The common data model (CDM) has found widespread application in healthcare studies, but its utilization in cancer research has been limited. This article describes the development and implementation strategy for Cancer Clinical Library Databases (CCLDs), which are standardized cancer-specific databases established under the Korea-Clinical Data Utilization Network for Research Excellence (K-CURE) project by the Korean Ministry of Health and Welfare. Fifteen leading hospitals and fourteen academic associations in Korea are engaged in constructing CCLDs for 10 primary cancer types. For each cancer type-specific CCLD, cancer data experts determine key clinical data items essential for cancer research, standardize these items across cancer types, and create a standardized schema. Comprehensive clinical records covering diagnosis, treatment, and outcomes, with annual updates, are collected for each cancer patient in the target population, and quality control is based on six-sigma standards. To protect patient privacy, CCLDs follow stringent data security guidelines by pseudonymizing personal identification information and operating within a closed analysis environment. Researchers can apply for access to CCLD data through the K-CURE portal, which is subject to Institutional Review Board and Data Review Board approval. The CCLD is considered a pioneering standardized cancer-specific database, significantly representing Korea’s cancer data. It is expected to overcome limitations of previous CDMs and provide a valuable resource for multicenter cancer research in Korea.

The common data model (CDM) has found widespread application in healthcare studies, but its utilization in cancer research has been limited. This article describes the development and implementation strategy for Cancer Clinical Library Databases (CCLDs), which are standardized cancer-specific databases established under the Korea-Clinical Data Utilization Network for Research Excellence (K-CURE) project by the Korean Ministry of Health and Welfare. Fifteen leading hospitals and fourteen academic associations in Korea are engaged in constructing CCLDs for 10 primary cancer types. For each cancer type-specific CCLD, cancer data experts determine key clinical data items essential for cancer research, standardize these items across cancer types, and create a standardized schema. Comprehensive clinical records covering diagnosis, treatment, and outcomes, with annual updates, are collected for each cancer patient in the target population, and quality control is based on six-sigma standards. To protect patient privacy, CCLDs follow stringent data security guidelines by pseudonymizing personal identification information and operating within a closed analysis environment. Researchers can apply for access to CCLD data through the K-CURE portal, which is subject to Institutional Review Board and Data Review Board approval. The CCLD is considered a pioneering standardized cancer-specific database, significantly representing Korea’s cancer data. It is expected to overcome limitations of previous CDMs and provide a valuable resource for multicenter cancer research in Korea.

The common data model (CDM) has found widespread application in healthcare studies, but its utilization in cancer research has been limited. This article describes the development and implementation strategy for Cancer Clinical Library Databases (CCLDs), which are standardized cancer-specific databases established under the Korea-Clinical Data Utilization Network for Research Excellence (K-CURE) project by the Korean Ministry of Health and Welfare. Fifteen leading hospitals and fourteen academic associations in Korea are engaged in constructing CCLDs for 10 primary cancer types. For each cancer type-specific CCLD, cancer data experts determine key clinical data items essential for cancer research, standardize these items across cancer types, and create a standardized schema. Comprehensive clinical records covering diagnosis, treatment, and outcomes, with annual updates, are collected for each cancer patient in the target population, and quality control is based on six-sigma standards. To protect patient privacy, CCLDs follow stringent data security guidelines by pseudonymizing personal identification information and operating within a closed analysis environment. Researchers can apply for access to CCLD data through the K-CURE portal, which is subject to Institutional Review Board and Data Review Board approval. The CCLD is considered a pioneering standardized cancer-specific database, significantly representing Korea’s cancer data. It is expected to overcome limitations of previous CDMs and provide a valuable resource for multicenter cancer research in Korea.

Recently, oriental treatments, including facial asymmetry correction, skin elasticity enhancement, and scar treatment, have been increasingly used for cosmetic purposes. These treatments include moxibustion and various acupunctures including thread-embedding therapy. Herein, we report two cases of facial scar development following moxibustion for acne scars and thread-embedding therapy for correcting nose shape in an Oriental medical clinic aiming to raise awareness about the adverse dermatological effects of oriental treatments for cosmetic purposes.

Recently, oriental treatments, including facial asymmetry correction, skin elasticity enhancement, and scar treatment, have been increasingly used for cosmetic purposes. These treatments include moxibustion and various acupunctures including thread-embedding therapy. Herein, we report two cases of facial scar development following moxibustion for acne scars and thread-embedding therapy for correcting nose shape in an Oriental medical clinic aiming to raise awareness about the adverse dermatological effects of oriental treatments for cosmetic purposes.

Recently, oriental treatments, including facial asymmetry correction, skin elasticity enhancement, and scar treatment, have been increasingly used for cosmetic purposes. These treatments include moxibustion and various acupunctures including thread-embedding therapy. Herein, we report two cases of facial scar development following moxibustion for acne scars and thread-embedding therapy for correcting nose shape in an Oriental medical clinic aiming to raise awareness about the adverse dermatological effects of oriental treatments for cosmetic purposes.

Recently, oriental treatments, including facial asymmetry correction, skin elasticity enhancement, and scar treatment, have been increasingly used for cosmetic purposes. These treatments include moxibustion and various acupunctures including thread-embedding therapy. Herein, we report two cases of facial scar development following moxibustion for acne scars and thread-embedding therapy for correcting nose shape in an Oriental medical clinic aiming to raise awareness about the adverse dermatological effects of oriental treatments for cosmetic purposes.

Background: Various treatment methods for facial skin anti-aging remain challenging. Objective: To evaluate the efficacy and safety of a high/low-frequency ultrasound with a skin conditioning topical serum to improve skin conditions. Methods: A total of twenty healthy Korean participants aged 30∼65 years were recruited. Each participant was treated by a high/low-frequency ultrasound device (CIELO; Staronic) with a skin conditioning serum twice per week for 4 weeks during nine visits. Photographs of each participant were taken at baseline, before each treatment session, and 4 weeks after the last treatment using an imaging tool (Mark-Vu; PSI PLUS). Two-blinded independent evaluators assessed the results using the Physician Global Aesthetic Improvement Scale (PGAIS). Melanin index (MI) and erythema index (EI) were evaluated using a mexameter. Transepidermal water loss (TEWL) was evaluated using a tewameter. Stratum corneum water content was evaluated using a corneometer. Participant satisfaction and adverse events were observed. Results: MI, EI, TEWL, and stratum corneum water content significantly improved at the ninth visit. A clinical improvement in the PGAIS was observed in 40% (8/20) of participants, and 75% (15/20) of participants reported a high satisfaction score. Conclusion High/low-frequency ultrasound combined with a regenerative serum is a potentially safe and effective option for facial skin anti-aging therapy.

Background: Botulinum toxin type A (BTX-A) injection is being widely used off-label for muscular hypertrophy, including deltoid muscle hypertrophy. However, very few studies have evaluated the optimal dosage and its clinical response. Objective: This study aimed to assess the efficacy and safety of different doses of Prabotulinum toxin A (PBoNT) for treating deltoid muscle hypertrophy. Methods: Twelve particiapants with bilateral deltoid muscle hypertrophy were enrolled and randomly received either 16 U or 32 U of PBoNT. In each participant, the same dose was administered to both deltoid muscles. Both participants and evaluators were blinded. Deltoid muscle thickness and upper arm circumference were measured on day 0, and weeks 2, 4, and 12 after the PBoNT injection. Results: Upper arm circumference significantly decreased in both groups; however, deltoid muscle thickness was reduced in the 16 U group only. No major complications were reported in both groups. However, a few minor complications were reported in the 16 U injection group. Conclusion Both 16 U and 32 U of PBoNT intramuscular injections are safe and effective in treating deltoid hypertrophy.

Background: Airborne particulate matter (PM), a widespread air contaminant, is a complex mixture of solids and aerosols composed of particles suspended in the air. PM is associated with inflammatory responses and may worsen inflammatory skin diseases. However, the mechanisms through which PM affects atopic dermatitis (AD) remain unclear. Objective: To establish an In Vitro model that more accurately mimics AD using human keratinocyte (HaCaT), dermal fibroblast (HDF), and mast cell (HMC-1) and using this model to investigate the mechanism through which PMs affect AD. Methods: An AD-like In Vitro model was established by seeding HaCaT, HDF, and HMC-1 cells with recombinant human interleukin (IL)-1α and polyinosinic:polycytidylic acid.We confirmed the effect of PM on the inflammatory cytokine expression of a triple-cell culture model. SRM 1649b Urban Dust, which is mainly composed of polycyclic aromatic hydrocarbons, was used as the reference PM. The effects of PM on the expression levels of proinflammatory cytokines and skin barrier markers were assessed using quantitative real-time polymerase chain reaction and western blotting. Inflammatory cytokine levels were measured using an enzyme-linked immunosorbent assay. Results: Interactions between various skin cell types were evaluated using a co-culture system. PM treatment increased mRNA and protein levels of the inflammatory cytokines IL-6, IL-1α, tumor necrosis factor-α, IL-4, and IL-1β and decreased the expression of the skin barrier markers filaggrin and loricrin. Conclusion Our results suggest that an In Vitro triple-cell culture model using HaCaT, HDF, and HMC-1 cells may be reliable for obtaining more physiological, functional, and reproducible data on AD and skin barriers.