1.A Systems Biology-Based Research Framework for Integrative Traditional Chinese and Western Medicine Studies on Cancer Symptom Clusters
Junfan WU ; Wenjing YANG ; Xueyu WANG ; Zhitong MI ; Shumeng LI ; Kemou CHEN ; Jiarui CAO ; Yingyi WANG ; Guowang YANG
Journal of Traditional Chinese Medicine 2026;67(22):2397-2402
This article proposes a systems biology-based research framework for the cancer symptom clusters （CSCs） within integrative traditional Chinese and western medicine studies. At the ontological level， it argues for the conceptual correspondence between CSCs and traditional Chinese medicine （TCM） syndromes as phenotypic manifestations of complex adaptive systems. At the methodological level， a mapping relationship is established between systems biology approaches and the TCM framework of "disease-syndrome-symptom"， and a five-layer data integration system encompassing disease differentiation， symptom differentiation， syndrome differentiation， omics data， and digital phenotypes is constructed. At the practical level， three major translational pathways are proposed， including molecular network analysis for causal inference， digital phenotype-driven dynamic monitoring， and basket trial design. This framework may provide an operational methodological guide for the integrative study on CSCs and facilitate the transformation of supportive cancer care from fragmented symptom-oriented interventions toward systematic regulation of the overall functional state.
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