ObjectiveTo investigate the supply satisfaction with community-embedded elderly care services in Nanchang city， which can assist in optimizing its supply system of elderly care services and build a policy system for high-quality development of community-embedded elderly care services for reference. MethodsA total of 15 indicators from three dimensions： resource embeddedness， functional embeddedness， and operational-mode embeddedness， were selected to design the Elderly Care Service Supply Satisfaction Scale. A simple random sampling method was used to survey elderly residents in 25 community-embedded elderly care institutions in Nanchang city， and the binary logistic regression model and structural equation model were used for analysis. ResultsFirst， resource embeddedness and operational-mode embeddedness had a significantly positive impact on supply satisfaction. Second， the weight of resource embeddedness， functional embeddedness， and operational-mode embeddedness on supply satisfaction decreased gradually. Third， the “number of service personnel” and “adequacy of service types” in the resource embeddedness dimension， the “entertainment services” and “medical services” in the functional embeddedness dimension， and the “charging standard” and “service response degree” in the operational-mode embeddedness dimension had a greater impact on supply satisfaction in their corresponding dimensions. ConclusionTo develop community-embedded elderly care， it is essential to strengthen the construction of the team of elderly care professionals， enrich the supply content of elderly care services， and increase the development support with the help of resource embeddedness； establish a unified charging system for elderly care， improve the responsiveness of elderly care services， and enhance the development internal driving force based on operational-mode embeddedness； improve the level of integrated medical and elderly care， emphasize the return of the family as the main body， and perfect the development system by using functional embeddedness as a link.

PURPOSE: To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated. METHODS: Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3+/-4.6 months. Pharmacokinetic studies of CsA were done twice at beginning and closing of 12 months' CsA therapy. RESULTS: The steady state CsA pharmacokinetic parameters of 34 patients were as follows; Tmax:1.64+/-0.84 hr, Cmax:788+/-354 ng/dL, C12:58.7+/-33.2 ng/mL, Cavg:246+/-96 ng/mL, AUC:2,949+/-1,156 ng hr/mL, Vd:4.03+/-0.45 L/kg, CL:9.69+/-2.27 L/hr, T1/2:5.31+/-2.37 hr. C2 was the best to predict the CsA AUC(R=0.896, P<0.001). Body surface area based dosage(mg/m2/d) correlates best with AUC. Intra-individual CsA pharmacokinetic changes were not found after 12 months' therapy. Anti-proteinuric effect of CsA was considerable; 88.9% of primary nephrotic syndrome and 62.5% of secondary glomerular diseases was responsive to CsA thearpy. There was no serious complication and CsA treatment was well tolerated by the pediatric patients. CONCLUSION: CsA therapy for difficult renal diseases with proteinuria was effective and safe. For better AUC prediction of CsA, body surface area based dosage(mg/m2/d) and C2 monitoring are recommended in children with renal diseases.
Area Under Curve ; Body Surface Area ; Child* ; Cyclosporine* ; Humans ; Nephrotic Syndrome ; Pharmacokinetics* ; Proteinuria