From the perspective of transfusion medicine and based on the vision and framework of patient blood management, this article combines the advances in basic science, blood transfusion, laboratory, and clinical medicine. It aims to systematically review the key elements and characteristics of patient fibrinogen management by maintaining and optimizing patients' hemostatic function while reducing blood transfusions. This review enriches the connotation of transfusion medicine, especially patient blood management, and provides valuable insights for clinical practice.

Objective To analyze the clinical characteristics of patients with Streptococcus anginosus group(SAG)infected brain abscess and provide a reference basis for the clinical diagnosis and treatment of this disease.Methods The clinical information of 59 patients with brain abscess with SAG in Guangdong Sanjiu Brain Hospital from January 2016 to October 2023 was collected for retrospective statistical analysis.Results Among the 59 patients with brain abscess,there were 52(88.14%)male and 7(11.86%)female.Among 59 cases of SAG,there were 32(54.24%)in the Str.intermedius group,21(35.59%)in the Str.constellatus group and 6(10.17%)in the Str.anginosus group.The age of Str.intermedius group was less than that of Streptococcus constellatus group(36.75±20.06 years vs 50.43±16.17 years),and the difference was statistically significant(t=2.614,P<0.05).The common clinical symptom was headache,while the probability of fever was greater in the Str.intermedius group compared to the Str.constellatus group(t=4.174,P<0.05).Abscesses were commonly solitary and were located in the parietal and frontal lobes of the brain.Patients with Str.constellatus had a greater probability of developing mixed infections compared to patiens with Str.intermedius(57.14%vs 9.38%)with significant differences(t=14.257,P<0.05).Glycopeptide(vancomycin)plus carbapenem(meropenem)combination regimen was the most commonly used in both empiric and targeted dosing were 64.41%and 52.54%,respectively.No strains resistant to common antibiotics were identified.Conclusion The SAG causing brain abscesses are mainly Str.intermedius and Str.constellatus,and the age,symptoms and infection patterns of patients with brain abscesses caused by the two bacteria were different.SAG did not appear to be drug-resistant in the clinic,and the clinic could reasonably evaluate and adjust the anti-infection regimen based on the drug sensitivity results.

Objective To analyze the clinical characteristics of patients with Streptococcus anginosus group(SAG)infected brain abscess and provide a reference basis for the clinical diagnosis and treatment of this disease.Methods The clinical information of 59 patients with brain abscess with SAG in Guangdong Sanjiu Brain Hospital from January 2016 to October 2023 was collected for retrospective statistical analysis.Results Among the 59 patients with brain abscess,there were 52(88.14%)male and 7(11.86%)female.Among 59 cases of SAG,there were 32(54.24%)in the Str.intermedius group,21(35.59%)in the Str.constellatus group and 6(10.17%)in the Str.anginosus group.The age of Str.intermedius group was less than that of Streptococcus constellatus group(36.75±20.06 years vs 50.43±16.17 years),and the difference was statistically significant(t=2.614,P<0.05).The common clinical symptom was headache,while the probability of fever was greater in the Str.intermedius group compared to the Str.constellatus group(t=4.174,P<0.05).Abscesses were commonly solitary and were located in the parietal and frontal lobes of the brain.Patients with Str.constellatus had a greater probability of developing mixed infections compared to patiens with Str.intermedius(57.14%vs 9.38%)with significant differences(t=14.257,P<0.05).Glycopeptide(vancomycin)plus carbapenem(meropenem)combination regimen was the most commonly used in both empiric and targeted dosing were 64.41%and 52.54%,respectively.No strains resistant to common antibiotics were identified.Conclusion The SAG causing brain abscesses are mainly Str.intermedius and Str.constellatus,and the age,symptoms and infection patterns of patients with brain abscesses caused by the two bacteria were different.SAG did not appear to be drug-resistant in the clinic,and the clinic could reasonably evaluate and adjust the anti-infection regimen based on the drug sensitivity results.