At age 44, the live birth rate per in vitro fertilization (IVF) embryo transfer is low, and natural pregnancy is very rare. Here, we report a case of an older infertile patient who gave up on pregnancy after repeated unsuccessful IVF attempts, developed diarrhea, and was administered shinbuto and ninjinto, which are similar to the prescription of bukuryoshigyakuto. She subsequently conceived naturally, resulting in a live birth. The patient was 44 years old and nulligravid. She had undergone IVF eight times, but had never achieved pregnancy. After giving up on pregnancy, she developed diarrhea and other symptoms. With the administration of shinbuto extract granules (7.5 g/day) and ninjinto extract granules (7.5 g/day), her diarrhea completely resolved, and mental symptoms such as irritability and depression also improved. Her menstrual cycle normalized to a 28-day cycle, and natural pregnancy was achieved. The pregnancy progressed smoothly, and at 38 weeks of pregnancy, a cesarean section was performed due to the indication of rigidity of the soft birth canal, resulting in a live birth at age 45. These results suggest that shinbuto and ninjinto, which are similar to the prescription of bukuryoshigyakuto, may be effective in treating the severe fatigue and mental stress experienced after abandoning pregnancy attempts.