Objective To explore the characteristics and influencing factors of taste abnormalities in patients with differentiated thyroid cancer(DTC)after 131I treatment.Methods A total of 206 DTC patients who received 131I treatment in the First Affiliated Hospital of Nanchang University from August 2023 to December 2023 were followed up for taste abnormalities,dry mouth,and parotid gland swelling.General clinical data including sex,age,and tumor TNM staging were collected.Based on the presence of taste abnormalities,the patients were divided into abnormal taste group and normal taste group.The differences in general data between the two groups were compared,and multiple logistic regression analysis was used to explore the influencing factors of taste abnor-malities.Results Totally,42.23%of the patients experienced taste abnormalities,including 68 patients with varying degrees of reduced taste,3 patients with a loss of taste,6 patients with taste sensitivity,24 patients with taste hallucinations,and 14 patients with both reduced taste and taste hallucinations.The shortest time for the onset of taste abnormalities was 2 days after 131I treatment,and the longest time was 20 days,with a median time of 7 days;The duration ranged from a minimum of 3 days to a maximum of 60 days,with a median of 14 days.The proportion of dry mouth and parotid gland swelling in patients with abnormal taste was higher than that in those with normal taste,showing statistical significance(P=0.004,0.014,respectively).However,there was no statistical significance in terms of sex age,and tumor TNM stage(P>0.05).Multivariate logistic regression analysis showed that dry mouth and parotid gland swelling were risk factors for taste abnormalities in DTC patients treated with 131I(P=0.007,0.024,respectively).Conclusion Abnormal taste is a common adverse reaction in DTC patients after 131I treatment,typically transient,with a median onset time of 7 days post-treatment and a median duration of 14 days.The primary manifestation is reduced taste,with dry mouth and parotid gland swelling identified as risk factors for its occurrence.

Objective To explore the characteristics and influencing factors of taste abnormalities in patients with differentiated thyroid cancer(DTC)after 131I treatment.Methods A total of 206 DTC patients who received 131I treatment in the First Affiliated Hospital of Nanchang University from August 2023 to December 2023 were followed up for taste abnormalities,dry mouth,and parotid gland swelling.General clinical data including sex,age,and tumor TNM staging were collected.Based on the presence of taste abnormalities,the patients were divided into abnormal taste group and normal taste group.The differences in general data between the two groups were compared,and multiple logistic regression analysis was used to explore the influencing factors of taste abnor-malities.Results Totally,42.23%of the patients experienced taste abnormalities,including 68 patients with varying degrees of reduced taste,3 patients with a loss of taste,6 patients with taste sensitivity,24 patients with taste hallucinations,and 14 patients with both reduced taste and taste hallucinations.The shortest time for the onset of taste abnormalities was 2 days after 131I treatment,and the longest time was 20 days,with a median time of 7 days;The duration ranged from a minimum of 3 days to a maximum of 60 days,with a median of 14 days.The proportion of dry mouth and parotid gland swelling in patients with abnormal taste was higher than that in those with normal taste,showing statistical significance(P=0.004,0.014,respectively).However,there was no statistical significance in terms of sex age,and tumor TNM stage(P>0.05).Multivariate logistic regression analysis showed that dry mouth and parotid gland swelling were risk factors for taste abnormalities in DTC patients treated with 131I(P=0.007,0.024,respectively).Conclusion Abnormal taste is a common adverse reaction in DTC patients after 131I treatment,typically transient,with a median onset time of 7 days post-treatment and a median duration of 14 days.The primary manifestation is reduced taste,with dry mouth and parotid gland swelling identified as risk factors for its occurrence.

Objective To investigate the relationship between carbohydrate antigen(CA)125 level and controlling nutritional status(CONUT)score in patients with primary liver cancer.Methods A total of 195 patients diagnosed with primary liver cancer in the First Affiliated Hospital of Nanchang University from Jan-uary 2016 to January 2020 were selected as the liver cancer group,and 195 healthy people were selected as the control group.CONUT score＜3 points were defined as normal nutrition(normal nutrition group,90 cases),CONUT score ≥3 points were defined as malnutrition(malnutrition group,105 cases).The clinical data and levels of CA125,albumin,lymphocyte count and cholesterol in each group were collected and compared.Spearman correlation analysis was used to analyze the correlation between nutritional status and CA125,and multivariate Logistic regression analysis was used to analyze the influencing factors of liver cancer combined with malnutrition.The receiver operating characteristic(ROC)curve was drawn and the area under the curve(AUC)was calculated to evaluate the ability of CA125 to distinguish malnutrition.Results The level of CA125 in the liver cancer group was higher than that in the control group(P＜0.05),while the lymphocyte count and cholesterol level were lower than those in the control group(P＜0.05).The Child-Pugh score and CA125 level of the malnutrition group were higher than those of the normal nutrition group,and the differ-ences were statistically significant(P＜0.05).Spearman correlation analysis showed that CA125 level was positively correlated with CONUT score and Child-Pugh score(r=0.657,0.647,P＜0.001),and it was nega-tively correlated with albumin,lymphocyte count and cholesterol level(r=-0.623,-0.420,-0.272,P＜0.001).There were significant differences in the COUNT score and the incidence of malnutrition among liver cancer patients with different CA125 levels(P＜0.05).Multivariate Logistic regression analysis showed that elevated CA125 level(≥35 U/mL)was a risk factor for malnutrition in hepatocellular carcinoma(OR=5.560,P=0.002).The ROC curve showed that the AUC of CA125 in the diagnosis of liver cancer combined with malnutrition was 0.826(95％CI 0.768-0.884),the cut-off value of CA125 was 25.99 U/mL,the diag-nostic sensitivity was 73.5％,and the specificity was 81.1％.Conclusion There is a certain relationship be-tween CA125 level and nutritional status in patients with primary liver cancer,and the elevated CA125 level is a risk factor for hepatocellular carcinoma complicated with malnutrition.