The incidence of brain metastasis from the ovarian cancer is increasing because of the increased survival rate of the ovarian cancer patients and new development of the diagnostic imaging study. The traditional treatment of the brain metastasis is whole brain radiation therapy and recent trend of the treatment is multidisciplinary treatment (radiation therapy, surgery, radiosurgery, and chemotherapy). Recently we experienced a case with multiple brain metastases from the ovarian cancer which were treated by a multimodality approach including gamma-knife radiosurgery. She was diagnosed as epithelial ovarian cancer, FIGO stage IIIc, and underwent 9 cycles of cisplatin based combination chemotherapy (cyclophospamide, THP, cisplatin) after optimal cytoreductive surgery with Hartmans operation. Complete remission was achieved, but multiple brain metastases were detected 56 months after the initial diagnosis of ovarian cancer. She had no recurrent lesion outside the brain, and underwent surgical resection of the one respectable lesion and then gamma-knife radiosurgery for another unresectable lesion. She remains in a disease-free state without any symptoms for 4 months. We report this case with a brief review of the concerned literatures.
Brain* ; Cisplatin ; Diagnosis ; Diagnostic Imaging ; Drug Therapy, Combination ; Humans ; Incidence ; Neoplasm Metastasis* ; Ovarian Neoplasms* ; Radiosurgery ; Survival Rate

Strumal carcinoid of ovary is an unusual form of monodermal ovarian teratoma with thyroid-like follicles admixed with typical carcinoid tumor pattern. Most of them arise in dermoid cyst or in mature solid teratoma. Recently we experienced a case of strumal carcinoid postoperatively and report this case with a brief review of the concerned literatures.
Carcinoid Tumor* ; Dermoid Cyst ; Female ; Ovarian Neoplasms ; Ovary* ; Teratoma

A case of intermediate differentiated Sertoli-Leydig cell tumor with elevated Alpha-fetoprotein (AFP) levels occurred in a 15-year-old girl. No germ cell component and no heterologous elements were identified. Secretion of AFP by Sertoli-Leydig cell tumor has rarely been mentioned previously, and its mechanism is difficult to explain. We present this case with review of related literatures.
Adolescent ; alpha-Fetoproteins* ; Female ; Germ Cells ; Humans ; Ovary* ; Sertoli-Leydig Cell Tumor*

Angiosarcoma is rare malignant neoplasms, which account for less than 1% of all sarcomas. They have a wide distribution in various body organs and tissues: approximately a third of cases occur in the skin and a quarter in soft tissues. Angiosarcoma rarely involves the female reproductive system. We present a case of a 37-yaer-old woman who had primary angiosarcoma of the left breast; With metastases to the spleen and ovary.
Breast ; Female ; Hemangiosarcoma* ; Humans ; Neoplasm Metastasis ; Ovary* ; Sarcoma ; Skin ; Spleen

Embryonal rhabdomyosarcoma, called sarcoma botryoides, is the most common malignant tumor arising from in the infant vagina. This tumor is diagnosed before the age of 5 and highly malignant. We experienced a case of embryonal rhabdomyosarcoma arising from vaginal wall in 5-year-old girl. Authors presented this case with a brief review of literature.
Child* ; Child, Preschool* ; Female ; Humans ; Infant ; Rhabdomyosarcoma, Embryonal* ; Sarcoma ; Vagina

Genital tract tuberculosis is uncommon disease, and usually developed secondary to a primary focus elsewhere in the body. The incidence of cervical involvement in genital tract tuberculosis is extremely low. The disease remains prevalent in developing countries and with changing patterns its incidence in developed countries appears to be increasing. The gross appearance of cervical tuberculosis is most commonly confused with cervical carcinoma. We report two cases of tuberculosis of cervix of uterus with brief review of literature.
Cervix Uteri ; Developed Countries ; Developing Countries ; Female ; Incidence ; Tuberculosis ; Uterine Cervicitis* ; Uterus

The incidence of uterine myoma with cystic degeneration is 4% and symptomatic uterine myoma requires surgical management. We experienced a case of intraligamentary leiomyoma with huge cystic degeneration with its total weight 2526gm in 48 years old woman and brief review of the case and its literatures are presented.
Female ; Humans ; Incidence ; Leiomyoma* ; Middle Aged

OBJECTIVE: Our study was performed to assess prevalence of HPV infections in general female population of Korea and efficacy of HPV DNA test as an adjunctive screening of cervical cancer. MATERIALS AND METHODS: From January 2000 to December 2000, a total 689 patients who had undergone Pap smear and HPV DNA test using Hybrid Capture System-II were included in this study. High risk types of HPV included 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68. We performed colposcopic biopsy on 203 patients. RESULTS: High-risk oncogenic HPV infections were found in the 19.4% of the investigated patients. The sensitivity and negative predictive value of Pap smear alone in identifying the lesions more severe than CIN 2 was 72.2% and 83.2%, respectively. The combination of Pap smear and high risk HPV testing increased to 96.3% and 95.3%, respectively. CONCLUSIONS: The prevalence of HPV infection in general population was 19.4%. The use of HPV DNA testing significantly improved the sensitivity or negative predictive value of the diagnosis of high grade CIN or cancer. Thus, we suggest HPV DNA testing appears to be a needed adjunct to the Pap smear and a combined screening test offers the possibility of greater detection or longer screening intervals, which will be able to reduce the overall cost of the screening program.
Biopsy ; Diagnosis ; Female ; Human Papillomavirus DNA Tests* ; Humans ; Korea* ; Mass Screening* ; Prevalence* ; Uterine Cervical Neoplasms*

OBJECTIVES: We studied peritoneal fluid and serum LDH levels to identify patients with ovarian carcinoma and differentiate them from patients with benign ovarian tumor or other gynecological tumors. METHODS: From July 1998 to May 1999, peritoneal fluid and serum LDH, serum CA-125 levels were measured in 95 patients: 11 with ovarian carcinoma, 2 with borderline ovarian tumor, 45 with benign ovarian tumor, 2 with endometrial carcinoma, 21 with CIS, 7 with cervical cancer and 7 with uterine myoma. RESULTS: Peritoneal fluid LDH and serum LDH and CA-125 levels in ovarian cancer patients were significantly higher than those in patients with benign ovarian tumor and other gynecological tumors(p<0.05). Peritoneal fluid LDH demonstrated higher sensitivity(100%) and greater diagnostic efficiency(86%) than serum LDH(73% and 84%, respectively) or serum CA-125.(82% and 83%, respectively) CONCLUSION: Peritoneal fluid LDH, compared to serum LDH and serum CA-125, presented the greatest diagnostic efficiency in discriminating ovarian cancer from benign ovarian tumor and, therefore, it may be efficient as a biochemical marker in diagnosis of ovarian cancer, even in early stages of the disease.
Ascitic Fluid* ; Biomarkers ; Diagnosis ; Endometrial Neoplasms ; Female ; Humans ; Lactic Acid* ; Leiomyoma ; Ovarian Neoplasms* ; Uterine Cervical Neoplasms

OBJECTIVE: For many years, the Papanicolaou smear has been used to detect pre-malignant and malignant disease of the cervix. Although the use of cytology in screening has reduced morbidity and mortality from invasive cervical cancer, there has been concerned about the low sensitivity of cervical cytology in detection of preclinical disease of the cervix. So cervicography is introduced. In order to find out the efficacy of cytology and cervicography in early diagnosis of cervical cancer, this study included 1028 patients who visited the Department of Obstetrics and Gynecology, Cho-sun University Hospital From December 1, 1995 to March 31, 1998. And we choosed 321 samples who underwent biopsies. METHODS: Women simultaneously underwent an exo and endo-cervical smear, and then two cervicography was obtained with applying 5% acetic acid. Because all of the subjects choosed in statistical analysis were examined by colposcopy or postoperative biopsies, the presence or abscence of disease was determined by the histologic findings. RESULTS: 1. The sensitivity and specificity of cytology was 55.4% and 86.6%. 2. The sensitivity and specificity of cervicography was 71.3% and 59.7%. 3. When cervicography and Papanicolaou smear were used conjointly, the sensitivity and specificity was 90.1% and 58.8%. 4. However the specificity of the combined test was lower than cytology alone, the sensitivity of the combined test was significantly higher. CONCLUSION: The double combined tests of Papanicolaou smear and Cervicography were very useful in the early diagnosis of cervical neoplasia.
Acetic Acid ; Biopsy ; Cervix Uteri ; Colposcopy ; Early Diagnosis ; Female ; Gynecology ; Humans ; Mass Screening* ; Mortality ; Obstetrics ; Papanicolaou Test ; Sensitivity and Specificity ; Uterine Cervical Neoplasms*