BACKGROUND: Our previous observational cohort study, the Kashima Scan Study (KSS), identified associations between lifestyle, cerebral small vessel disease (SVD) as detected by magnetic resonance imaging of the brain, and disease outcomes including cognitive impairment and vascular diseases. However, established modifiers of the outcomes such as genetic background, drinking and exercise habits, and socioeconomic status were not considered. Regarding genetic factors in particular, the ALDH2 rs671 variant, East Asian-specific diversity, and APOE status are expected to have strong effects. The aim of KSS-2 is to examine the interactions of genetic background, lifestyle factors including drinking habit, socioeconomic status, and/or SVD markers for cognitive impairment, vascular disease, and death. METHOD: The KSS-2 is a prospective regional observational study of a healthy Japanese cohort that will clarify lifestyle habits to better maintain brain health from midlife by genotype. Japanese adults who underwent brain health checkups at their own expense are enrolled and will be followed-up for 10 years. We will extend the protocol of the KSS to include genetic background and potential confounding factors, including lifestyle (including drinking and exercise habit) and socioeconomic status, and perform survival analyses. The study outcomes are cognitive impairment, vascular events, and death. RESULTS: We enrolled 908 healthy adults (mean age 64.2 years; range 35 to 84 years; 41% male) from September 1, 2018 until December 31, 2024. CONCLUSION This study will provide important insights into the development of individualized health intervention strategies.
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Cerebral Small Vessel Diseases/diagnostic imaging* ; Japan/epidemiology* ; Life Style ; Magnetic Resonance Imaging ; Prospective Studies ; Observational Studies as Topic

It is presumed that oversensitivity to cold is derived from the imbalance of the autonomic nervous system. As a result of the cold condition, the patient may complain of various other problems as well. According to oriental medicine, the main origin of oversensitivity to cold is the invasion of cold, an external evil. In neurometry, this symptom is depicted by low measurement values. Before each treatment session we performed neurometry to assess the patient's condition. Then we performed general Ryodoraku regulation therapy, using a 60mm length, 0.24mm diameter needle as a 200μA (12V) negative electrode for 7 seconds. withI the objective of tonifying and warming the body. In addition, we performed half-rice grain size moxibustion 7 flashing moxas on the special effective extraordinary meridian points. Hanfeng, Lisanli, and main meridian points Fengmen, Zhishi. Neurometry revealed that oversensitivity to cold is related to values of the F, Ryodoraku which are lower than the normal physiological range. The treatment indicated by neurometry proved to be successful in increasing the F, Ryodoraku values.