Objective:To observe the effect of intermittent theta burst transcranial magnetic stimulation (iTBS) on the language use, daily communication, and serum brain-derived neurotrophic factor (BDNF) levels of stroke survivors with motor aphasia (PSMA).Methods:A total of 60 PSMA patients were recruited and randomly divided into a control group and a treatment group, each of 30. Both groups received conventional speech training, while the treatment group additionally received daily 10-minute iTBS stimulation over the left dorsolateral prefrontal cortex, five days per week, for two weeks. Before and after the treatment, language function and daily communication were assessed using the Chinese Rehabilitation Research Center Standard Aphasia Examination (CRRCAE) and the Communication Activities of Daily Living (CADL) scale. Serum BDNF levels were measured using enzyme-linked immunosorbent assay.Results:After treatment, the CRRCAE and CADL scores in the treatment group were significantly higher than among the control group. The post-treatment serum BDNF levels in the treatment and control groups were (27.03±6.91)ng/ml and (22.20±5.89)ng/ml, respectively, both significantly higher than their pre-treatment levels. The average post-treatment serum BDNF level in the treatment group was significantly higher than the control group′s average.Conclusions:iTBS stimulation with speech training can better improve the language function and daily communication ability of stroke survivors with motor aphasia. The mechanism may be related to increased serum BDNF level.

Objective:To observe the effect of intermittent theta burst transcranial magnetic stimulation (iTBS) on the language use, daily communication, and serum brain-derived neurotrophic factor (BDNF) levels of stroke survivors with motor aphasia (PSMA).Methods:A total of 60 PSMA patients were recruited and randomly divided into a control group and a treatment group, each of 30. Both groups received conventional speech training, while the treatment group additionally received daily 10-minute iTBS stimulation over the left dorsolateral prefrontal cortex, five days per week, for two weeks. Before and after the treatment, language function and daily communication were assessed using the Chinese Rehabilitation Research Center Standard Aphasia Examination (CRRCAE) and the Communication Activities of Daily Living (CADL) scale. Serum BDNF levels were measured using enzyme-linked immunosorbent assay.Results:After treatment, the CRRCAE and CADL scores in the treatment group were significantly higher than among the control group. The post-treatment serum BDNF levels in the treatment and control groups were (27.03±6.91)ng/ml and (22.20±5.89)ng/ml, respectively, both significantly higher than their pre-treatment levels. The average post-treatment serum BDNF level in the treatment group was significantly higher than the control group′s average.Conclusions:iTBS stimulation with speech training can better improve the language function and daily communication ability of stroke survivors with motor aphasia. The mechanism may be related to increased serum BDNF level.

Objective:To study the clinical efficacy of acupuncture at Zusanli (ST 36)combined with Traditional Chinese Medicine (TCM) enema in the treatment of gastroparesis syndrome after gastrointestinal tumor operation.Methods:A total of 96 patients with gastroparesis syndrome after gastrointestinal tumor surgery in our hospital from June 2016 to May 2021, who met the inclusion criteria, were randomly divided into three groups by random drawing, with 32 in each group. The control group took mosapride citrate tablets orally, the TCM enema group added TCM enema on the basis of the control group, and the combined group added acupuncture Zusanli (ST 36)on the basis of the TCM enema group. All three groups were treated continuously for 4 weeks. The main syndromes were scored before and after treatment. The levels of serum gastrin (GAS), motilin (MTL) and somatostatin (SS) were detected by radioimmunoassay. The gastric electrophysiological parameters (waveform response area, waveform frequency and average amplitude) were detected by intelligent dual channel gastrointestinal electrograph, the adverse reactions during treatment were recorded, and the clinical efficacy was evaluated.Results:The total effective rate was 96.9% (31/32) in the combined group, 81.3% (26/32) in the TCM enema group and 68.8% (22/32) in the control group. There was significant difference among the three groups ( χ2=8.72, P=0.013). The scores of abdominal fullness and distention, fatigue, belching acid reflux, dry mouth and bitter mouth in the combined group were significantly lower than those in the TCM enema group and the control group ( F values were 16.39, 13.21, 11.28 and 10.23, respectively, P<0.001). After treatment, the levels of GAS [(140.62±15.19) ng/L vs. (128.79±14.34) ng/L, (115.98±12.40) ng/L, F=21.09], MTL [(268.66±28.21) ng/L vs. (245.89±25.24) ng/L, (230.78±22.43) ng/L, F=30.29] and SS [(70.58±8.17) ng/L vs. (65.50±7.76) ng/L, (59.73±7.05) ng/L, F=33.19] in the combined group were significantly higher than those in the TCM enema group and the control group ( P<0.01). The waveform response area [(172.62±17.14) μV/s vs. (158.56± 15.32) μV/s, (145.48±14.13) μV/s, F=20.24], waveform frequency [(3.86±0.61) cpm vs. (3.29±0.50) cpm, (3.01±0.63) cpm, F=13.17] and average amplitude [(86.51±8.98) μV vs. (75.70±7.93) μV, (68.65±7.46) μV, F=28.11] were significantly higher than those in TCM enema group and control group ( P<0.01). During the treatment period, the incidence of adverse reactions was 18.8% (6/32) in the combined group, 15.6% (5/32) in the TCM enema group and 12.5% (4/32) in the control group. There was no significant difference between the three groups ( χ2=0.47, P=0.789). Conclusion:Acupuncture at Zusanli (ST 36) combined with TCM enema can improve the TCM syndrome scores, gastrointestinal hormone level and gastric electrophysiological parameters of patients with gastroparesis syndrome after gastrointestinal tumor operation, improve the curative effect with safety.

Objective? To explore the effect of video education combined with Teach-back on the compliance of patients with rheumatoid arthritis(RA) to exercise at home and the condition of disease activity. Methods? By convenience sampling, 80 patients with RA who were hospitalized in the Rheumatology and Immunology Department of Sichuan Provincial People's Hospital from March to November 2018 were included in the study. By random number table, the patients were divided into the intervention group and control group, the control group was given routine discharge instruction and the patients were taught about the functional exercise orally; on the basis of that, the intervention group was given the video education combined with Teach-back and assisted to download videos, Family Exercise Compliance Scale and Disease Activity Score in 28 Joints(DAS28) were used to evaluate the patients' compliance in functional exercise at home and disease activity condition before intervention, 1 month and 3 months after intervention. Results? Finally, 73 cases(37 cases in the control group, 36 cases in the intervention group) in two groups completed the research plan. One and 3 months after intervention, the compliance with family functional exercise of the intervention group was better than the control group from the same period with statistical significance(P＜0.05); the scores of Tender Joint Coun(t TJC28), Swollen Joint Coun(t SJC28), Patient General Health(GH) of the intervention group were all lower than the control group from the same period with statistical significance (P＜0.05), however, the scores of Erythrocyte Sedimentation Rate(ESR) and DAS28 didn't demonstrate obvious intervention effects (P＞0.05). Conclusions? Video education combined with Teach-back can effectively improve the compliance of RA patients with home functional exercise, help to cultivate healthy behavior, and hence reduce the number of tender joint, swelling joints, reduce the degree of pain, improve the prognosis of patients.