Objective:To develop a treatment-related quality of life scale for Chinese patients with multiple myeloma (MM) and to test its reliability and validity.Methods:The initial scale was constructed through a literature search, Delphi expert correspondence, and cognitive testing. This study conducted a preliminary survey of 379 patients with MM and a formal survey of 865 patients from the hematology departments of 155 hospitals nationwide from February 2024 to March 2024. The final scale was obtained after conducting item analysis and reliability and validity tests on the initial scale.Results:The constructed scale contains 36 items covering six domains: physiological, psychological, social, treatment side effects, general health, and others. In the preliminary survey, the Cronbach’s alpha coefficient of each item ranged from 0.597 to 0.939, and the test-retest reliability was 0.747 ( P<0.001). Exploratory factor analysis extracted eight common factors with a cumulative variance contribution of 60.058%. In the formal survey, the Cronbach’s alpha coefficient of each item ranged from 0.484 to 0.930, and the test-retest reliability was 0.835 ( P<0.001). Confirmatory factor analysis revealed a comparative fit index of 0.750, a root-mean-square error of approximation of 0.090, and a root-mean-square residual of 0.067. Conclusion:The treatment-related quality of life scale for Chinese patients with MM designed in this study exhibited good reliability and validity, reflecting the impact of treatment on the quality of life of patients. This scale can provide a reference to clinicians for assessing the disease status of patients.

Objective To analyze the fluid resistance characteristics of different drafting formations in marathon swimming using computational fluid dynamics(CFD)method,and provide theoretical guidance for selecting optimal drafting strategies in competitions and training.Methods Multi-swimmer models were established via three-dimensional body scanning technology,and various formation models(I-,A-,V-,L-,H-type)were created by adjusting lateral and longitudinal distances between swimmers.The ANSYS Discovery Live software was used to simulate the overall resistance of different models and the resistance of individual swimmers within formations.Results The I3-type formation exhibited an overall drag reduction effect,reducing total resistance by 55.21％,whereas other formations increased overall resistance.The V-type formation showed the most significant resistance increase(31.88％).During drafting,the lowest resistance position was the rear position in the I3-type formation,while the highest resistance position was the middle position in the L-type formation.When leading,the fluid resistance of the leading swimmer in the A-type formation was significantly greater than that of an individual swimmer(P＜0.05).Conclusions Longitudinal drafting formations demonstrated superior drag reduction effects,with the rear position in a three-person longitudinal arrangement showing the optimal drag reduction.Considering both tactical considerations and drag reduction effects,swimmers are advised to avoid the middle position in lateral formations.

Objective To analyze the fluid resistance characteristics of different drafting formations in marathon swimming using computational fluid dynamics(CFD)method,and provide theoretical guidance for selecting optimal drafting strategies in competitions and training.Methods Multi-swimmer models were established via three-dimensional body scanning technology,and various formation models(I-,A-,V-,L-,H-type)were created by adjusting lateral and longitudinal distances between swimmers.The ANSYS Discovery Live software was used to simulate the overall resistance of different models and the resistance of individual swimmers within formations.Results The I3-type formation exhibited an overall drag reduction effect,reducing total resistance by 55.21％,whereas other formations increased overall resistance.The V-type formation showed the most significant resistance increase(31.88％).During drafting,the lowest resistance position was the rear position in the I3-type formation,while the highest resistance position was the middle position in the L-type formation.When leading,the fluid resistance of the leading swimmer in the A-type formation was significantly greater than that of an individual swimmer(P＜0.05).Conclusions Longitudinal drafting formations demonstrated superior drag reduction effects,with the rear position in a three-person longitudinal arrangement showing the optimal drag reduction.Considering both tactical considerations and drag reduction effects,swimmers are advised to avoid the middle position in lateral formations.

Objective:To develop a treatment-related quality of life scale for Chinese patients with multiple myeloma (MM) and to test its reliability and validity.Methods:The initial scale was constructed through a literature search, Delphi expert correspondence, and cognitive testing. This study conducted a preliminary survey of 379 patients with MM and a formal survey of 865 patients from the hematology departments of 155 hospitals nationwide from February 2024 to March 2024. The final scale was obtained after conducting item analysis and reliability and validity tests on the initial scale.Results:The constructed scale contains 36 items covering six domains: physiological, psychological, social, treatment side effects, general health, and others. In the preliminary survey, the Cronbach’s alpha coefficient of each item ranged from 0.597 to 0.939, and the test-retest reliability was 0.747 ( P<0.001). Exploratory factor analysis extracted eight common factors with a cumulative variance contribution of 60.058%. In the formal survey, the Cronbach’s alpha coefficient of each item ranged from 0.484 to 0.930, and the test-retest reliability was 0.835 ( P<0.001). Confirmatory factor analysis revealed a comparative fit index of 0.750, a root-mean-square error of approximation of 0.090, and a root-mean-square residual of 0.067. Conclusion:The treatment-related quality of life scale for Chinese patients with MM designed in this study exhibited good reliability and validity, reflecting the impact of treatment on the quality of life of patients. This scale can provide a reference to clinicians for assessing the disease status of patients.

Objective:To evaluate the efficacy and safety of mitoxantrone hydrochloride liposome injection in the treatment of peripheral T-cell lymphoma (PTCL) in a real-world setting.Methods:This was a real-world ambispective cohort study (MOMENT study) (Chinese clinical trial registry number: ChiCTR2200062067). Clinical data were collected from 198 patients who received mitoxantrone hydrochloride liposome injection as monotherapy or combination therapy at 37 hospitals from January 2022 to January 2023, including 166 patients in the retrospective cohort and 32 patients in the prospective cohort; 10 patients in the treatment-na?ve group and 188 patients in the relapsed/refractory group. Clinical characteristics, efficacy and adverse events were summarized, and the overall survival (OS) and progression-free survival (PFS) were analyzed.Results:All 198 patients were treated with mitoxantrone hydrochloride liposome injection for a median of 3 cycles (range 1-7 cycles); 28 cases were treated with mitoxantrone hydrochloride liposome injection as monotherapy, and 170 cases were treated with the combination regimen. Among 188 relapsed/refractory patients, 45 cases (23.9%) were in complete remission (CR), 82 cases (43.6%) were in partial remission (PR), and 28 cases (14.9%) were in disease stabilization (SD), and 33 cases (17.6%) were in disease progression (PD), with an objective remission rate (ORR) of 67.6% (127/188). Among 10 treatment-na?ve patients, 4 cases (40.0%) were in CR, 5 cases (50.0%) were in PR, and 1 case (10.0%) was in PD, with an ORR of 90.0% (9/10). The median follow-up time was 2.9 months (95% CI 2.4-3.7 months), and the median PFS and OS of patients in relapsed/refractory and treatment-na?ve groups were not reached. In relapsed/refractory patients, the difference in ORR between patients with different number of treatment lines of mitoxantrone hydrochloride liposome injection [ORR of the second-line, the third-line and ≥the forth-line treatment was 74.4% (67/90), 73.9% (34/46) and 50.0% (26/52)] was statistically significant ( P = 0.008). Of the 198 PTCL patients, 182 cases (91.9%) experienced at least 1 time of treatment-related adverse events, and the incidence rate of ≥grade 3 adverse events was 66.7% (132/198), which was mainly characterized by hematologic adverse events. The ≥ grade 3 hematologic adverse events mainly included decreased lymphocyte count, decreased neutrophil count, decreased white blood cell count, and anemia; non-hematologic adverse events were mostly grade 1-2, mainly including pigmentation disorders and upper respiratory tract infection. Conclusions:The use of mitoxantrone hydrochloride liposome injection-containing regimen in the treatment of PTCL has definite efficacy and is well tolerated, and it is a new therapeutic option for PTCL patients.

ObjectiveTo systematically analyze the effect of therapeutic exercise on neck function and quality of life in patients with neck pain and forward head posture. MethodsRandomized controlled trials about the effects of exercise training on forward head posture and neck pain were searched from PubMed, Web of science, Embase, Medline, Science Direct, EBSCO, Springlink, CNKI, VIP, and Wanfang Data from database establishment to April, 2022. The literature was screened by two researchers independently. Cochrane bias risk assessment tool and Physiotherapy Evidence Database Scale were used to evaluate the quality of the included articles. Revman 5.4 software was used for meta-analysis. ResultsA total of 416 patients from eleven literatures were included. Level 1a evidence indicated scapula stability training could effectively improve cranial vertebral angle (MD = 3.62, 95%CI 2.41 to 4.83, P < 0.001), and relieve pain (MD = 1.32, 95%CI 0.18 to 2.46, P = 0.02). Level 1b evidence indicated scapula stability training could reduce functional disability (MD = -0.92, 95%CI -1.11 to -0.74, P < 0.001). Level 1b evidence indicated deep cervical flexor training could improve cranial vertebral angle (MD = -0.83, 95%CI -1.56 to -0.10, P = 0.03), relieve pain (MD = 0.93, 95%CI 0.54 to 1.32, P < 0.001), and improve neck functional disability (MD = 2.17, 95%CI 1.39 to 2.95, P < 0.001). ConclusionScapula stability training and deep cervical flexor training can effectively improve cranial vertebral angle, relieve neck pain, and improve neck function.

ObjectiveTo explore the effect of exercise on the postural control and muscular function around the ankle in patients with functional ankle instability (FAI) with meta-analysis. MethodsRandomized controlled trials about therapeutic exercise for FAI published before December, 2021 were searched from PubMed, EBSCO, SPORTdiscus, Medline, Science Direct, Springlink, Web of Science, Embase CNKI, VIP and Wanfang Data. The quality and evidence grades of the researches were evaluated by two researchers, and the outcomes were analyzed with RevMan 5.4. ResultsFourteen randomized controlled trials were finally included, involving 434 subjects. Compared with no exercise intervention, therapeutic exercise might significantly improve the movement of center of pressure whether with eye-open or eye-closed (eye-open, SMD = -0.28, 95%CI -0.46 to -0.09, P = 0.003; eye-closed, SMD = -0.24, 95%CI -0.40 to -0.09, P = 0.001); while therapeutic exercise might also enhance the activation of the peroneus longus before dynamic task (SMD = 0.38, 95%CI 0.05 to 0.71, P = 0.03), and activation of the peroneus longus (SMD = 0.53, 95%CI 0.16 to 0.90, P = 0.005) and tibialis anterior (SMD = 0.47, 95%CI 0.10 to 0.84, P = 0.01) after dynamic task. There was neither significant difference in the activation of the tibialis anterior (SMD = 0.48, 95%CI -0.14 to 1.11, P = 0.13), nor the peak torque ratio of eversion to inversion isokinetic strength (SMD = -0.15, 95%CI -0.46 to 0.16, P = 0.340) before dynamic task between the two groups. ConclusionTherapeutic exercise can decrease movement of center of pressure, enable anticipatory contraction of peroneus longus before dynamic tasks and compensatory contraction of peroneus longus and tibialis anterior after tasks, to make it easier to deal with external interference, maintain articular stability and prevent re-injury.

Objective:To study the features and regularity of the diseases occurred among the officers and sailors of a certain large surface ship during a long oceangoing mission, and to provide some targeted preventive measures for improving the medical support in long oceangoing mission in future.Methods:A retrospective survey was conducted on the medical records of outpatient, emergence, and onboard medical inspection by classifying all the cases into different medical disciplines, to analyze the features of disease distribution and regularity among the crew members during a long oceangoing mission.Results:There were 673 case/times were included into this analysis from the 81-day-long 549-people-participation oceangoing mission. The top 3 disorders involved in the respiratory system, the motor system (trauma), and the digestive system, accounting for 70.58% of the total cases. Among them, the upper respiratory tract infection, hand injury, and oral ulcer accounted for 21.86%, 5.65%, and 5.28% of the disease spectrum respectively. The incidence of diseases requiring surgery and further medical care was relatively higher (24.59%), especially trauma and infectious diseases as the prevalent disorders, concentrating on the motor system and digestive system.Conclusion:The disease spectrum during the long oceangoing was related with the onboard living environment, individual body constitution, individual history of long oceangoing deployment, and gender difference. With regard to disease control, the efforts should be devoted to health education and disinfection of onboard environment, especially preventing infectious diseases. Personal health records and pre-warning of disease outbreak system should also be established if necessary. Meanwhile, the manning of medical team and the preparation of medical supplies should conform to the features and distribution regularity of diseases spectrum during a long oceangoing mission.

Objective:To study the features and regularity of the diseases occurred among the officers and sailors of a certain large surface ship during a long oceangoing mission, and to provide some targeted preventive measures for improving the medical support in long oceangoing mission in future.Methods:A retrospective survey was conducted on the medical records of outpatient, emergence, and onboard medical inspection by classifying all the cases into different medical disciplines, to analyze the features of disease distribution and regularity among the crew members during a long oceangoing mission.Results:There were 673 case/times were included into this analysis from the 81-day-long 549-people-participation oceangoing mission. The top 3 disorders involved in the respiratory system, the motor system (trauma), and the digestive system, accounting for 70.58% of the total cases. Among them, the upper respiratory tract infection, hand injury, and oral ulcer accounted for 21.86%, 5.65%, and 5.28% of the disease spectrum respectively. The incidence of diseases requiring surgery and further medical care was relatively higher (24.59%), especially trauma and infectious diseases as the prevalent disorders, concentrating on the motor system and digestive system.Conclusion:The disease spectrum during the long oceangoing was related with the onboard living environment, individual body constitution, individual history of long oceangoing deployment, and gender difference. With regard to disease control, the efforts should be devoted to health education and disinfection of onboard environment, especially preventing infectious diseases. Personal health records and pre-warning of disease outbreak system should also be established if necessary. Meanwhile, the manning of medical team and the preparation of medical supplies should conform to the features and distribution regularity of diseases spectrum during a long oceangoing mission.