Objective:To explore the effect of early eschar dermabrasion combined with antimicrobial soft silicone foam dressing (hereinafter referred to as foam dressing) in treating the deep partial-thickness burn wounds in children.Methods:This study was a randomized controlled trial. From June 2021 to December 2022, 78 pediatric patients with deep partial-thickness burns who met the inclusion criteria were admitted to the Department of Burns in Guiyang Steel Plant Employees Hospital. According to the random number table, the pediatric patients were divided into two groups, with 38 cases left in combined treatment group (with 20 males and 18 females, aged 26.00 (16.75, 39.75) months) and 39 cases in foam dressing group (with 21 males and 18 females, aged 19.00 (14.00, 31.00) months) after the exclusion of one dropped-out child in follow-up. The pediatric patients in combined treatment group underwent eschar dermabrasion of the wound within 48 hours after injury, the wound was covered with foam dressing after operation, and the dressing was replaced once every 7 days; for the pediatric patients in foam dressing group, the wound was sterilized within 48 hours after injury and covered with foam dressing, and the dressing was replaced once every 2 to 3 days. After the wound healing, the children in both groups were routinely applied with silicone gel twice a day for 3 weeks before started wearing elastic sleeves for more than 18 hours a day, and continuously for over than 6 months. The degree of pain during dressing change was evaluated using the children's pain behavior inventory FLACC. The adverse reactions during the treatment period, number of dressing changes, and wound healing time were observed and recorded. Six months after wound healing, the Vancouver scar scale (VSS) was used to evaluate the condition of the wound scar.Results:When changing dressing, the FLACC score for pain of pediatric patients in combined treatment group was 3.5 (2.0, 5.0), which was significantly lower than 6.0 (5.0, 8.0) in foam dressing group ( Z=-5.40, P<0.05). During the treatment period, no adverse reactions such as wound edema, fluid accumulation, or peripheral skin rash allergies occurred in any pediatric patient in both groups. The number of dressing changes of pediatric patients in combined treatment group was 3 (3, 4) times, which was significantly less than 8 (7, 10) times in foam dressing group ( Z=-7.58, P<0.05). The wound healing time of pediatric patients in combined treatment group was (19±5) days, which was significantly shorter than (25±6) days in foam dressing group ( t=-4.48, P<0.05). Six months after wound healing, the VSS score for scar of pediatric patients in combined treatment group was 5 (2, 8), which was significantly lower than 7 (5, 10) in foam dressing group ( Z=-3.05, P<0.05). Conclusions:Compared with using foam dressings alone, early eschar dermabrasion combined with foam dressings can reduce the number of dressing changes, alleviate the pain during dressing changes, and shorten the wound healing time in treating children with deep partial-thickness burns, and effectively alleviate scar hyperplasia by combining with anti-scar treatment post burns.

ObjectiveTo compare the therapeutic effec between sustained low-efficiency dialysis (SLED) and continuous blood purification (CBP) in critically ill patients.MethodsAccording to the treatment ways,96 critically ill patients were divided into SLED group and CBP group.A comparison was made on the biochemical indicators,in-hospital duration,hemodynamic parameters,acute physiology and chronic health evaluation (APACHE-Ⅱ ),the survival and the mortality rates.ResultsAfter treatment,the levels of serum creatine kinase isozyme MB (CK-MB),creatine kinase (CK),creatinine (Cr),glutamic-oxalacetic transaminase (AST),glutamate-pyruvate transaminase (ALT),APACHE Ⅱ score on the 1st,2nd and 7th day were lower than those prior to the treatment in both groups ( P ＜0.05).There were no statistical differences in in-hospital duration, biochemical indicators, APACHEⅡscore,hemodynamic parameters,the survival rate and the mortality rate between the two groups (P ＞ 0.05 ).ConclusionsSLED has similar hemodynamic stability with CBP,and the two methods have similar treatment effects in critically ill patients.However,SLED can be relatively economical and convenient for critically ill patients in clinical.

Objective To explore the anti-epileptic effect and mechanism of Shenpu Decoction.MethodsThe pilocarpine-induced epilepsy model was adopted. 50 rats were randomly divided into the Shenpu Decoction control group (n=8), blank control group (n=8), Shenpu Decoction plus pilocarpine group (n=8) and pilocarpine-induced epilepsy model group (n=26), the last group was re-divided into the Shenpu Decoction treatment group and model control group. The incidence of convulsion and the content of free amino acids in brain tissues were observed.ResultsThe incidence of convulsion was 0 in the Shenpu Decoction plus pilocarpine group and 88.5% in the pilocarpine-induced epilepsy model group, there was a significant difference between two groups ( P<0.05). The content of glutamic acid in brain tissue of the Shenpu Decoction plus pilocarpine group and pilocarpine-induced epilepsy model group higher than that of the blank control group ( P<0.05～0.01). The content of gamma-aminobutyric acid in brain tissue of the Shenpu Decoction plus pilocarpine group and Shenpu Decoction treatment group was higher than that of the model control group ( P<0.05).ConclusionShenpu Decoction can effectively prevent and terminate the episodes of convulsion.

Objective To study the clinical effect of herbs of replenishing qi, nourishing yin and promoting blood combined with western medicine on symptoms and hemorrheology indexes of aged diabetic mellitus (DM). Methods Sixty cases with DM-2 were randomly divided into two groups. The treatment group was given herbs combined with western medicine and the control group was given western medicine treatment only. The treatment course was 1 month. The clinical symptoms, blood glucose and hemorrheology indexes were observed in both groups. Results There were 11 marked effective cases, 15 effective cases and 4 ineffective cases in treatment group, while 2, 12 and 16 cases in control group. The total effective rate was 86.7% in treatment group and 46.7% in control group. There was a significant difference between the two groups. The whole blood viscosity, platelet aggregation, D-dimer and fingernail microcirculation were significantly improved in the treatment group. Conclusion The herbs of replenishing qi, nourishing yin and promoting blood combined with western medicine can improve the clinical symptoms and hemorrheology of aged DM.

Objective: To investigate the effects of traditional Chinese medicine Baoyuanhuoxue Granula on the state of senile type Ⅱdiabetes before thrombus.Methods: 60 cases of selected senile type Ⅱdiabetes patients were divided into two groups,trial group(treatment with routine western medicine added Baoyuanhuoxue Granula;30 cases) and control group(treatment with simple western medicine; 30 cases).After two months,the changes of expression rate of blood viscosity, nail fold microcirculation and platelet aggregation,D-D,CD-62p and PAC-1 of patients in two groups before and after treatment were observed.Results: Baoyuanhuoxue Granula can reduce the expression rate of blood viscosity,platelet aggregation,D-D,CD-62p and PAC-1 obviously,and can improve nail fold microcirculation.Conclusion: Baoyuanhuoxue Granula can improve the state of senile type Ⅱdiabetes before thrombus.

ObjectiveTo observe the improve effect of Yiqihuoxue Chinese materia medica for the ethology of mouse with diabetes mellitus encephalopathy induced by streptozotocin (STZ).MethodsCreating mouse model using 1% STZ intraperitoneal injection. 50 mouses were randomly divided into the normal control group, model control group, large dosis Chinese materia medica group, middle dosis Chinese materia medica group and small dosis Chinese materia medica group. Mouses'behaviors of evading dark reaction and Morris water maze in different groups were tested.ResultsYiqihuoxue Chinese materia medica had not the fuction of lower blood suga to the mouse with diabetes mellitus encephalopathy induced by STZ. But Yiqihuoxue chinese materia medica could improve the ethology show and mental status of mouse with diabetes mellitus encephalopathy induced by STZ obviosly, decrease the lightning stroke frequency when the diabetes mellitus encephalopathy mouses entered the dark chamber, extend the latency period, shorten the diabetes mellitus encephalopathy mouses swimming out time and distance, improve the study and memory ability.ConclusionYiqihuoxue Chinese materia medica had the improve effect for the ethology of mouse with diabetes mellitus encephalopathy induced by STZ.