A 77-year-old male patient received intravenous infusion of levofloxacin 0.5 g for preventing infection before transrectal prostate biopsy. Three hours after the infusion finished, erythema with pruritus appeared on his trunk, buttocks and limbs. Two days later, the patient developed fever, aggravated rash, and large area of blisters. Three days later, the blisters were broken and Nikolsky sign was positive. Toxic epidermal necrolysis was diagnosed, which was considered to be related to levofloxacin. Symptomatic treatments including combination use of glucocorticoid and human immunoglobulin and skin wound care were given. Fifteen days later, his rash completely subsided and the skin wound healed basically.

A 77-year-old male patient received intravenous infusion of levofloxacin 0.5 g for preventing infection before transrectal prostate biopsy. Three hours after the infusion finished, erythema with pruritus appeared on his trunk, buttocks and limbs. Two days later, the patient developed fever, aggravated rash, and large area of blisters. Three days later, the blisters were broken and Nikolsky sign was positive. Toxic epidermal necrolysis was diagnosed, which was considered to be related to levofloxacin. Symptomatic treatments including combination use of glucocorticoid and human immunoglobulin and skin wound care were given. Fifteen days later, his rash completely subsided and the skin wound healed basically.