BACKGROUND: Lung adenocarcinoma is an important pathohistologic subtype of non-small cell lung cancer (NSCLC). Invasive non-mucinous pulmonary adenocarcinomas (INMA) tend to have a poor prognosis due to their significant heterogeneity and diverse histologic components. Establishing a histologic grading system for INMA is crucial for evaluating its malignancy. In 2021, the International Association for the Study of Lung Cancer (IASLC) proposed that a new histological grading system could better stratify the prognosis of INMA patients. The aim of this study was to establish a visualized nomogram model to predict INMA IASLC grading preoperatively by means of dual-energy computed tomography (DECT), fractal dimension (FD), clinical features and conventional CT parameters. METHODS: A total of 112 patients with INMA who underwent preoperative DECT were retrospectively enrolled from March 2021 to January 2025. Patients were categorized into low-intermediate grade and high grade groups based on IASLC grading. The clinical characteristics and conventional CT parameters, including baseline features, biochemical markers, and serum tumor markers, were collected. DECT-derived parameters, including iodine concentration (IC), effective atomic number (eff-Z), and normalized IC (NIC), were collected and determined as NIC ratio (NICr) and fractal dimension (FD). Univariate analysis was employed to compare differences in conventional characteristics and DECT parameters between the two groups. Variables demonstrating statistical significance were subsequently incorporated into a multivariate Logistic regression analysis. A nomogram model integrating clinical data, conventional CT parameters, and DECT parameters was developed to identify independent predictors for IASLC grading of INMA. The discriminatory performance of the model was evaluated using receiver operating characteristic (ROC) curve analysis. RESULTS: Multivariate analysis identified smoking history [odds ratio (OR)=2.848, P=0.041], lobulation sign (OR=2.163, P=0.004), air bronchogram (OR=7.833, P=0.005), eff-Z in arterial phase (OR=4.266, P<0.001), and IC in arterial phase (OR=1.290, P=0.012) as independent and significant predictors for IASLC grading of INMA. The nomogram model constructed based on these indicators demonstrated optimal predictive performance, achieving an area under the curve (AUC) of 0.804 (95%CI: 0.725-0.883), with specificity and sensitivity of 85.3% and 65.7%, respectively. CONCLUSIONS The nomogram model based on clinical features, imaging features and spectral CT parameters have a large potential for application in the preoperative noninvasive assessment of INMA IASLC grading.
Humans ; Nomograms ; Female ; Male ; Middle Aged ; Tomography, X-Ray Computed/methods* ; Lung Neoplasms/pathology* ; Aged ; Retrospective Studies ; Adenocarcinoma of Lung/pathology* ; Neoplasm Grading ; Adult

Objective:To analyze the research trends and hotspots of anti-Müllerian hormones (AMH) from 2006 to 2020, and to provide reference for future research in related fields.Methods:Based on the PubMed database, the literatures related to AMH collected from January 1st, 2006 to December 31st, 2020 were retrieved, and the bibliometric method was used to analyze the relationship between each stage and AMH with every 5 years as the time node. The publication trends, high-frequency main MeSH/subheadings co-occurrence and research hotspots related to AMH were discussed and forecasted.Results:A total of 4 276 related literatures were retrieved in this paper, and the total number of published papers showed an increasing trend. Relevant research hotspots were gradually increasing. The core research from 2005 to 2010 was the biomarker effect of AMH; from 2011 to 2015 and 2016 to 2020, the core research hotspots were all AMH and polycystic ovary syndrome.Conclusion:While the research hotspots related to AMH have been continuously expanded and enriched, there are also certain changes and alternations, and some emerging hotspots still have the value and significance of further research. AMH type Ⅱ receptor and fertility preservation may become an emerging hotspot in this field in the future.

Objective:To analyze the research trends and hotspots of anti-Müllerian hormones (AMH) from 2006 to 2020, and to provide reference for future research in related fields.Methods:Based on the PubMed database, the literatures related to AMH collected from January 1st, 2006 to December 31st, 2020 were retrieved, and the bibliometric method was used to analyze the relationship between each stage and AMH with every 5 years as the time node. The publication trends, high-frequency main MeSH/subheadings co-occurrence and research hotspots related to AMH were discussed and forecasted.Results:A total of 4 276 related literatures were retrieved in this paper, and the total number of published papers showed an increasing trend. Relevant research hotspots were gradually increasing. The core research from 2005 to 2010 was the biomarker effect of AMH; from 2011 to 2015 and 2016 to 2020, the core research hotspots were all AMH and polycystic ovary syndrome.Conclusion:While the research hotspots related to AMH have been continuously expanded and enriched, there are also certain changes and alternations, and some emerging hotspots still have the value and significance of further research. AMH type Ⅱ receptor and fertility preservation may become an emerging hotspot in this field in the future.

Objective:To analyze the psychological stress of infertile patients after COVID-19 epidemic and its related factors by Chinese version of the perceived stress scale (CPSS).Method:The basic information, reproductive history, impact of the epidemic, psychological status of patients undergoing assisted reproductive technology at the General Hospital of Northern Theater Command from March 29, 2021 to April 29, 2021 were collected by questionnaire. According to CPSS, group comparison and correlation analysis were used to explore factors related to patients' psychological stress.Results:A total of 251 valid questionnaires were received. The average CPSS score of the patients was 22.43±7.07. During the epidemic, about 33.86% (85/251) of the infertility patients postponed the fertilization plan; there were significant differences in the psychological stress among patients of different genders, occupations, and postponed fertilization plans at different stages of fertilization ( P=0.001, P=0.005, P=0.002). There was no significant difference in CPSS score between infertile patients who delayed treatment or not ( P>0.05). Correlation analysis showed that the perceived stress of patients was negatively correlated with their age, income, and delay duration ( r=-0.192, P=0.002; r=-0.323, P=0.001; r=-0.282, P=0.009). Among all patients who delayed treatment, patients with higher CPSS score would restart treatment sooner; most of the infertile patients knew little about the vaccine. Conclusion:The COVID-19 epidemic has caused a certain impact on the psychological pressure of infertile couples who accepted treatment in our hospital. The psychological care for infertile patients is particularly important. In the future, in order to dispel the doubts of infertile patients about the vaccine, we should pay attention to the correct scientific promotion of the COVID-19 vaccine during the treatment process.

Objective:To analyze the psychological stress of infertile patients after COVID-19 epidemic and its related factors by Chinese version of the perceived stress scale (CPSS).Method:The basic information, reproductive history, impact of the epidemic, psychological status of patients undergoing assisted reproductive technology at the General Hospital of Northern Theater Command from March 29, 2021 to April 29, 2021 were collected by questionnaire. According to CPSS, group comparison and correlation analysis were used to explore factors related to patients' psychological stress.Results:A total of 251 valid questionnaires were received. The average CPSS score of the patients was 22.43±7.07. During the epidemic, about 33.86% (85/251) of the infertility patients postponed the fertilization plan; there were significant differences in the psychological stress among patients of different genders, occupations, and postponed fertilization plans at different stages of fertilization ( P=0.001, P=0.005, P=0.002). There was no significant difference in CPSS score between infertile patients who delayed treatment or not ( P>0.05). Correlation analysis showed that the perceived stress of patients was negatively correlated with their age, income, and delay duration ( r=-0.192, P=0.002; r=-0.323, P=0.001; r=-0.282, P=0.009). Among all patients who delayed treatment, patients with higher CPSS score would restart treatment sooner; most of the infertile patients knew little about the vaccine. Conclusion:The COVID-19 epidemic has caused a certain impact on the psychological pressure of infertile couples who accepted treatment in our hospital. The psychological care for infertile patients is particularly important. In the future, in order to dispel the doubts of infertile patients about the vaccine, we should pay attention to the correct scientific promotion of the COVID-19 vaccine during the treatment process.