal biomarkers that predict the effectiveness of disease control measures and prognosis. Patient-reported outcomes, including quality of life and depression scales, will be evaluated to assess psychosocial outcomes. Additionally, a substudy on CAH patients will develop a steroid hormone profiling method using liquid chromatography-tandem mass spectrometry to improve diagnosis and monitoring of treatment outcomes. This study will address unmet clinical needs by discovering ideal biomarkers, introducing evidence-based treatment guidelines, and ultimately improving long-term outcomes in the areas of rare endocrine and metabolic diseases.

Although lipoma is a well-known non-malignant tumor, oral cavity lipoma is a rather uncommon disease. Intraoral lipoma originating from the buccal fat pad is an exceptionally rare disorder. Buccal fat pad lipomas typically impair the face's appearance and functionality. The treatment is surgical excision using an intraoral technique, and close identifying of the surrounding anatomical systems, including the parotid duct, vessels, and buccinator branch of the facial nerve. A fifty-year-old patient reported consistently growing swelling of the left cheek. Clinical examination revealed a unilateral mass in the soft tissue. An MRI scan showed a typical picture of a lipoma attached to the buccal fat pad. Surgery was performed to remove the tumor, and the histology report confirmed the clinical diagnosis of lipoma.