Objective:To explore the predictive value of triglyceride-glucose (TyG) index combined with low-density lipoprotein cholesterol (LDL-C) for major adverse cardiovascular events (MACE) in patients with coronary heart disease (CHD) complicated by type 2 diabetes mellitus (T2DM).Methods:A total of 248 patients with CHD and T2DM admitted to the First Affiliated Hospital of Xinjiang Medical University from July 2022 to January 2024 were retrospectively enrolled. All patients were followed up for 2 years and divided into MACE group (43 cases) and non-MACE group (205 cases) according to the occurrence of MACE. Indicators such as TyG index and LDL-C were compared between the two groups, and their correlations with MACE were analyzed. Multivariate logistic regression was used to screen the risk factors for MACE in patients with CHD and T2DM. Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of TyG index, LDL-C, and their combination for MACE in these patients.Results:Compared with the non-MACE group, the MACE group had significantly higher LDL-C [2.63(2.23, 2.95)mmol/L vs 1.99(1.60, 2.66)mmol/L, P<0.001] and TyG index [9.30(8.80, 9.87) vs 8.60(8.09, 9.15), P<0.001]. Multivariate logistic regression showed that TyG index was an independent risk factor for MACE in patients with CHD and T2DM ( OR=10.49, P<0.001). ROC curve results indicated that the area under the curve (AUC) of TyG index and LDL-C for predicting MACE were 0.731 and 0.686, respectively. The combined AUC of the two indicators for predicting MACE was 0.769(95% CI: 0.698-0.840), showing better predictive performance. Conclusions:TyG index combined with LDL-C has high predictive value for the risk of MACE in patients with CHD complicated by T2DM.

Diabetic cardiomyopathy is a heart disease characterized by abnormal myocardial structure and function caused by long-term hyperglycemic levels, and its characteristic pathological change is left ventricular hypertrophy. Studies have shown that the incidence of left ventricular hypertrophy is relatively high in patients with diabetes, and left ventricular hypertrophy has a negative impact on cardiac function, leading to the occurrence and deterioration of heart failure. This review aims to clarify the mechanism of left ventricular hypertrophy in patients with diabetic cardiomyopathy and explore the prevention of the development of centripetal failure in diabetic cardiomyopathy through intervention in left ventricular hypertrophy.

Diabetic cardiomyopathy is a heart disease characterized by abnormal myocardial structure and function caused by long-term hyperglycemic levels, and its characteristic pathological change is left ventricular hypertrophy. Studies have shown that the incidence of left ventricular hypertrophy is relatively high in patients with diabetes, and left ventricular hypertrophy has a negative impact on cardiac function, leading to the occurrence and deterioration of heart failure. This review aims to clarify the mechanism of left ventricular hypertrophy in patients with diabetic cardiomyopathy and explore the prevention of the development of centripetal failure in diabetic cardiomyopathy through intervention in left ventricular hypertrophy.

Objective:To explore the predictive value of triglyceride-glucose (TyG) index combined with low-density lipoprotein cholesterol (LDL-C) for major adverse cardiovascular events (MACE) in patients with coronary heart disease (CHD) complicated by type 2 diabetes mellitus (T2DM).Methods:A total of 248 patients with CHD and T2DM admitted to the First Affiliated Hospital of Xinjiang Medical University from July 2022 to January 2024 were retrospectively enrolled. All patients were followed up for 2 years and divided into MACE group (43 cases) and non-MACE group (205 cases) according to the occurrence of MACE. Indicators such as TyG index and LDL-C were compared between the two groups, and their correlations with MACE were analyzed. Multivariate logistic regression was used to screen the risk factors for MACE in patients with CHD and T2DM. Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of TyG index, LDL-C, and their combination for MACE in these patients.Results:Compared with the non-MACE group, the MACE group had significantly higher LDL-C [2.63(2.23, 2.95)mmol/L vs 1.99(1.60, 2.66)mmol/L, P<0.001] and TyG index [9.30(8.80, 9.87) vs 8.60(8.09, 9.15), P<0.001]. Multivariate logistic regression showed that TyG index was an independent risk factor for MACE in patients with CHD and T2DM ( OR=10.49, P<0.001). ROC curve results indicated that the area under the curve (AUC) of TyG index and LDL-C for predicting MACE were 0.731 and 0.686, respectively. The combined AUC of the two indicators for predicting MACE was 0.769(95% CI: 0.698-0.840), showing better predictive performance. Conclusions:TyG index combined with LDL-C has high predictive value for the risk of MACE in patients with CHD complicated by T2DM.