Objective:To summarize the clinical characteristics of patients with ulcerative colitis (UC) who developed joint manifestations after receiving vedolizumab (VDZ) .Methods:Patients with UC who developed joint manifestations after receiving VDZ at Sir Run Run Shaw Hospital, Zhejiang University School of Medicine from November 2020 to October 2021 were retrospectively included. Cases previously reported in the literature were revieved.Results:Four patients with UC were included, none of whom had extraintestinal manifestations previously. After receiving VDZ, four patients developed joint pain, and three had polyarticular involvement. Three patients had elevated C-reactive protein (CRP) and ultrasonography indicated joint effusion. No one discontinued due to the worsening of arthropathy and the joint manifestations all improved after treatment.Conclusion:Arthropathy may be induced after receiving VDZ, manifesting as elevated CRP, joint effusion, and bone marrow edema. After treatment with nonsteroidal anti-inflammatory drugs, glucocorticoids, immunosuppressants, or biological agents, most of the patients had a favorable prognosis.

Objective:To summarize the clinical characteristics of patients with ulcerative colitis (UC) who developed joint manifestations after receiving vedolizumab (VDZ) .Methods:Patients with UC who developed joint manifestations after receiving VDZ at Sir Run Run Shaw Hospital, Zhejiang University School of Medicine from November 2020 to October 2021 were retrospectively included. Cases previously reported in the literature were revieved.Results:Four patients with UC were included, none of whom had extraintestinal manifestations previously. After receiving VDZ, four patients developed joint pain, and three had polyarticular involvement. Three patients had elevated C-reactive protein (CRP) and ultrasonography indicated joint effusion. No one discontinued due to the worsening of arthropathy and the joint manifestations all improved after treatment.Conclusion:Arthropathy may be induced after receiving VDZ, manifesting as elevated CRP, joint effusion, and bone marrow edema. After treatment with nonsteroidal anti-inflammatory drugs, glucocorticoids, immunosuppressants, or biological agents, most of the patients had a favorable prognosis.

Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders. Patients usually exhibit certain degree of social interaction impairment in accompany with impairment in language development as well as repetitive behaviors or interests. In recent years, ASD-related variants, genes, functional pathways, and expression patterns in the brain have been discovered, along with advance in sequencing techniques. This article reviews various aspects of genetic research in association with ASD.
Autism Spectrum Disorder/genetics* ; Cognition ; Genetic Research ; Humans ; Neurodevelopmental Disorders