Objective To explore the clinical value of blood urea nitrogen(BUN)combined with carbon dioxide binding power(CO2-CP)in predicting the short-term prognosis in the patients with acute ischemic stroke(AIS)undergoing intravenous thrombolysis.Methods The medical case data of 238 patients with AIS treated by recombinant tissue plasminogen activator(rt-PA)intravenous thrombolysis in the neurology de-partment of the First Affiliated Hospital of Nanyang Medical College from January 2023 to January 2024 were retrospectively analyzed.The general data and laboratory test results were collected.The general data and la-boratory detection results were collected.According to the results of modified Rankin Scale(mRS)on 90 d,the patients were divided into the good prognosis group(mRS＜3 points,157 cases)and poor prognosis group(mRS≥3 points,81 cases).The levels of WBC count,RBC count,PLT,Na+,K+,TC,TG,HDL-C,Fib,D-di-mer,HCY,BUN,Cr,UA,UA/Cr ratio and CO2-CP before intravenous thrombolysis were compared between the two groups.The multivariate logistic regression was used to analyze the risk factors of poor prognosis in the patients with AIS intravenous thrombolysis treatment.The receiver operating characteristic(ROC)curve was drawn to evaluate the predictive value of the corresponding indicators in the short-term prognosis of the AIS patients with intravenous thrombolysis treatment.Results The NIHSS score,Glu,BUN and CO2-CP lev-els at admission had statistically significant difference between the two groups(P＜0.05).The multivariate logistic regression analysis results showed that BUN(OR=1.308,95％CI:1.119-1.528)and CO2-CP(OR=0.676,95％CI:0.589-0.776)were the independently influencing factors for the short-term prognosis in the patients with AIS intravenous thrombolysis treatment.The ROC curve analysis results showed that the area under the curve(AUC)of BUN and CO2-CP combination in the evaluation of short-term poor prognosis in the patients with AIS intravenous thrombolysis treatment was 0.850,the 95％CI was 0.800-0.901,the sensitivity was 79.0％,the specificity was 82.8％,which had good predictive value.Conclusion The combina-tion of BUN and CO2-CP in predicting the short-term prognosis of the patients with AIS intravenous throm-bolysis treatment has the higher clinical value.