Purpose: Line Operations Safety Audit (LOSA) has reduced errors by detecting and managing threats and errors of flight deck crew in the cockpit during normal flight operations. Airlines can understand the countermeasures and competencies of the crew and the success of error management. This paper introduces the advantages of LOSA and how LOSA data collection can be enhanced for the safety of flight operations. Methods: It analyzed the components of data collection tool in the International Civil Aviation Organization Doc 9803, LOSA manual to find out the deficiencies for enhancement. Results: Five suggestions are proposed in this study, codes for positive activities and the development of a form, the development of proactive strategies that predict threats in advance and manage the threats and management of errors, to describe the coding and narrative for successful briefings that manage threats and errors and codes for positive culture are required for successful LOSA data collection flight operations. Conclusion Safety Management System, Threat and Error Management, LOSA, and other conventional safety tools manage safety based on risk or failure, so if we change the paradigm, we can train more safety-resilient pilots. The tragic outcomes such as accidents or incidents have the problem of low occurrence probability, but if we supplement and utilize LOSA data of normal flights, we can prevent accidents or nearaccidents in advance.

Purpose: Line Operations Safety Audit (LOSA) has reduced errors by detecting and managing threats and errors of flight deck crew in the cockpit during normal flight operations. Airlines can understand the countermeasures and competencies of the crew and the success of error management. This paper introduces the advantages of LOSA and how LOSA data collection can be enhanced for the safety of flight operations. Methods: It analyzed the components of data collection tool in the International Civil Aviation Organization Doc 9803, LOSA manual to find out the deficiencies for enhancement. Results: Five suggestions are proposed in this study, codes for positive activities and the development of a form, the development of proactive strategies that predict threats in advance and manage the threats and management of errors, to describe the coding and narrative for successful briefings that manage threats and errors and codes for positive culture are required for successful LOSA data collection flight operations. Conclusion Safety Management System, Threat and Error Management, LOSA, and other conventional safety tools manage safety based on risk or failure, so if we change the paradigm, we can train more safety-resilient pilots. The tragic outcomes such as accidents or incidents have the problem of low occurrence probability, but if we supplement and utilize LOSA data of normal flights, we can prevent accidents or nearaccidents in advance.

Purpose: Line Operations Safety Audit (LOSA) has reduced errors by detecting and managing threats and errors of flight deck crew in the cockpit during normal flight operations. Airlines can understand the countermeasures and competencies of the crew and the success of error management. This paper introduces the advantages of LOSA and how LOSA data collection can be enhanced for the safety of flight operations. Methods: It analyzed the components of data collection tool in the International Civil Aviation Organization Doc 9803, LOSA manual to find out the deficiencies for enhancement. Results: Five suggestions are proposed in this study, codes for positive activities and the development of a form, the development of proactive strategies that predict threats in advance and manage the threats and management of errors, to describe the coding and narrative for successful briefings that manage threats and errors and codes for positive culture are required for successful LOSA data collection flight operations. Conclusion Safety Management System, Threat and Error Management, LOSA, and other conventional safety tools manage safety based on risk or failure, so if we change the paradigm, we can train more safety-resilient pilots. The tragic outcomes such as accidents or incidents have the problem of low occurrence probability, but if we supplement and utilize LOSA data of normal flights, we can prevent accidents or nearaccidents in advance.

Purpose: Line Operations Safety Audit (LOSA) has reduced errors by detecting and managing threats and errors of flight deck crew in the cockpit during normal flight operations. Airlines can understand the countermeasures and competencies of the crew and the success of error management. This paper introduces the advantages of LOSA and how LOSA data collection can be enhanced for the safety of flight operations. Methods: It analyzed the components of data collection tool in the International Civil Aviation Organization Doc 9803, LOSA manual to find out the deficiencies for enhancement. Results: Five suggestions are proposed in this study, codes for positive activities and the development of a form, the development of proactive strategies that predict threats in advance and manage the threats and management of errors, to describe the coding and narrative for successful briefings that manage threats and errors and codes for positive culture are required for successful LOSA data collection flight operations. Conclusion Safety Management System, Threat and Error Management, LOSA, and other conventional safety tools manage safety based on risk or failure, so if we change the paradigm, we can train more safety-resilient pilots. The tragic outcomes such as accidents or incidents have the problem of low occurrence probability, but if we supplement and utilize LOSA data of normal flights, we can prevent accidents or nearaccidents in advance.

Purpose: Line Operations Safety Audit (LOSA) has reduced errors by detecting and managing threats and errors of flight deck crew in the cockpit during normal flight operations. Airlines can understand the countermeasures and competencies of the crew and the success of error management. This paper introduces the advantages of LOSA and how LOSA data collection can be enhanced for the safety of flight operations. Methods: It analyzed the components of data collection tool in the International Civil Aviation Organization Doc 9803, LOSA manual to find out the deficiencies for enhancement. Results: Five suggestions are proposed in this study, codes for positive activities and the development of a form, the development of proactive strategies that predict threats in advance and manage the threats and management of errors, to describe the coding and narrative for successful briefings that manage threats and errors and codes for positive culture are required for successful LOSA data collection flight operations. Conclusion Safety Management System, Threat and Error Management, LOSA, and other conventional safety tools manage safety based on risk or failure, so if we change the paradigm, we can train more safety-resilient pilots. The tragic outcomes such as accidents or incidents have the problem of low occurrence probability, but if we supplement and utilize LOSA data of normal flights, we can prevent accidents or nearaccidents in advance.

Although gemcitabine-based regimens are widely used as an effective treatment for pancreatic cancer, acquired resistance to gemcitabine has become an increasingly common problem. Therefore, a novel therapeutic strategy to treat gemcitabine-resistant pancreatic cancer is urgently required. Piceamycin has been reported to exhibit antiproliferative activity against various cancer cells; however, its underlying molecular mechanism for anticancer activity in pancreatic cancer cells remains unexplored. Therefore, the present study evaluated the antiproliferation activity of piceamycin in a gemcitabine-resistant pancreatic cancer cell line and patient-derived pancreatic cancer organoids. Piceamycin effectively inhibited the proliferation and suppressed the expression of alpha-actinin-4, a gene that plays a pivotal role in tumorigenesis and metastasis of various cancers, in gemcitabine-resistant cells. Long-term exposure to piceamycin induced cell cycle arrest at the G0/G1 phase and caused apoptosis. Piceamycin alsoinhibited the invasion and migration of gemcitabine-resistant cells by modulating focal adhesion and epithelial-mesenchymal transition biomarkers. Moreover, the combination of piceamycin and gemcitabine exhibited a synergistic antiproliferative activity in gemcitabine-resistant cells. Piceamycin also effectively inhibited patient-derived pancreatic cancer organoid growth and induced apoptosis in the organoids. Taken together, these findings demonstrate that piceamycin may be an effective agent for overcoming gemcitabine resistance in pancreatic cancer.

Purpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have greatly improved survival in EGFR-mutant (EGFRm) non–small cell lung cancer (NSCLC); however, their effects on the tumor microenvironment (TME) are unknown. We assessed the changes induced by neoadjuvant erlotinib therapy (NE) in the TME of operable EGFRm NSCLC. Materials and Methods: This was a single-arm phase II trial for neoadjuvant/adjuvant erlotinib therapy in patients with stage II/IIIA EGFRm NSCLC (EGFR exon 19 deletion or L858R mutations). Patients received up to 2 cycles of NE (150 mg/day) for 4 weeks, followed by surgery and adjuvant erlotinib or vinorelbine plus cisplatin therapy depending on observed NE response. TME changes were assessed based on gene expression analysis and mutation profiling. Results: A total of 26 patients were enrolled; the median age was 61, 69% were female, 88% were stage IIIA, and 62% had L858R mutation. Among 25 patients who received NE, the objective response rate was 72% (95% confidence interval [CI], 52.4 to 85.7). The median disease-free and overall survival (OS) were 17.9 (95% CI, 10.5 to 25.4) and 84.7 months (95% CI, 49.7 to 119.8), respectively. Gene set enrichment analysis in resected tissues revealed upregulation of interleukin, complement, cytokine, transforming growth factor β, and hedgehog pathways. Patients with upregulated pathogen defense, interleukins, and T-cell function pathways at baseline exhibited partial response to NE and longer OS. Patients with upregulated cell cycle pathways at baseline exhibited stable/progressive disease after NE and shorter OS. Conclusion NE modulated the TME in EGFRm NSCLC. Upregulation of immune-related pathways was associated with better outcomes.

Previously, we reported the concept of a cloud-based telemedicine platform for patients with intracerebral hemorrhage (ICH) at local emergency rooms in rural and medically underserved areas in Gangwon state by combining artificial intelligence and remote consultation with a neurosurgeon. Developing a telemedicine ICH treatment protocol exclusively for doctors with less ICH expertise working in emergency rooms should be part of establishing this system. Difficulties arise in providing appropriate early treatment for ICH in rural and underserved areas before the patient is transferred to a nearby hub hospital with stroke specialists. This has been an unmet medical need for decade. The available reporting ICH guidelines are realistically possible in university hospitals with a well-equipped infrastructure. However, it is very difficult for doctors inexperienced with ICH treatment to appropriately select and deliver ICH treatment based on the guidelines. To address these issues, we developed an ICH telemedicine protocol. Neurosurgeons from four university hospitals in Gangwon state first wrote the guidelines, and professors with extensive ICH expertise across the country revised them. Guidelines and recommendations for ICH management were described as simply as possible to allow more doctors to use them easily. We hope that our effort in developing the telemedicine protocols will ultimately improve the quality of ICH treatment in local emergency rooms in rural and underserved areas in Gangwon state.

Purpose: The purpose of this study is to understand the air traffic control (ATC) threats that cause airline pilots to commit errors during normal operations by identifying the prevalence of ATC threats to reduce ATC communication errors for safe flights. This study deals with ATC communication threats effect on the human performance of pilots through LOSA (line operations safety audit) implemented by Airlines. Methods: This study deals with ATC communication threats effect on the human performance of pilots through LOSA implemented by two domestic Airlines. Results: The prevalence of ATC threats shows that there are 60% of flights with at least one ATC-related threat. The frequent ATC threats have been identified as difficulties in understanding controller accents, changes of the runway, errors by ATC controllers, difficult clearance of altitude change and multiple clearances in one call. The most prevailing ATC threats occurred during the Descend, Approach & Land phase of the flight. Conclusion In order to prevent accidents related with ATC and improve threats and human errors in the actual environment of pilots, it is necessary to identify and analyze the actual threats and errors in the cockpit regarding ATC. It is required to improve the management of ATC threats proactively. According to LOSA result, ATC threats are a frequent threat to pilots, and the most frequent type of ATC for pilots is difficult Accent or language to understand controller. These findings could be trained in the simulators and cockpit in a similar environment and workload as in actual flight for effective countermeasures.

Background: Coronavirus disease 2019 (COVID-19) is known to have a high incidence of loss of smell and taste. However, studies in the early stages of the COVID-19 pandemic have evaluated these symptoms using subjective surveys and simple olfactory tests only. Hence, we compared the olfactory and gustatory characteristics of patient groups with COVID-19 olfactory dysfunction (C19OD) and non-COVID-19 postinfectious olfactory dysfunction (PIOD) using an objective olfactory test and evaluated the significance of olfactory training in both patient groups. Methods: We retrospectively analyzed the medical records of 14 patients with a decreased sense of smell after having positive COVID-19 polymerase chain reaction results, and 56 patients with PIOD with no history of confirmed COVID-19. Participants were evaluated using the Korean version of the Sniffin’ stick (KVSS) II, and chemical gustometry and olfactory training was assessed during their first visit. Olfactory training was then re-evaluated after an average of 8 (± 6) weeks. Results: The average age of participants in the C19OD group was lower than in those in the non-COVID-19 PIOD group. The proportion of men in the C19OD group was higher than in the non-COVID-19 PIOD group. At baseline assessment, the C19OD group had better olfactory and gustatory functions. After olfactory training, the non-COVID-19 PIOD patient group showed a significant increase in all KVSS II Total, T, D, and I scores, but there was a non-significant increase in all scores in the C19OD group. Conclusion The C19OD group had better olfactory and gustatory function than the nonCOVID-19 PIOD group at the initial assessment. After olfactory training, there was an increase in olfactory function test scores in both groups. Olfactory training may be helpful in C19OD, as in non-COVID-19 PIOD.