Peripheral neuropathic pain(PNP)is a chronic pain condition caused by the primary damage or the dysfunction of the peripheral nervous system.The incidence of PNP is relatively high and increases with age,and PNP has significant impact on patients'quality of life.Common syndromes associated with PNP include postherpetic neuralgia,painful diabetic peripheral neuropathy,trigeminal neuralgia,and painful radiculopathy.Buyang Huanwu Decoction,originating from Wang Qingren's Yi Lin Gai Cuo(Corrections on the Errors of Medical Works during)the Qing Dynasty and mainly having the actions of replenishing qi and promoting blood circulation,removing stasis and unblocking collaterals,is primarily known as a representative formula for treating stroke due to qi deficiency and blood stasis.Nowadays,modern practitioners have extended its application in treating various multi-system diseases in internal medicine.This paper systematically reviewed clinical studies and pharmacological mechanisms of Buyang Huanwu Decoction in treating PNP over the past 20 years.The results indicated that the combination of herbs in Buyang Huanwu Decoction has multi-component,multi-target,and multi-pathway effects on repairing nerve damage,nourishing nerves,promoting nerve regeneration,and alleviating neuropathic pain.Buyang Huanwu Decoction shows significant efficacy in treating PNP syndromes caused by neuropathic damage resulting from various etiological factors.This article reviewed both clinical observation and basic research on Buyang Huanwu Decoction in treating PNP,aiming to provide references for the clinical treatment of PNP and to expand the clinical applications of Buyang Huanwu Decoction.

Objective: To examine the prevalence and associated factors of seeking casual male sexual partners among men who have sex with men (MSM) students in Guangzhou, and to provide a reference for health education and intervention. Methods: A cross-sectional study was conducted to recruit 189 MSM students aged 18 and 28 via voluntary counseling and testing (VCT) clinics, Lingnan partners and Zhitong charity from May 2017 to April 2018. An anonymous electronic questionnaire was administrated to collect information on sociodemographic and sexual behavior characteristics. Chi-square test and non-conditional Logistic regression analysis were performed to explore the associated factors of casual homosexual behavior among MSM students. Results: In the past 6 months, 63.49% (120/189) of them reported casual male partners, and the rate of consistent condom use was 61.67%(74/120). Multivariate Logistic regression analysis showed that participants who had multiple sex partners in the past 6 months were more likely to seek male casual partners(aOR=9.13, 95%CI=4.27-19.53). Individuals who used recreational drugs before sex were at a higher risk of having casual sex behaviors(aOR=3.06, 95%CI=1.08-8.62). MSM students who had steady homosexual partners had a lower risk to seek casual sex(aOR=0.43, 95%CI=0.19-0.98). Conclusion The proportion of seeking casual male sexual partners among MSM students in Guangzhou was relatively high. The publicity and education should be strengthened among those who had multiple sex partners, with no steady homosexual partners and used recreational drugs before sex, to reduce the casual sex behaviors.