The liver is the largest visceral organ in the human body, responsible for multiple important functions such as metabolism, detoxification, nutrient storage, and immune regulation. Hepatocytes located along the portal-central vein axis have heterogeneity in gene expression and function, which led to the concept of liver zonation. Cells in different regions play different roles in metabolic processes, and the coordination and cooperation between these cells are crucial for maintaining normal liver function. In recent years, the advancements in single-cell genomics and spatial transcriptomics technologies have significantly improved our understanding of liver zonation. This article summarizes the important role of metabolic zonation in maintaining liver function and its relationship with disease and aging, providing a theoretical basis for further research and therapeutic strategies.

The liver is the largest visceral organ in the human body, responsible for multiple important functions such as metabolism, detoxification, nutrient storage, and immune regulation. Hepatocytes located along the portal-central vein axis have heterogeneity in gene expression and function, which led to the concept of liver zonation. Cells in different regions play different roles in metabolic processes, and the coordination and cooperation between these cells are crucial for maintaining normal liver function. In recent years, the advancements in single-cell genomics and spatial transcriptomics technologies have significantly improved our understanding of liver zonation. This article summarizes the important role of metabolic zonation in maintaining liver function and its relationship with disease and aging, providing a theoretical basis for further research and therapeutic strategies.

Objective To investigate the level and influence factors of sleep quality for home-care colostomy patients with colorectal cancer. Methods The Pittsburgh sleep quality index were administered on 170 patients with colorectal cancer. Results The score of global Pittsburgh Sleep Quality Index (PSQI) was 7.193±4.355, which was significantly higher than 3.88±2.52 of the norm. And 37.3% (62/166) of colostomy patients with colorectal cancer reported poor sleep quality. 37.3%(62/166) of patients didn′t get 6 hours'sleep every night. The major reasons for sleep disturbance were night toilet visits, 22.3% (37/166) of patients went to night toilet more than 3 times per week. Logistic regression analysis showed that the type of colostomy ( OR=1.969, P=0.012) and discharge time ( OR=2.092, P=0.000) were influencing factors of sleep quality. Conclusion The sleep quality of colostomy patients with colorectal cancer were worse than normal people, and their sleep time were prevalent. The type of colostomy and discharge time were major influencing factors of sleep quality.