Background: Complete revascularization has demonstrated better outcomes in patients with acute myocardial infarction (AMI) and multivessel disease. However, in the case of left main (LM) culprit lesion AMI with multivessel disease, there is limited evidence to suggest that complete revascularization is better. Methods: We reviewed 16,831 patients in the Korea Acute Myocardial Infarction Registry who were treated from July 2016 to June 2020, and 399 patients were enrolled with LM culprit lesion AMI treated with percutaneous coronary intervention. We categorized the patients as those treated with complete revascularization (n=295) or incomplete revascularization (n=104). The study endpoint was major adverse cardiac and cerebrovascular events (MACCE), a composite of all-cause death, myocardial infarction, ischemia-driven revascularization, stent thrombosis, and stroke. We performed propensity score matching (PSM) and analyzed the incidence of MACCE at 1 year. Results: After PSM, the two groups were well balanced. There was no significant difference between the two groups in MACCE at 1 year (12.1% vs. 15.2%; hazard ratio, 1.28; 95% confidence interval, 0.60–2.74; p=0.524) after PSM. The components of MACCE and major bleeding were also not significantly different. Conclusion There was no significant difference in clinical outcomes between the groups treated with complete or incomplete revascularization for LM culprit lesion AMI with multivessel disease.

Background: Complete revascularization has demonstrated better outcomes in patients with acute myocardial infarction (AMI) and multivessel disease. However, in the case of left main (LM) culprit lesion AMI with multivessel disease, there is limited evidence to suggest that complete revascularization is better. Methods: We reviewed 16,831 patients in the Korea Acute Myocardial Infarction Registry who were treated from July 2016 to June 2020, and 399 patients were enrolled with LM culprit lesion AMI treated with percutaneous coronary intervention. We categorized the patients as those treated with complete revascularization (n=295) or incomplete revascularization (n=104). The study endpoint was major adverse cardiac and cerebrovascular events (MACCE), a composite of all-cause death, myocardial infarction, ischemia-driven revascularization, stent thrombosis, and stroke. We performed propensity score matching (PSM) and analyzed the incidence of MACCE at 1 year. Results: After PSM, the two groups were well balanced. There was no significant difference between the two groups in MACCE at 1 year (12.1% vs. 15.2%; hazard ratio, 1.28; 95% confidence interval, 0.60–2.74; p=0.524) after PSM. The components of MACCE and major bleeding were also not significantly different. Conclusion There was no significant difference in clinical outcomes between the groups treated with complete or incomplete revascularization for LM culprit lesion AMI with multivessel disease.

Background: Complete revascularization has demonstrated better outcomes in patients with acute myocardial infarction (AMI) and multivessel disease. However, in the case of left main (LM) culprit lesion AMI with multivessel disease, there is limited evidence to suggest that complete revascularization is better. Methods: We reviewed 16,831 patients in the Korea Acute Myocardial Infarction Registry who were treated from July 2016 to June 2020, and 399 patients were enrolled with LM culprit lesion AMI treated with percutaneous coronary intervention. We categorized the patients as those treated with complete revascularization (n=295) or incomplete revascularization (n=104). The study endpoint was major adverse cardiac and cerebrovascular events (MACCE), a composite of all-cause death, myocardial infarction, ischemia-driven revascularization, stent thrombosis, and stroke. We performed propensity score matching (PSM) and analyzed the incidence of MACCE at 1 year. Results: After PSM, the two groups were well balanced. There was no significant difference between the two groups in MACCE at 1 year (12.1% vs. 15.2%; hazard ratio, 1.28; 95% confidence interval, 0.60–2.74; p=0.524) after PSM. The components of MACCE and major bleeding were also not significantly different. Conclusion There was no significant difference in clinical outcomes between the groups treated with complete or incomplete revascularization for LM culprit lesion AMI with multivessel disease.

Background: Complete revascularization has demonstrated better outcomes in patients with acute myocardial infarction (AMI) and multivessel disease. However, in the case of left main (LM) culprit lesion AMI with multivessel disease, there is limited evidence to suggest that complete revascularization is better. Methods: We reviewed 16,831 patients in the Korea Acute Myocardial Infarction Registry who were treated from July 2016 to June 2020, and 399 patients were enrolled with LM culprit lesion AMI treated with percutaneous coronary intervention. We categorized the patients as those treated with complete revascularization (n=295) or incomplete revascularization (n=104). The study endpoint was major adverse cardiac and cerebrovascular events (MACCE), a composite of all-cause death, myocardial infarction, ischemia-driven revascularization, stent thrombosis, and stroke. We performed propensity score matching (PSM) and analyzed the incidence of MACCE at 1 year. Results: After PSM, the two groups were well balanced. There was no significant difference between the two groups in MACCE at 1 year (12.1% vs. 15.2%; hazard ratio, 1.28; 95% confidence interval, 0.60–2.74; p=0.524) after PSM. The components of MACCE and major bleeding were also not significantly different. Conclusion There was no significant difference in clinical outcomes between the groups treated with complete or incomplete revascularization for LM culprit lesion AMI with multivessel disease.

Purpose: The purpose of this study was to evaluate the fracture strength of zirconia crowns of varying margin thicknesses. Materials and Methods: A model of the maxillary right first molar (Nissin, Kyoto, Japan) was prepared to create an abutment, which was fabricated into a metal die via a 3D metal printer. CAD software (exocad GmbH, Darmstadt, Germany) was used to design the crowns. A total of eight groups were generated: initially separated by margin thickness (0.1 mm and 0.8 mm), and then further divided by horizontal margin widths of 0.1 mm, 0.2 mm, 0.3 mm, and 0.4 mm. Zirconia crowns were designed for each group’s working models (N=10). Crown fracture strength was assessed using a universal testing machine (Shimadzu, Kyoto, Japan), applying a compressive load until fracture and recording the maximum load. A scanning electron microscope was employed to observe fracture patterns. Fracture strength results were analyzed using one-way ANOVA, with the Tukey HSD test applied for post-hoc analysis (α=0.05). Results: Zirconia crown fracture strength significantly improved with increased horizontal margin width (P<0.001). However, margin thickness had no statistically significant effect on fracture strength (P=0.513). Conclusion Optimizing the horizontal margin width of zirconia crowns enhances their durability and performance.

Purpose: The purpose of this study was to evaluate the fracture strength of zirconia crowns of varying margin thicknesses. Materials and Methods: A model of the maxillary right first molar (Nissin, Kyoto, Japan) was prepared to create an abutment, which was fabricated into a metal die via a 3D metal printer. CAD software (exocad GmbH, Darmstadt, Germany) was used to design the crowns. A total of eight groups were generated: initially separated by margin thickness (0.1 mm and 0.8 mm), and then further divided by horizontal margin widths of 0.1 mm, 0.2 mm, 0.3 mm, and 0.4 mm. Zirconia crowns were designed for each group’s working models (N=10). Crown fracture strength was assessed using a universal testing machine (Shimadzu, Kyoto, Japan), applying a compressive load until fracture and recording the maximum load. A scanning electron microscope was employed to observe fracture patterns. Fracture strength results were analyzed using one-way ANOVA, with the Tukey HSD test applied for post-hoc analysis (α=0.05). Results: Zirconia crown fracture strength significantly improved with increased horizontal margin width (P<0.001). However, margin thickness had no statistically significant effect on fracture strength (P=0.513). Conclusion Optimizing the horizontal margin width of zirconia crowns enhances their durability and performance.

Purpose: The purpose of this study was to evaluate the fracture strength of zirconia crowns of varying margin thicknesses. Materials and Methods: A model of the maxillary right first molar (Nissin, Kyoto, Japan) was prepared to create an abutment, which was fabricated into a metal die via a 3D metal printer. CAD software (exocad GmbH, Darmstadt, Germany) was used to design the crowns. A total of eight groups were generated: initially separated by margin thickness (0.1 mm and 0.8 mm), and then further divided by horizontal margin widths of 0.1 mm, 0.2 mm, 0.3 mm, and 0.4 mm. Zirconia crowns were designed for each group’s working models (N=10). Crown fracture strength was assessed using a universal testing machine (Shimadzu, Kyoto, Japan), applying a compressive load until fracture and recording the maximum load. A scanning electron microscope was employed to observe fracture patterns. Fracture strength results were analyzed using one-way ANOVA, with the Tukey HSD test applied for post-hoc analysis (α=0.05). Results: Zirconia crown fracture strength significantly improved with increased horizontal margin width (P<0.001). However, margin thickness had no statistically significant effect on fracture strength (P=0.513). Conclusion Optimizing the horizontal margin width of zirconia crowns enhances their durability and performance.

Purpose: The purpose of this study was to evaluate the fracture strength of zirconia crowns of varying margin thicknesses. Materials and Methods: A model of the maxillary right first molar (Nissin, Kyoto, Japan) was prepared to create an abutment, which was fabricated into a metal die via a 3D metal printer. CAD software (exocad GmbH, Darmstadt, Germany) was used to design the crowns. A total of eight groups were generated: initially separated by margin thickness (0.1 mm and 0.8 mm), and then further divided by horizontal margin widths of 0.1 mm, 0.2 mm, 0.3 mm, and 0.4 mm. Zirconia crowns were designed for each group’s working models (N=10). Crown fracture strength was assessed using a universal testing machine (Shimadzu, Kyoto, Japan), applying a compressive load until fracture and recording the maximum load. A scanning electron microscope was employed to observe fracture patterns. Fracture strength results were analyzed using one-way ANOVA, with the Tukey HSD test applied for post-hoc analysis (α=0.05). Results: Zirconia crown fracture strength significantly improved with increased horizontal margin width (P<0.001). However, margin thickness had no statistically significant effect on fracture strength (P=0.513). Conclusion Optimizing the horizontal margin width of zirconia crowns enhances their durability and performance.

Background: Fractional flow reserve (FFR) based on computed tomography (CT) has been shown to better identify ischemia-causing coronary stenosis. However, this current technology requires high computational power, which inhibits its widespread implementation in clinical practice. This prospective, multicenter study aimed at validating the diagnostic performance of a novel simple CT based fractional flow reserve (CT-FFR) calculation method in patients with coronary artery disease. Methods: Patients who underwent coronary CT angiography (CCTA) within 90 days and invasive coronary angiography (ICA) were prospectively enrolled. A hemodynamically significant lesion was defined as an FFR ≤ 0.80, and the area under the receiver operating characteristic curve (AUC) was the primary measure. After the planned analysis for the initial algorithm A, we performed another set of exploratory analyses for an improved algorithm B. Results: Of 184 patients who agreed to participate in the study, 151 were finally analyzed.Hemodynamically significant lesions were observed in 79 patients (52.3%). The AUC was 0.71 (95% confidence interval [CI], 0.63–0.80) for CCTA, 0.65 (95% CI, 0.56–0.74) for CT-FFR algorithm A (P = 0.866), and 0.78 (95% CI, 0.70–0.86) for algorithm B (P = 0.112). Diagnostic accuracy was 0.63 (0.55–0.71) for CCTA alone, 0.66 (0.58–0.74) for algorithm A, and 0.76 (0.68–0.82) for algorithm B. Conclusion This study suggests the feasibility of automated CT-FFR, which can be performed on-site within several hours. However, the diagnostic performance of the current algorithm does not meet the a priori criteria for superiority. Future research is required to improve the accuracy.

Background and Objectives: Endovascular therapy (EVT) first strategy has been widely adopted for the treatment of chronic limb threatening ischemia (CLTI) patients in realworld practice. This study aimed to investigate long-term outcomes of CLTI patients who underwent EVT and identify prognostic factors. Methods: From the retrospective cohorts of a Korean multicenter endovascular therapy registry, 1,036 patients with CLTI (792 men, 68.8 ± 9.5 years) were included. The primary endpoint was amputation-free survival (AFS) defined as the absence of major amputation or death. Secondary endpoints were major adverse limb events (MALE; a composite of major amputation, minor amputation, and reintervention). Results: Five-year AFS and freedom from MALE were 69.8% and 61%, respectively. After multivariate analysis, age (hazard ratio [HR], 1.476; p<0.001), end-stage renal disease (ESRD; HR, 2.340; p<0.001), Rutherford category (RC) 6 (HR, 1.456; p=0.036), and suboptimal EVT (HR, 1.798; p=0.005) were identified as predictors of major amputation or death, whereas smoking (HR, 0.594; p=0.007) was protective. Low body mass index (HR, 1.505; p=0.046), ESRD (HR, 1.648; p=0.001), femoropopliteal lesion (HR, 1.877; p=0.004), RC-6 (HR, 1.471;p=0.008), and suboptimal EVT (HR, 1.847; p=0.001) were predictors of MALE. The highest hazard rates were observed during the first 6 months for both major amputation or death and MALE. After that, the hazard rate decreased and rose again after 3–4 years. Conclusions In CLTI patients, long-term outcomes of EVT were acceptable. ESRD, RC-6, and suboptimal EVT were common predictors for poor clinical outcomes.