The "body schema" of acupuncture and moxibustion is centered on the meridian system and represents a corporeal perspective of "heaven-connection", embodying the harmony between nature and humanity. It integrates the cyclic schema of the heavenly cycling, the meridian growth and decline schema of the guaqi theory, the twelve zodiac demarcation schema from astrological and astronomical studies, and the nine-palace and eight-trigrams schema of temporal and spatial locations. It presents the theoretical origins of the harmony between nature and humanity in acupuncture and moxibustion along with medical thoughts under the background of social concepts. The numerical arts of acupoint number and acupuncture-moxibustion quantity, those of acupuncture-moxibustion time and taboos, as well as the time-based acupuncture-moxibustion patterns, all of these thoroughly reflect the application of the body schema of acupuncture and moxibustion by early medical practitioners in ancient time. The study on the body philosophy in acupuncture and moxibustion should start from the original appearance of early classical acupuncture-moxibustion theory, trace the source of body philosophy of acupuncture and moxibustion, seek the truth of temporal body medicine, and perfect the body philosophy research of contemporary acupuncture and moxibustion, so as to improve the dual attributes of acupuncture and moxibustion in humanities and science.
Moxibustion/history* ; Humans ; Acupuncture Therapy/history* ; History, Ancient ; Meridians ; Astrology

OBJECTIVE:To establish a method for the determination of related substances in Cabazitaxel injection. METHODS:HPLC method was used. The determination was performed on Agilent Eclipse XDB-C18column with mobile phase consisted of water-acetonitrile-ethanol(gradient elution)at the flow rate of 1.0 mL/min. The column temperature was 35 ℃,and the detection wavelength was set at 230 nm. The sample size was 20 μ L. Established method was used to determine related substances in 3 batches of Cabazitaxel injection. RESULTS:The linear relationship of cabazitaxel were 0.039-11.60 μ g/mL(r=0.999 8,n=7). The detection limit was 2×10-4μg,and quantitation limit was 8×10-4μg. RSD of precision and reproducibility tests were all lower than 10.0%(n=6). The amount of single impurity in 3 batches of samples ranged 0.07%-0.08%,and total amount of impurities were 0.26%-0.29%. CONCLUSIONS:Established method is simple,accurate and reliable,can be used for the determination of related substances in Cabazitaxel injection.

Objective To investigate the changes of CD4+,CD8+and B cells in peripheral blood of breast cancer patients detected before and after surgery and following chemotherapy and the relationship with clinical prognosis.Methods Seventy-nine pa-tients with breast cancer who were admitted for treatment in the Department of General Surgery,Shanghai Minhang Central Hospital from July 2015 to March 2017 were enrolled for the study.T cell and B cell counts were detected by flow cytometry in the peripheral blood of breast cancer patients and benign breast cancer patients,and differences were analyzed between the patients of the 2 groups.Then,the relationship between T cell and B cell counts detected in the patients before and after surgery and following chemotherapy and those pa -tients with different TNM staging and molecular typing.Results There were statistical differences in CD4+cell counts and TNM stag-ing between the patients with malignant and benign tumors(P<0.05;P<0.05).There were also statistical differences in CD8+cell counts,when comparisons were made between the patients with malignant and benign tumors, before and after surgery and following chemotherapy,and between different age stages(P<0.05;P<0.05).After chemotherapy, there were statistical differences between different TNM stages(P=0.001)and molecular types(P =0.011).Statistical differences could also be seen in B cells between malignant and benign tumors,between before and after chemotherapy as well as between different age stages(P<0.05;P<0.05;P<0.05).After surgery,statistical differences could also be noted between different TNM stages(P =0.026)and molecular types(P =0.022).CD8+and B cells might be prognostic factors, however, the levels of CD8+and B cells were not necessarily independent predictors of survival after breast cancer treatment.Conclusion The levels of B cells, CD4+and CD8+in peripheral blood have a certain value for the diagnosis and prognosis of breast cancer patients,for this reason,it is worth further research and may promise fu-ture clinical application.