Inflammatory bowel disease(IBD)is a chronic and recurrent intestinal inflammatory disease.Interleukin(IL)-22,a member of the IL-10 family,protects the intestinal epithelial barrier and maintains intestinal homeostasis.Multiple studies have demonstrated that IL-22 induces inflammation and promotes inflammatory-cancerous transformation of IBD in different settings.IL-22 is involved in colorectal cancer(CRC)development,and it is a potential anti-cancer therapeutic target.This article reviewed the research progress of IL-22 in IBD.

Objective To investigate the influencing factors of unplanned rehospitalization within one year after surgery among adult renal transplant recipients. Methods The clinical data of 299 recipients who underwent renal transplant surgery in the Department of Organ Transplantation of the Affiliated Hospital of Guizhou Medical University from January 2020 to December 2022 were retrospectively analyzed. The recipients were divided into unplanned rehospitalization group and non-rehospitalization group based on whether they experienced unplanned rehospitalization within one year after surgery. Univariate analysis and binary Logistic regression analysis were performed to explore the influencing factors of unplanned rehospitalization within one year after renal transplantation. Results Among the 299 recipients, 102 experienced unplanned rehospitalization, with an incidence rate of 34.11%. Univariate analysis revealedstatistically significant differences were noted between the two groups in terms of gender, occupational status, preoperative underlying disease, rejection reactions, nosocomial infections, immunosuppressive medication regimens, serum creatinine, cystatin C, serum phosphorus, serum potassium, and initial hospitalization duration (P < 0.05). Binary Logistic regression analysis showed that having ≥3 kinds of preoperative underlying disease (OR=2.122, 95%CI, 1.198 to 3.759) and experiencing rejection reactions (OR=3.162, 95%CI, 1.217 to 8.218) were independent risk factors for unplanned rehospitalization within one year after renal transplantation (P < 0.05). Conclusion The rate of unplanned rehospitalization within one year after surgery is relatively high among adult renal transplant recipients. Having ≥3 preoperative underlying disease and experiencing rejection reactions are independent risk factors for unplanned rehospitalization within one year after surgery. Transplantation healthcare teams can develop corresponding strategies targeting these risk factors to reduce the rate of unplanned rehospitalization and alleviate the burden of disease.

Inflammatory bowel disease(IBD)is a chronic and recurrent intestinal inflammatory disease.Interleukin(IL)-22,a member of the IL-10 family,protects the intestinal epithelial barrier and maintains intestinal homeostasis.Multiple studies have demonstrated that IL-22 induces inflammation and promotes inflammatory-cancerous transformation of IBD in different settings.IL-22 is involved in colorectal cancer(CRC)development,and it is a potential anti-cancer therapeutic target.This article reviewed the research progress of IL-22 in IBD.