Objective:To develop an expert consensus on safety management of inpatients with Alzheimer's disease (AD) (referred to as the " Consensus") and standardize safety management strategies for AD inpatients. Methods:The evidence on safety management of AD inpatients was searched, evaluated, and summarized, with a search period from database establishment to July 31, 2023. This study conducted methodological quality evaluation and evidence extraction on the included article to form a consensus draft. A total of 24 experts from 15 hospitals across the country were selected for two rounds of Delphi expert consultation to analyze, revise, and improve their opinions, forming the final draft of the Consensus. Results:The positive coefficients for both rounds of expert consultation were 100.00% (24/24). In the second round of consultation, the expert judgment basis coefficient was 0.925, familiarity level was 0.846, authority coefficient was 0.886, Kendall harmony coefficient was 0.044 ( P<0.01). The Consensus elaborated on five common safety problems (loss, falling, aspiration/choking, self-injury/other injury, and medication errors in AD inpatients) from three aspects (assessment, identification of risk factors, and nursing strategies) . Conclusions:The Consensus is scientific and practical to a certain extent, providing guidance and reference for the safety management practice of AD inpatients.

Objective To explore the effect of long non-coding RNA(long non-coding RNA,lncRNA)small RNA host gene 15(small nucleolar RNA host gene 15,SNHG 15)regulating microRNA 95-3p(miR-95-3p)on breast cancer cell proliferation and apoptosis.Methods Breast cancer cells were divided into control group,knockdown group,interference group and co-transfection group.Human breast cancer cell line MDA-MB-231 was cultured in vitro.Measure the relative expression levels of SNHG 15 mRNA and miR-95-3p mRNA;Methylthiazolyldiphenyl-tetrazolium bromide(MTT)was used to detect the proliferation ability of breast cancer cells;The apoptosis of breast cancer cells was detected by flow cytometry;The migration ability of breast cancer cells was detected by scratch test;Transwell invasion test was used to measure the number of breast cancer cells invaded;Western blot was used to determine the relative expression levels of caspase-3,B-cell lymphoma-2(Bcl-2),and Bcl-2 associated X protein(Bax).Results Compared with control group,the relative expression level of SNHG 15 mRNA and miR-95-3p mRNA,proliferation ability,proliferation rate,migration ability,number of invasion,Bcl-2 protein expression were decreased,but the apoptosis status,apoptosis rate,caspase-3 and Bax expression were increased in knockdown group(P＜0.05).Compared with knockdown group and interference group,the relative expression level of SNHG 15 mRNA and miR-95-3p mRNA,proliferation capacity,proliferation rate,migration capacity,number of invasion,Bcl-2 protein expression were increased,but apoptosis status,apoptosis rate,caspase-3 and Bax expression were decreased in co-transfection group(P＜0.05).Compared with interference group,the relative expression level of SNHG 15 mRNA and miR-95-3p mRNA,proliferation ability,proliferation rate,migration ability,number of invasion,Bcl-2 protein expression were increased,but apoptosis status,apoptosis rate,caspase-3 and Bax expression were decreased in co-transfection group(P＜0.05).Conclusion lncRNA SNHG 15 can affect the proliferation and apoptosis of breast cancer cells by regulating miR-95-3p expression,and is positively associated with the occurrence and development of breast cancer cells.