1.Translational Research in Lymphedema:From Animal Models to the Establishment of Pharmacotherapy
Masaki SANO ; Satoshi HIRAKAWA ; Yurina YOKOYAMA ; Ayumi SHIMODA ; Noriko OGURA ; Shunji TAKASHIMA ; Tetsuyuki NAGAFUSA ; Yusuke OTA ; Shota KAKINUMA ; Katsuya YAMAUCHI ; Hiroya TAKEUCHI ; Masahiro NAKAGAWA
The Japanese Journal of Rehabilitation Medicine 2025;62(9):921-927
2.A Case of Mitral Regurgitation and Aortic Regurgitation Complicated with Coronary Sinus Ostium Stenosis
Satoshi SAKAKIBARA ; Takashi YAMAUCHI ; Reiko KATSUYA
Japanese Journal of Cardiovascular Surgery 2023;52(6):417-421
Retrograde myocardial protection plays an important role in cardiac surgery and is widely used. We herein report a rare cardiac surgical case complicated with small coronary sinus ostium in which the cannula of retrograde cardioplegia could not be inserted. A 58 years old man was referred for the treatment of regurgitation and aortic regurgitation. Preoperative ECG gated computed tomography (CT) showed that the orifice of the largest coronary sinus was located in the right atrium with a diameter of only 4 mm with an other 3 smaller orifice in the right atrium and ventricle, which appeared to make it difficult to perform retrograde myocardial protection. The operative finding was consistent with the preoperative CT finding and mitral valve repair and aortic valve replacement were performed using only selective antegrade myocardial protection. We should bear in mind that small coronary ostium exists and preoperative assessment of the size of coronary sinus might be important.
4.Satisfaction survey of pain management for severe mucositis caused by cancer therapy for head and neck cancer
Naomi Mizukami ; Masanori Yamauchi ; Akihiko Watanabe ; Keiko Danzuka ; Akemi Satoh ; Katsuya Oomori ; Hideo Nakata ; Kazuhiko Koike ; Michiaki Yamakage
Palliative Care Research 2012;7(2):408-414
Purpose: Head and neck cancer patients receiving chemoradiation therapy often suffer from severe mucositis. Chemoradiation therapy-induced mucositis is usually accompanied by severe and intractable pain that impairs quality of life. To establish an effective method for treatment of mucositis pain, we retrospectively investigated the relationships of radiation dose with severity of mucositis and opioid consumption. We also conducted a survey on satisfaction of pain treatment. Methods: Study 1: Fourteen patients who underwent chemoradiation therapy of 70 Gy for head and neck cancer from 2005 to 2009 participated in the study. The relationship of severity of mucositis with opioid use was studied. Study 2: Seven patients who had mucositis of over grade 3 and had completed radiation therapy participated in the study. We carried out a questionnaire survey about satisfaction of each pain treatment. Results: Study 1: Increase of radiation dose significantly worsened the severity of mucositis. Opioid consumption for treating pain was significantly greater in the pharynx cancer group than in the oral cancer group. Study 2: Oral care treatment was preferred to systemic administration of analgesics including opioids. Conclusions: In the oral cancer group, oral care treatment was thought to be useful for pain treatment. Oral cancer patients needed less opioids than did pharynx cancer patients.


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