Intrahepatic cholangiocarcinoma (ICC) is the second prevalent primary liver cancer, next to hepatocellular carcinoma. Epidemiologic studies suggest the morbidity of ICC is on the rise worldwide. Owing to the complex etiology, lack of effective screening methods, the concealment of early clinical symptoms and the limited treatment strategy, it is tough to diagnose to ICC and difficult for further treatment. In recent years, with the development of medical technology and the progress of medical treatment idea, active explorations have been made on the early diagnosis and treatment strategies of ICC. The aim of this narrative review is to summarize the research status relating to diagnostic methods and treatment strategies.

Effect of scalding on secretory function of beta-endorphin neuron in the arcuate nucleus of the rat hypothalamus was studied semiquantitatively using immunocytochemistry and image analysis. The results showed that the number of beta-endorphin neurons and area of positive products reduced significantly (P