Objective Based on Mendelian randomization(MR),the causal relationship between blood lipids and osteoporosis(OP)was explored,with the aim of providing a reference for the prevention and treatment of OP.Methods Data on the relevant lipid profiles and OP associated single nucleotide polymorphisms were extracted from publicly available genome-wide association study(GWAS)databases.Subsequent secondary analysis of the GWAS data was conducted,treating different lipid profiles as exposures and OP as the outcome.The analysis was performed using inverse variance weighted(IVW),MR-Egger,weighted median,and other methods,with Cochran's Q test employed to assess heterogeneity in the MR results.The reliability of the causal relationship was further assessed using the MR-Egger intercept test and the MR-PRESSO test.Results The univariable MR analysis demonstrated significant causal associations between OP and several lipid parameters:total cholesterol(P=0.007,OR=1.003,95％CI:1.001-1.005),triglycerides(P=0.013,OR=0.997,95％CI:0.995-0.999),low density lipoprotein cholesterol(P=0.029,OR=1.002,95％CI:1.000-1.002),and apolipoprotein B(P=0.014,OR=1.003,95％CI:1.001-1.003).There was no significant causal relationship between the other blood lipid types and OP.The multivariable MR analysis revealed no significant causal associations between the eight lipid parameters and OP,while the reverse univariable MR analysis similarly demonstrated no causal relationships between OP and the eight lipid measures.Conclusion Total cholesterol,low density lipoprotein cholesterol and apolipoprotein B are risk factors for OP and will increase the risk of OP onset.Triglycerides have a negative causal correlation with OP,suggesting that it has a potential protective effect.

Objective Based on Mendelian randomization(MR),the causal relationship between blood lipids and osteoporosis(OP)was explored,with the aim of providing a reference for the prevention and treatment of OP.Methods Data on the relevant lipid profiles and OP associated single nucleotide polymorphisms were extracted from publicly available genome-wide association study(GWAS)databases.Subsequent secondary analysis of the GWAS data was conducted,treating different lipid profiles as exposures and OP as the outcome.The analysis was performed using inverse variance weighted(IVW),MR-Egger,weighted median,and other methods,with Cochran's Q test employed to assess heterogeneity in the MR results.The reliability of the causal relationship was further assessed using the MR-Egger intercept test and the MR-PRESSO test.Results The univariable MR analysis demonstrated significant causal associations between OP and several lipid parameters:total cholesterol(P=0.007,OR=1.003,95％CI:1.001-1.005),triglycerides(P=0.013,OR=0.997,95％CI:0.995-0.999),low density lipoprotein cholesterol(P=0.029,OR=1.002,95％CI:1.000-1.002),and apolipoprotein B(P=0.014,OR=1.003,95％CI:1.001-1.003).There was no significant causal relationship between the other blood lipid types and OP.The multivariable MR analysis revealed no significant causal associations between the eight lipid parameters and OP,while the reverse univariable MR analysis similarly demonstrated no causal relationships between OP and the eight lipid measures.Conclusion Total cholesterol,low density lipoprotein cholesterol and apolipoprotein B are risk factors for OP and will increase the risk of OP onset.Triglycerides have a negative causal correlation with OP,suggesting that it has a potential protective effect.

OBJECTIVETo explore the influence of FLT3-ITD mutation and ITD length on the overall survival (OS) and relapse free survival(RFS) in patients with non-M3 acute myeloid leukemia.

METHODSClinical features and therapeutic effect were retrospectively analyzed in 75 AML patients with FLT3-ITD mutation and 76 FLT3-ITD AML patients with a normal karotype from June 2011 to April 2016. Genomic DNA was amplified by PCR, and FLT3-ITD mutation length was analyzed by DNA sequencing in 40 patients.

RESULTSAML patients with FLT3-ITD mutation had higher WBC count and the ratio of BM blast cells at initial diagnosis was also higher than those in AML patients without FLT3-ITD mutation (95.13 vs 10.85)(P<0.01); 72% vs 59%(P<0.01). The CR rates in AML patients with FLT3-ITD mutation less than those in AML patients without FLT3-ITD mutation(70.42% vs 94.7%)(P<0.01). OS (P<0.01) and RFS (P<0.01) were significantly increased in patients with AML who received allo-HSCT as compared with the patients who received consolidation chemotherapy and similar to AML patients without FLT3-ITD mutation who received HSCT. Patients with maintenance sorafenib after HSCT had longer OS (P<0.05) and RFS (P<0.05) than controls. ITDs exceeding 60 bp in length were associated with decreasing OS as compared with shorter ITD in AML patients with FLT3-ITD mutation (P<0.05). OS and RFS were similar among the 2 groups receiving consolidation chemotherapy. Besides, the patients with allo-HSCT had shorter ITDs and longer OS than ITDs exceeding 60 bp (P<0.05) and similar to AML patients without FLT3-ITD mutation.

CONCLUSIONAML patients with FLT3-ITD mutation has poorer outcome, among which the prognosis was worse in patients with ITD exceeding 60 bp, and the chemotherapy alone can not improve the prognosis of FLT3-ITD. Allo-HSCT is an effective treatment for AML patients with FLT3-ITD mutation; Sorafenib appears to be an effective maintenance therapy after allo-HSCT in FLT3-ITD AML.

Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute ; Mutation ; Oncogene Proteins, Fusion ; Prognosis ; Retrospective Studies ; fms-Like Tyrosine Kinase 3

The standardized training is an indispensible stage for the improvement of residents' comprehensive quality and for the training of high-qualified talents.The article preliminarily explored the standardized training model for residents,which was in accordance with the characteristics of the department of cardiology mainly from four aspects:the set-up of reasonable training program,the training of practical skills,the training of humanistic quality and the training of life-long learning ability.

OBJECTIVETo investigate the clinical effect of the Chinese medicinal preparation Shengling Capsule on patients with oligoasthenospermia.

METHODSA total of 270 male patients with infertility induced by oligoasthenospermia were equally divided into a treatment and a control group, the former medicated with Shengling Capsule at the dose of 1.6 g tid, and the latter given Vit E at 50 mg tid, both for a course of 12 weeks. Then we analyzed the changes in the patients'seminal parameters and the pregnancy of their wives.

RESULTSAfter 12 weeks of medication, both the seminal parameters of the patients and pregnancy of their wives were remarkably improved, with extremely significant differences from pre-treatment and the control (P < 0.01).

CONCLUSIONShengjing Capsule can improve sperm motility and vitality as well as sperm count. With few adverse effects, it can be used as a safe and effective therapeutic for male infertility induced by oligoasthenospermia.

Adult ; Asthenozoospermia ; drug therapy ; Humans ; Male ; Oligospermia ; drug therapy ; Phytotherapy ; Treatment Outcome