1.Differentiation of uterine fibroids and sarcomas by MRI and serum LDH levels: a multicenter study of the KAMOGAWA study
Yukio YAMANISHI ; Yasushi KOTANI ; Aki KIDO ; Tomoyuki OTANI ; Yuki HIMOTO ; Yasuhisa KURATA ; Kosuke MURAKAMI ; Hisamitsu TAKAYA ; Masahiro SUMITOMO ; Ikuko EMOTO ; Motonori MATSUBARA ; Naoki HORIKAWA ; Kana AKAGI ; Kentaro ISHIDA ; Aya TAKAORI ; Azusa SAKURAI ; Kaoru ABIKO ; Koji YAMANOI ; Masaki MANDAI ; Noriomi MATSUMURA
Journal of Gynecologic Oncology 2025;36(4):e58-
Objective:
In the differential diagnosis between uterine fibroids and uterine sarcomas, realworld magnetic resonance imaging (MRI) diagnostic information is scarce; furthermore, high diagnostic sensitivity is important in clinical practice. We previously developed a diagnostic algorithm to detect uterine sarcoma with high sensitivity using simple MRI images and serum lactate dehydrogenase (LDH) levels. In this multicenter study, we investigated the preoperative diagnosis of sarcoma in the real world and further validated the usefulness of our diagnostic algorithm.
Methods:
Of 154 uterine sarcomas and 154 uterine fibroids treated at 15 centers between January 2006 and December 2020, 139 sarcomas (16 smooth muscle tumors of uncertain malignant potential) and 141 fibroids with diffusion-weighted imaging information were included in the analysis. The diagnostic algorithm was validated by 3 radiologists who were blinded to the clinical information and pathologic diagnoses and who read the MRIs.
Results:
The sensitivity/specificity of preoperative diagnosis was 77.7%/92.9% for the preoperative report; 92.1%/72.3% for algorithm A; and 82.0%/85.8% for algorithm B (McNemar’s test p<0.05). Comparison of overall survival rates among 3 groups (Group 1: negative A, Group 2: positive A and negative B; Group 3: positive B) using algorithms A and B showed p=0.012. On multivariate analysis, stage, and serum LDH level were independent prognostic factors.
Conclusion
MRI is useful for preoperative diagnosis of uterine sarcoma, and the sarcoma diagnostic algorithm presented in this study is an option for diagnosing sarcoma with greater sensitivity. This information should be shared with patients.
2.Communication Education for Medical Students Based on Motivational Interview and Nonverbal Communication
Shuntaro AOKI ; Yoshitake TAKEBAYASHI ; Yayoi SHIKAMA ; Kiyotaka YASUI ; Koji OTANI
Medical Education 2021;52(4):295-304
Introduction: This paper reports the results of a practical communication education program for medical students that incorporates motivational interviewing and nonverbal communication. Methods: Changes in confidence in communication before and after the class were measured with the NRS scale and a corresponding t-test, and qualitative analysis of the class feedback was conducted by text mining using KH coders and content analysis. Results: The results showed that the students’ confidence in communication increased after the class. The most frequently mentioned topics in the feedback were communication, ability, class, learning, self, questions, conversation, speaking, partner, and listening. Conclusions: This is the first validation of the effectiveness of motivational interviewing and nonverbal communication in improving the communication confidence of Japanese medical students.
3.Progress in Recognizing and Comprehending of Medical Terms Among Medical Students
Akiko SUGAWARA ; Yoko MOROI ; Gen KOBAYASHI ; Koji OTANI ; Kazunobu ISHIKAWA
Medical Education 2019;50(6):563-567
Introduction: To implement effective medical education, it is important to clarify the process of recognizing and comprehending medical terms. Methods: We conducted a questionnaire survey of 492 first- to fifth-year medical students to evaluate the recognition and comprehension rates of 57 medical terms in each grade. The terms were classified using the hierarchical cluster analysis based on the recognition and comprehension rates. Results: The response rate was 91.1% (n=448). The 57 terms were classified into the following five clusters: #1, 30 terms that the students recognized and comprehended from Y1; #2, 18 terms that the students recognized from Y1 and comprehended as the grade increased; #3, six terms that the students recognized and comprehended as the grade increased; #4, two terms that the students recognized from Y1 but had not comprehended even in upper grades; #5, one term that the students recognized as the grade increased but had not comprehended even in Y5. Discussion: Teachers may need to devise educational strategies while considering different patterns of students’ recognition and comprehension of medical terms.
4.Surgical Outcomes of Cervical Myelopathy in Patients with Athetoid Cerebral Palsy: A 5-Year Follow-Up.
Kazuyuki WATANABE ; Koji OTANI ; Takuya NIKAIDO ; Kinshi KATO ; Hiroshi KOBAYASHI ; Shoji YABUKI ; Shin Ichi KIKUCHI ; Shin Ichi KONNO
Asian Spine Journal 2017;11(6):928-934
STUDY DESIGN: Observational cohort study. PURPOSE: To assess the surgical outcomes of posterior decompression and fusion for cervical myelopathy in patients with athetoid cerebral palsy. OVERVIEW OF LITERATURE: Patients with athetoid cerebral palsy demonstrate involuntary movements and develop severe cervical spondylosis with kyphosis. In these patients, surgery is often performed at an early age because of myelopathy. A few studies have reported about the long-term outcomes of surgical treatment; however, they contain insufficient information. METHODS: From 2003 to 2008, 13 patients with cervical myelopathy due to athetoid cerebral palsy underwent posterior fusion surgery and were included in this study. The Japanese Orthopaedic Association (JOA) score, neck disability index (NDI), C2–7 angle on radiography, and need for additional surgical treatment were examined at 1 and 5 years postoperatively. RESULTS: The mean C2–7 angle was −10.5°±21.1° preoperatively and was corrected to −2.9°±13.5° immediately postoperatively. This improvement was maintained for 5 years. The JOA score was 9.5±2.5 preoperatively and 12.2±1.7 at the 5-year follow-up. NDI was 17±6.9 preoperatively and 16±7.5 at the 5-year follow-up. Patient satisfaction with surgery on a 100-point scale was 62.2±22.5 at the 5-year follow-up. Three patients needed additional surgery for loosening of screws. These results demonstrate good surgical outcomes for posterior fusion at 5 years. CONCLUSIONS: Posterior decompression and fusion should be considered a viable option for cervical myelopathy in patients with athetoid cerebral palsy.
Asian Continental Ancestry Group
;
Cerebral Palsy*
;
Cohort Studies
;
Decompression
;
Dyskinesias
;
Follow-Up Studies*
;
Humans
;
Kyphosis
;
Neck
;
Patient Satisfaction
;
Radiography
;
Spinal Cord Diseases*
;
Spine
;
Spondylosis
5.Evaluation of Risk Priority of the Dispensing Process by Using a Risk Management System in Community Pharmacies
Kazuyuki Yoshida ; Koji Hayashi ; Asaka Kanda ; Yuko Doi ; Kiichi Otani ; Ken Iseki
Japanese Journal of Drug Informatics 2012;14(1):21-25
Objective: It is important to prevent dispensing errors for the safety of patients. For this purpose, it is necessary to improve the dispensing process on the basis of risk priority. Quantitative evaluation of risk in each operation makes it possible to compare the risk relatively. In this study, we analyzed data reported in the Pharmacy Risk Error Management System (PREM-S) to evaluate the risk priority in the medicine preparation step of the dispensing process.
Methods: Data of 1,202 cases concerning medicine preparation step were extracted from in 2,458 cases reported into PREM-S between May 2010 and April 2011. We classified the medicine preparation step into 31 categories based on the operation. We analyzed the levels in each category as adverse effects on patient’s health by the errors and also the relationship between adverse effect and detection time. The level represents the degree of adverse effect for the patient.
Results: Information on levels of the 31 categories was obtained from the analysis. Eight categories included reports of effects on the health of patients. Three categories such as calculation of powder medicine included level 4 cases. Detection time was significantly different between level 1 and levels 2 to 4, but there was no significant difference between levels 2 to 4.
Conclusion: The results suggest that analysis of data reported in PREM-S enables evaluation of the risk priority systematically and efficiently. Evaluation of the risk priority will contribute to prevention of dispensing errors and health effects derived from them.


Result Analysis
Print
Save
E-mail