Background: Chronic eosinophilic leukemia (CEL) is a rare, slowly progressive hematologic malignancy characterized by clonal proliferation of eosinophils in the bone marrow due to underlying genetic mutations. Persistent eosinophilia (>1.5 x 10⁹/L) for 1–6 months is a key diagnostic criterion. The presence of the FIP1L1::PDGFRA fusion gene and increased blast or abnormal cells in the bone marrow further supports the diagnosis. Case presentation: A 63-year-old male presented with symptoms of dry skin, pruritus, skin rash, enlargement of cervical, axillary, and inguinal lymph nodes, headache, and edema. According to the medical history, the disease began 4 years earlier with pruritus in the lower legs and progressed over the past 2 years with worsening skin rash. Complete blood count revealed eosinophilia of 48.6%. Based on leukogram, myelogram, skin histopathology, and cytogenetic analysis performed in China, a diagnosis of chronic eosinophilic leukemia was established. The patient responded well to treatment with imatinib and hydroxycarbamide. Conclusion Clinical manifestations of chronic eosinophilic leukemia are often nonspecific and may be misdiagnosed as dermatological conditions. Therefore, cytogenetic analysis (including FISH), leukogram, myelogram, and skin histopathological examination play a crucial role in accurate diagnosis.

Background: Senear-Usher Syndrome, also known as pemphigus erythematosus, is a rare autoimmune blistering skin disease characterized by overlapping clinical, histopathological, and immunological features of both lupus erythematosus and pemphigus foliaceus. Case Presentation: We report the case of a 46-year-old male diagnosed with Senear-Usher Syndrome, who presented to the outpatient clinic of the National Dermatology Center of Mongolia and received inpatient treatment. Diagnosis: The patient exhibited diffuse, thick, pale gray scales and yellowish crusts on the scalp. Multiple brown hyperpigmented macules of various shapes and sizes, vivid erythema, and a few erosions were observed on the nose, cheeks, trunk, and upper and lower extremities. A few pea-sized vesicles containing clear fluid were scattered on the back. Nikolsky's sign was weakly positive, and Besnier-Meshchersky's sign was positive. Histopathology: Histopathological analysis of skin biopsies revealed hyperkeratosis, parakeratosis, and acanthosis in the epidermis. Subcorneal cleft formation with neutrophils within the cleft was noted, along with perivascular infiltration of neutrophils and lymphohistiocytes in the superficial dermis. Treatment: The patient received treatment with hydroxychloroquine, systemic and topical corticosteroids, and symptomatic therapy. Outcome: Following treatment, the patient's general condition improved significantly. The erosions re-epithelialized, and the vesicles resolved, leaving behind brown hyperpigmented macules. The patient is currently under regular follow-up by a dermatologist and a family physician. Conclusion Senear-Usher Syndrome is a rare disease with a high potential for misdiagnosis. Therefore, an accurate diagnosis relies on a comprehensive evaluation of clinical features, histopathological examination, and direct and indirect immunofluorescence studies.

Background: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease characterized by linear deposition of immunoglobulin A along the subepidermal basement membrane zone. Although it can occur in both children and adults, the disease in pediatric patients often requires careful consideration due to challenges in differential diagnosis and variability in treatment response. Dapsone is considered the first-line treatment; however, in some cases it may be unavailable, contraindicated, or associated with adverse effects, necessitating alternative therapeutic options. Case Presentation In this case report, we present the clinical features, diagnostic findings, treatment course, and outcomes of a 9-year-old girl diagnosed with LABD. The combination of colchicine and systemic corticosteroids resulted in marked clinical improvement, suggesting that this regimen may be a potential alternative treatment for LABD.

Prevalence and incidence of allergic rhinitis have been increasing in the last years in the Asia Pacific countries and for this reason, research on aeroallergen and aeropollinology has also been increasing. The aim of this study was determined morphologic characteristics of Bromus inermis grass pollen. The pollen morphologic characteristics of the Bromus inermis were determined by optic microscopy (Aristoplan, Leitz, Germany). Allergenic protein components of Bromus inermis pollen were purified by the methods of Hames and Richmond. Dry pollen of Bromus inermis has oval shape and concaved on 3 sides. Average length and width of dry pollen of Bromus inermis was 41,5±2,3 µm and 32,3±4,1 µm respectively. These results are consistent with that Gramineae and Poaceae subfamily pollens have oval shapes with length from 22 to 80 µm.

Background: The prevalence and incidence of allergic rhinitis is increasing in the last years in the Asia Pacific countries and for this reason, the number of research in aeroallergen and aeropollinology increasing. It depends on changes of geography, weather and plants, pollination period of time and air pollution.Goal: The aim of this study was determined allergenic characterization of proteins detected from Bromus inermis pollen.Mаterials and Methods: To define morphologic characteristics of Bromus inermis grass pollen and allergenic protein amounts’ of pollen and protein components.- The pollen morphologic characteristics of the Bromus inermis were defined and measured by optic microscopy (Aristoplan, Leitz, Germany).- The allergenic protein components of the Bromus inermis pollen were purified by the method of Hames, Richmond- Protein contents were measured by the Bradford method- The protein components of Bromus inermis pollen were determined by the SDS-PAGEResults and discussion:The diameter of the B.inermis dry pollen were mean length 41, 5±2, 3 μm and mean wide 32, 3±4, 1 μm. B.inermis dry pollen has oval and sphere shape and concaved on 3 sides with diameter 32.3-41.5 μm and was similar results one of subfamily of the Gramineae, Poaceae pollen size were defined 22-80 μm in diameter and with oval and sphere shapes. We were defined 1.5±0.02 mg protein amounts in the 5mg/ml extracts of the purified of the Bromus inermis pollen. Researcher [3] determined 1, 45 mg/ml protein on Elymus chinensis, 1, 96 mg/ml protein on Artimesia sieversiana, 3, 29 mg/ ml protein on Chenopodium album allergens. These study results are similar with our study result on Bradford method. We were defined 7 bands with 12, 26, 32, 55, 66, 84, 97 kDa molecular weight protein components. SDS-PAGE were deteсted relatively bright bands of 12, 32, 55, 66 kDa molecular weight protein components of Bromus inermis pollen proteins. Researcher Kaiser M et al were defined 16, 30, 40, 47, 50, 57, 60, 67, 70, 90, 95 and 110 kDa molecular weight bands in Lolium perenne pollen allergens. These study results are similar with our study result on SDS-PAGE. Conclusions:- The pollen of Bromus inermis was oval and sphere shapes with 32.3-41.5 μm in diameter.- We were defined 1.5±0.02 mg protein amounts in the 1mg/ml of the Bromus inermis pollen.- The 7 bands with 12, 26, 32, 55, 66, 84, 97 kDa molecular weight protein components of Bromus inermis pollen. SDS-PAGE were deteсted relatively bright bands of 12, 32, 55, 66 kDa molecular weight protein components.

In this published case of a male patient B., 53, has some epidemiological specifics. There is transient ischemic attack (TIA) syndrome, particularly while with clear mind there is sudden temporary paralysis of left leg and arm and loss of ability to speak. Temporary refers here to a period of 2-3 minutes after which everything gets back to normal. The incidence occurred again in two days during the medical treatment.MRA test concluded on the presence of obvious stenosis at the beginning part of both sides of a.cerebri media. The mentioned blood vessel pictures were undefined. Hence selected catheter angiography has been done with a purpose to establish the presence of a full occlusion or clogging stenosis in a.cerebri media and to clarify which specific vessels are being mobilized for the collateral supply. This test established that the a.cerebri media had full occlusion on both sides.A duplex sonography conducted in order to clarify characteristics of the clogging (blocking) process concluded the presence of gradual thickening of and blocking in intima (inner wall) of a. carotis interna. Based on these tests we considered that despite the atherosclerosis symptoms (Ischemia in ECG, 20 years of smoking,being male and aged 53, etc), this case had conditions of gradual (slow progressing) arteriopathy. Thus because of the presence in this case simultaneous arteriopathy process (gradually progressing and causing the blocking) in addition to atherosclerosis syndromes we consider it as a Moya-Moya syndrome. The disease of Moya-Moya is mostly found in children and youth and is a unique arteriopathy considered unrelated with atherosclerosis.

Background. Prevalence of essential arterial hypertension is 60-80% among cardiovascular diseases and WHO reported that prevalence of essential arterial hypertension was 90-95% of arterial hypertension and 80% of hospitalized arterial hypertension patients. One of risk factors of essential arterial hypertension is (lack) deficiency of physical activity. Therefore we studied a benefit of exercise in essential arterial hypertension therapy. Methods. We examined blood lipid level and some of cardiovascular indicators of essential arterial hypertension patients such as arterial pressure, heart rate before and after treatment of exercise. Results. Prevalence of essential arterial hypertension was higher in the patients with obesity and overweight. Right high and low blood pressures were decreased from 154 to 141 and from 93 to 85, respectively. The other hand left high and low blood pressures were decreased from 154 to 138 and from 94 to 86, respectively. Heart rate was decreased from 76 to 71.9. Conclusions. Arterial pressure, heart rate and lipid level of the patients with essential arterial hypertension were significantly decreased after treated by exercise.