1.Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 5. Evaluation of Recurrence Risk Postoperatively and Initial Risk Stratification in Differentiated Thyroid Cancer 2024
Eun Kyung LEE ; Young Shin SONG ; Ho-Cheol KANG ; Sun Wook KIM ; Dong Gyu NA ; Shin Je MOON ; Dong-Jun LIM ; Kyong Yeun JUNG ; Yun Jae CHUNG ; Chan Kwon JUNG ; Young Joo PARK ;
International Journal of Thyroidology 2025;18(1):111-112
2.2025 Korean Thyroid Association Clinical Management Guideline on Active Surveillance for Low-Risk Papillary Thyroid Carcinoma
Eun Kyung LEE ; Min Joo KIM ; Seung Heon KANG ; Bon Seok KOO ; Kyungsik KIM ; Mijin KIM ; Bo Hyun KIM ; Ji-hoon KIM ; Shin Je MOON ; Kyorim BACK ; Young Shin SONG ; Jong-hyuk AHN ; Hwa Young AHN ; Ho-Ryun WON ; Won Sang YOO ; Min Kyoung LEE ; Jeongmin LEE ; Ji Ye LEE ; Kyong Yeun JUNG ; Chan Kwon JUNG ; Yoon Young CHO ; Dong-Jun LIM ; Sun Wook KIM ; Young Joo PARK ; Dong Gyu NA ; Jee Soo KIM
International Journal of Thyroidology 2025;18(1):30-64
The increasing detection of papillary thyroid microcarcinoma (PTMC) has raised concerns about overtreatment.For low-risk PTMC, either immediate surgery or active surveillance (AS) can be considered. To support AS implementation, the Korean Thyroid Association convened a multidisciplinary panel and developed the first Korean guideline. AS is recommended to adults with pathologically proven Bethesda V-VI PTMC without clinical evidence of lymph node or distant metastasis, gross extrathyroidal extension, tracheal or recurrent laryngeal nerve invasion, or aggressive histology. Baseline assessment requires high‑resolution cervical ultrasound by experienced operators to rule out extrathyroidal extension, tracheal or recurrent laryngeal nerve invasion, and lymph node metastasis;contrast‑enhanced neck computed tomography is optional. Patient characteristics such as age, comorbidities, and capacity for long-term follow-up should be assessed. Shared decision-making should weigh the benefits and risks of surgery and AS, expected oncologic outcomes, complications, quality of life, anxiety, medical cost, and patient preference. Follow-up includes cervical ultrasound and thyroid function test every six months for two years, then annually. Disease progression, defined as significant tumor growth or newly detected nodal or distant metastasis, warrants surgery. Despite remaining uncertainties, this guideline offers a framework to ensure oncologic safety and support patient-centered active surveillance.
3.Analysis of Choroidal Thickness Changes in Recurrent Rhegmatogenous Retinal Detachment
Gyu Chul CHUNG ; Soo Jung LEE ; Kang Yeun PAK
Korean Journal of Ophthalmology 2024;38(6):489-495
Purpose:
To analyze changes in choroidal thickness in patients with recurrent rhegmatogenous retinal detachment (RRD) before and after surgical intervention and to identify factors that influence changes in choroidal thickness.
Methods:
A retrospective observational study was conducted on patients who underwent surgery for recurrent RRD from November 2019 to March 2023. Choroidal thickness was measured using optical coherence tomography at baseline and at 2 and 6 months postoperatively. The study analyzed the impact of various factors on choroidal thickness changes.
Results:
The study included 33 patients, demonstrating a significant decrease in choroidal thickness in the surgical eye compared to the fellow eye over a 6-month period. In the univariate analysis, changes in choroidal thickness were significantly correlated with changes in central retinal thickness (p = 0.048) from baseline to 2 months and with proliferative vitreoretinopathy (PVR) grade from 2 to 6 months (p = 0.009) and from baseline to 6 months (p = 0.020). In the multivariate analysis, an association was found between changes in choroidal thickness from 2 to 6 months and PVR grade (p = 0.030)
Conclusions
The findings indicate that surgical reattachment in eyes with recurrent RRD leads to a significant reduction in choroidal thickness. The extent of this reduction is influenced by the severity of PVR, highlighting the importance of considering PVR severity when evaluating surgical outcomes in patients with recurrent RRD.
4.Effect of thyroid-stimulating hormone suppression on quality of life in thyroid lobectomy patients: interim analysis of a multicenter, randomized controlled trial in low- to intermediate-risk thyroid cancer patients (MASTER study)
Ja Kyung LEE ; Eu Jeong KU ; Su-jin KIM ; Woochul KIM ; Jae Won CHO ; Kyong Yeun JUNG ; Hyeong Won YU ; Yea Eun KANG ; Mijin KIM ; Hee Kyung KIM ; Junsun RYU ; June Young CHOI ;
Annals of Surgical Treatment and Research 2024;106(1):19-30
Purpose:
Current clinical practices favor less or no thyroid-stimulating hormone (TSH) suppression for low- to intermediate-risk thyroid cancer patients who receive thyroid lobectomy. The association of TSH suppression on healthrelated quality of life (HR-QoL) in patients after thyroid lobectomy is not well studied. This study aimed to evaluate the effect of TSH suppression on patient HR-QoL after thyroid lobectomy.
Methods:
This study included patients enrolled in an ongoing, multicenter, randomized controlled study investigating the effects of TSH suppression. Patients were randomized to either the low-TSH group (TSH target range, 0.3–1.99 μIU/ mL) or the high-TSH group (TSH target range, 2.0–7.99 μIU/mL). The HR-QoL, hyperthyroidism symptom, and depression symptom questionnaires performed preoperatively and 2 weeks and 3 months postoperatively were evaluated.
Results:
Total of 669 patients (low-TSH group, 340; high-TSH group, 329) were included. Although total HR-QoL score changes were not different between the 2 groups, the high-TSH group had a significantly higher score in the physical domain at postoperative 3 months (P = 0.046). The 2 groups did not have significant differences in hyperthyroidism and depression scores.
Conclusion
In the short-term postoperative period, the physical HR-QoL scores in thyroid lobectomy patients were better when they did not receive TSH suppression. This study suggests the importance of considering HR-QoL when setting TSH suppression targets in thyroid lobectomy patients.
5.Accuracy of interocclusal record established by different occlusal scans
Minjee KANG ; Cheong-Hee LEE ; Kyu-Bok LEE ; So-Yeun KIM ; Du-Hyeong LEE
Journal of Dental Rehabilitation and Applied Science 2024;40(3):142-148
Purpose:
The purpose of this study was to investigate the accuracy of digital mounting with occlusal scans in the interocclusal record for a full-mouth fixed prosthetic treatment condition.
Materials and Methods:
The entire maxillary teeth were prepared in a dentiform model and attached to an articulator in maximum intercuspation. Temporary crowns were fabricated and occlusion was adjusted. After scanning the arch with tooth preparation, digital mounting was performed using an occlusion scan of the anterior or posterior teeth areas. The accuracy of the positioned jaw relation was evaluated three-dimensionally through positional deviation and angular error of the occlusal plane. Afterwards, the same procedure was repeated on the partially edentulous model to evaluate the accuracy of digital interocclusal record. Kruskal-Wallis test and Mann-Whitney U test were used for statistical analysis, and the significance level was set at 0.05.
Results:
There was no significant difference in the positional error at the centerof the arch in the digitally established jaw relation depending on the scan area used and remaining tooth conditions (P = 0.53). Theangular error of the occlusal plane was larger when the anterior teeth were used as the overlapping area, and a smaller error value was observed when both posterior teeth were used as the overlapping area (P < 0.001).
Conclusion
The use of bilateral posterior occlusal scans is recommended when digitally mounting the jaw relation established with temporary teeth during full-mouth fixed prosthetic treatment.
6.Analysis of Choroidal Thickness Changes in Recurrent Rhegmatogenous Retinal Detachment
Gyu Chul CHUNG ; Soo Jung LEE ; Kang Yeun PAK
Korean Journal of Ophthalmology 2024;38(6):489-495
Purpose:
To analyze changes in choroidal thickness in patients with recurrent rhegmatogenous retinal detachment (RRD) before and after surgical intervention and to identify factors that influence changes in choroidal thickness.
Methods:
A retrospective observational study was conducted on patients who underwent surgery for recurrent RRD from November 2019 to March 2023. Choroidal thickness was measured using optical coherence tomography at baseline and at 2 and 6 months postoperatively. The study analyzed the impact of various factors on choroidal thickness changes.
Results:
The study included 33 patients, demonstrating a significant decrease in choroidal thickness in the surgical eye compared to the fellow eye over a 6-month period. In the univariate analysis, changes in choroidal thickness were significantly correlated with changes in central retinal thickness (p = 0.048) from baseline to 2 months and with proliferative vitreoretinopathy (PVR) grade from 2 to 6 months (p = 0.009) and from baseline to 6 months (p = 0.020). In the multivariate analysis, an association was found between changes in choroidal thickness from 2 to 6 months and PVR grade (p = 0.030)
Conclusions
The findings indicate that surgical reattachment in eyes with recurrent RRD leads to a significant reduction in choroidal thickness. The extent of this reduction is influenced by the severity of PVR, highlighting the importance of considering PVR severity when evaluating surgical outcomes in patients with recurrent RRD.
7.Analysis of Choroidal Thickness Changes in Recurrent Rhegmatogenous Retinal Detachment
Gyu Chul CHUNG ; Soo Jung LEE ; Kang Yeun PAK
Korean Journal of Ophthalmology 2024;38(6):489-495
Purpose:
To analyze changes in choroidal thickness in patients with recurrent rhegmatogenous retinal detachment (RRD) before and after surgical intervention and to identify factors that influence changes in choroidal thickness.
Methods:
A retrospective observational study was conducted on patients who underwent surgery for recurrent RRD from November 2019 to March 2023. Choroidal thickness was measured using optical coherence tomography at baseline and at 2 and 6 months postoperatively. The study analyzed the impact of various factors on choroidal thickness changes.
Results:
The study included 33 patients, demonstrating a significant decrease in choroidal thickness in the surgical eye compared to the fellow eye over a 6-month period. In the univariate analysis, changes in choroidal thickness were significantly correlated with changes in central retinal thickness (p = 0.048) from baseline to 2 months and with proliferative vitreoretinopathy (PVR) grade from 2 to 6 months (p = 0.009) and from baseline to 6 months (p = 0.020). In the multivariate analysis, an association was found between changes in choroidal thickness from 2 to 6 months and PVR grade (p = 0.030)
Conclusions
The findings indicate that surgical reattachment in eyes with recurrent RRD leads to a significant reduction in choroidal thickness. The extent of this reduction is influenced by the severity of PVR, highlighting the importance of considering PVR severity when evaluating surgical outcomes in patients with recurrent RRD.
8.Analysis of Choroidal Thickness Changes in Recurrent Rhegmatogenous Retinal Detachment
Gyu Chul CHUNG ; Soo Jung LEE ; Kang Yeun PAK
Korean Journal of Ophthalmology 2024;38(6):489-495
Purpose:
To analyze changes in choroidal thickness in patients with recurrent rhegmatogenous retinal detachment (RRD) before and after surgical intervention and to identify factors that influence changes in choroidal thickness.
Methods:
A retrospective observational study was conducted on patients who underwent surgery for recurrent RRD from November 2019 to March 2023. Choroidal thickness was measured using optical coherence tomography at baseline and at 2 and 6 months postoperatively. The study analyzed the impact of various factors on choroidal thickness changes.
Results:
The study included 33 patients, demonstrating a significant decrease in choroidal thickness in the surgical eye compared to the fellow eye over a 6-month period. In the univariate analysis, changes in choroidal thickness were significantly correlated with changes in central retinal thickness (p = 0.048) from baseline to 2 months and with proliferative vitreoretinopathy (PVR) grade from 2 to 6 months (p = 0.009) and from baseline to 6 months (p = 0.020). In the multivariate analysis, an association was found between changes in choroidal thickness from 2 to 6 months and PVR grade (p = 0.030)
Conclusions
The findings indicate that surgical reattachment in eyes with recurrent RRD leads to a significant reduction in choroidal thickness. The extent of this reduction is influenced by the severity of PVR, highlighting the importance of considering PVR severity when evaluating surgical outcomes in patients with recurrent RRD.
9.Accuracy of interocclusal record established by different occlusal scans
Minjee KANG ; Cheong-Hee LEE ; Kyu-Bok LEE ; So-Yeun KIM ; Du-Hyeong LEE
Journal of Dental Rehabilitation and Applied Science 2024;40(3):142-148
Purpose:
The purpose of this study was to investigate the accuracy of digital mounting with occlusal scans in the interocclusal record for a full-mouth fixed prosthetic treatment condition.
Materials and Methods:
The entire maxillary teeth were prepared in a dentiform model and attached to an articulator in maximum intercuspation. Temporary crowns were fabricated and occlusion was adjusted. After scanning the arch with tooth preparation, digital mounting was performed using an occlusion scan of the anterior or posterior teeth areas. The accuracy of the positioned jaw relation was evaluated three-dimensionally through positional deviation and angular error of the occlusal plane. Afterwards, the same procedure was repeated on the partially edentulous model to evaluate the accuracy of digital interocclusal record. Kruskal-Wallis test and Mann-Whitney U test were used for statistical analysis, and the significance level was set at 0.05.
Results:
There was no significant difference in the positional error at the centerof the arch in the digitally established jaw relation depending on the scan area used and remaining tooth conditions (P = 0.53). Theangular error of the occlusal plane was larger when the anterior teeth were used as the overlapping area, and a smaller error value was observed when both posterior teeth were used as the overlapping area (P < 0.001).
Conclusion
The use of bilateral posterior occlusal scans is recommended when digitally mounting the jaw relation established with temporary teeth during full-mouth fixed prosthetic treatment.
10.Accuracy of interocclusal record established by different occlusal scans
Minjee KANG ; Cheong-Hee LEE ; Kyu-Bok LEE ; So-Yeun KIM ; Du-Hyeong LEE
Journal of Dental Rehabilitation and Applied Science 2024;40(3):142-148
Purpose:
The purpose of this study was to investigate the accuracy of digital mounting with occlusal scans in the interocclusal record for a full-mouth fixed prosthetic treatment condition.
Materials and Methods:
The entire maxillary teeth were prepared in a dentiform model and attached to an articulator in maximum intercuspation. Temporary crowns were fabricated and occlusion was adjusted. After scanning the arch with tooth preparation, digital mounting was performed using an occlusion scan of the anterior or posterior teeth areas. The accuracy of the positioned jaw relation was evaluated three-dimensionally through positional deviation and angular error of the occlusal plane. Afterwards, the same procedure was repeated on the partially edentulous model to evaluate the accuracy of digital interocclusal record. Kruskal-Wallis test and Mann-Whitney U test were used for statistical analysis, and the significance level was set at 0.05.
Results:
There was no significant difference in the positional error at the centerof the arch in the digitally established jaw relation depending on the scan area used and remaining tooth conditions (P = 0.53). Theangular error of the occlusal plane was larger when the anterior teeth were used as the overlapping area, and a smaller error value was observed when both posterior teeth were used as the overlapping area (P < 0.001).
Conclusion
The use of bilateral posterior occlusal scans is recommended when digitally mounting the jaw relation established with temporary teeth during full-mouth fixed prosthetic treatment.

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