Objective To compare the intestinal injury induced by different intensities of waveshock in rats exposed to extremely cold environment and to preliminarily explore the characteristics of the injury.Methods Sixty healthy male SD rats(2 months old,weighing 200～250 g)were randomly divided into 6 groups(n=10):blank control group,low-temperature control group,5.0 MPa shock control group,and low-temperature+4.0,4.5 and 5.0 MPa shock groups.The rats in the experimental groups were pre-treated in a-10℃low-temperature environment for 30 min and then subjected to intestinal injury by using BST-I biological shock tube with different driving pressures.At 3,8,and 24 h after injury,the serum levels of IL-6,TNF-α,intestinal fatty acid binding protein(I-FABP),and diamine oxidase(DAO)were detected,and the survival of rats within 24 h was recorded.At 24 h after injury,the rats were anesthetized and dissected,the characteristics of intestinal injury were observed,and pathological examination was performed.The differences of intestinal injury were compared among the 6 groups to explore the characteristics of intestinal injuries after different intensities of shockwave in rats after exposure to extremely cold environment.Results Compared with the blank control group,the other 5 groups exhibited different severities of intestinal injury,and the rats in the low-temperature+different shock groups were more prone to intestinal edema and trauma.The mortality rate was significantly increased in the low-temperature+5.0 MPa shock group(P<0.05).Pathological and serological studies found that dual effects of very cold environment and blast injury resulted in intestinal mucosal hemorrhage,edema,and disintegration of lamina propria in the experimental rats.The indicators of intestinal mucosal injury and intestinal inflammatory factors were also significantly increased when compared with the blank control group,and significant differences were among the groups with increment of shock intensity(P<0.05).Conclusion Exposure to very cold environment combined with abdominal blast injury increases mortality rate in rats,manifested by elevated serological indicators and intestinal inflammatory factors,as well as varying severities of intestinal wall edema and submucosal bleeding.Furthermore,the severity of the injury is positively related to the impact intensity,with worsened as the impact intensity increasing.

Objective To observe the clinical efficacy of acupotomy release therapy under the theory of sinew channels in the treatment of femoral head necrosis.Methods A total of 82 patients diagnosed with femoral head necrosis who underwent hip-preserving treatment at Beijing Hepingli Hospital from May 2020 to May 2023 were selected as the study subjects.The patients were randomly divided into an observation group and a control group using a random number table,with 41 patients in each group.The control group received hip joint rehabilitation training combined with sinew channel massage therapy,while the observation group received acupotomy release therapy under the theory of sinew channels in addition to the treatment given to the control group.for 6 months of treatment.Changes in the Visual Analogue Scale(VAS)scores of pain,hip joint range of motion,and Harris scores were observed before and after treatment.Additionally,serum levels of 5-hydroxytryptamine(5-HT),substance P(SP),calcitonin gene-related peptide(CGRP),and neuropeptide Y(NPY)were compared between the two groups before and after treatment.Results(1)After treatment,the VAS scores of both groups were significantly improved(P＜0.05),and the observation group showed significantly better improvement in VAS scores compared to the control group,with a statistically significant difference(P＜0.05).(2)After treatment,the hip joint range of motion improved significantly in both groups(P＜0.05),and the observation group showed significantly better improvement in hip joint range of motion compared to the control group,with a statistically significant difference(P＜0.05).(3)After treatment,the excellent and good rate of hip joint function in the observation group was 95.12%(39/41),while it was 78.05%(32/41)in the control group.The observation group had a significantly higher excellent and good rate of hip joint function compared to the control group,with a statistically significant difference(P＜0.05).(4)After treatment,the levels of 5-HT,SP,CGRP,and NPY improved significantly in both groups(P＜0.05),and the observation group showed significantly better improvement in these levels compared to the control group,with a statistically significant difference(P＜0.05).Conclusion Acupotomy release therapy under the theory of sinew channels in the treatment of femoral head necrosis can significantly alleviate pain symptoms and improve hip joint function in patients.Its analgesic mechanism may be related to the regulation of neurotransmitter levels and the restoration of their balance.

Objective To discuss the effect of interleukin-17A(IL-17A)and transforming growth factor-β1(TGF-β1)on the benign tracheal stenosis after tracheal injury in experimental dogs.Methods The trachea stenosis model of healthy Beagle dogs was established by burning the middle part of trachea with electric snare under bronchoscopy guidance.A total of 21 dogs were divided into normal group(n=3,receiving normal feeding),molding group(n=12,after airway modeling every 3 dogs were sacrificed each week for 4 weeks),IL-17A suppression group(n=3,receiving Secukinumab after airway modeling),and IL-17A inhibitor+TGF-β1 inhibitor group(n=3,receiving Secukinumab and SB43154 after airway modeling).Bronchoscopy and CT scan were performed once a week,and the stenosis degree was calculated.RT-qPCR,immunohistochemistry,and HE staining of the obtained tracheal tissues were performed.Results Within 1-4 weeks after molding,in module-making dogs the degree of stenosis of the injured trachea gradually increased,and the expressions of ECM-related proteins,TGF-β1 and IL-17A were up-regulated.After treatment with IL-17A inhibitors,the inflammatory infiltration and granulation tissue hyperplasia were reduced and the early tracheal stenosis was improved(P＜0.05).The combination use of IL-17A inhibitor and TGF-β1 inhibitor had a better remission effect(P＜0.05).Conclusion IL-17A and TGF-β1 may synergistically affect the formation of tracheal stenosis.

Sarcopenia, characterized by reduced muscle mass, decreased strength, and impaired function, can lead to adverse outcomes, such as frailty, falls, fractures and disability, and subsequently lead to decreased quality of life, increased risk of complications and mortality and elevated healthcare costs. With the accelerating process of global aging, the prevalence of sarcopenia has significantly risen, posing a major public health threat and socioeconomic burden to populations worldwide. To more effectively implement medical nutrition management and exercise intervention for patients with sarcopenia, the Chinese Clinical Nutritionist Center of Chinese Medical Doctor Association and the Nutrition Oncology Branch and Geriatric Nutrition Branch of the Chinese Nutrition Society, in collaboration with the Nutrition and Food Safety Branch of Chinese Geriatrics Society, have developed the Expert Consensus on Medical Nutrition Management and Exercise Intervention for Sarcopenia (2024) based on the latest research evidence, clinical practice experiences and clinical nutrition guidelines. This consensus serves as a reference for clinical diagnosis and treatment of sarcopenia. The consensus emphasizes that the diagnosis and treatment of sarcopenia should focus on elderly population and also encompass patients with related chronic diseases including diabetes, inflammatory bowel disease, cancer, cognitive dysfunction and Parkinson's disease. Multi-modal lifestyle interventions centered on nutrition and exercise remain the preferred strategy for the prevention and treatment of sarcopenia.

Vitamin-mineral supplements have clear health benefits in specific populations, but the needs for these nutrients vary among different physiological stages: Periconceptional folic acid supplementation reduces the risk of fetal neural tube defects; iron supplementation prevents iron-deficiency anemia; combined use of calcium and vitamin D helps maintain bone density in middle-aged and older adults; and multivitamin-mineral supplementation may delay age-related cognitive decline in elderly adults. For patients with chronic diseases, regular multivitamin-mineral intake may reduce the risk of respiratory infections and may even alleviate symptoms in specific subpopulations. Studies in Linxian have suggested lower mortality from esophageal cancer after multivitamin-mineral supplementation, although β-carotene may increase lung cancer risk among smokers. A combination of vitamin C and E, zinc, and β-carotene may slow the progression of age-related macular degeneration. Due to the synergistic effects among nutrients, combination formulations may be more advantageous. However, the use of fat-soluble vitamins must be lower than the tolerable upper intake levels to avoid accumulation and toxicity. For individuals at high risk of nutrient deficiency, the vitamin and mineral levels should be tested before supplementation, along with regular monitoring to facilitate dose adjustment. Liver and kidney function should be monitored in patients with chronic diseases after starting supplementation. In summary, vitamin and mineral supplements can improve health outcomes in specific populations. However, the use of these nutrients should be evidence-based and individualized, and vitamin-mineral supplements are not substitutes for medications or a balanced diet.

The dramatically rising incidence of chronic diseases decreases quality of life, increases complications and all-cause mortality, and raises medical costs. Scientifically sound nutritional therapy is currently the most affordable and safest basic treatment for patients with chronic diseases, as it can help improve nutritional status, clinical outcomes, quality of life, and survival rates for patients with chronic diseases. The Nutrition Oncology Branch of Chinese Nutrition Society has developed the Expert consensus on nutritional therapy for patients with common chronic diseases (2025) based on the latest research evidence, clinical practice, and clinical nutrition guidelines to inform the nutritional diagnosis and treatment of chronic disease.

Cross-border teaching provides new opportunities for college students to gain diverse insights amid the globalization and internationalized education, In July 2024, guided by the Chinese Association for Science and Technology, the Chinese Nutrition Society and the Hong Kong Nutrition Association collaborated to host a three-week clinical nutrition internship at Peking Union Medical College Hospital for five college students from Hong Kong SAR, China. This program included participating in outpatient rounds, attending in inpatient nutrition management, and attending lectures, aiming to enhance students' professional skills and clinical experience. Cultural exchange and value-based education also enriched students' social responsibility and cultural understanding. The Hong Kong students also brought diverse cultural backgrounds and inputs, enabling multidimensional communication during the training. Post-internship feedback survey showed that the students found the inernship valuable for their career development and hoped for more learning opportunities. This cross-border high-quality internship program fostered skill enhancement, cultural exchange between young students in Beijing and Hong Kong and contributed to advancement of clinical nutrition.

Objective:To investigate the current situation and correlation between mental health and stressors of new professional master's degree graduates in clinical medicine, and to provide empirical support for improving student mental health.Methods:An online questionnaire survey was conducted among 3 587 fresh graduate students with master's degree in clinical medicine from 65 training institutions in China. SPSS 26.0 was used to compare and analyze the measurement data. Descriptive statistics were used to analyze the mental health using Symptom Checklist-90 (SCL-90) and the current status of stressors. The influence factors and correlation between mental health and stressors were analyzed by means of differentiation analysis and correlation analysis.Results:The SCL-90 overall mean score as well as the scores of obsessive-compulsive symptoms, interpersonal sensitivity, depression, terror, anxious, psychoticism, and hostility of new professional master's degree graduates in clinical medicine were all higher than the national norm ( P<0.05). Among the participants, 58.21% (2 088/3 587) exhibited varying degrees of symptoms listed in the SCL-90. Students from families with low per capita income and low parental education level have more prominent psychological problems. The top three stressors perceived were job seeking, research tasks, and self-ability. Students with positive SCL-90 symptoms reported significantly higher perceived stress in all three stressor dimensions compared to their symptom-negative counterparts ( P<0.001), indicating a significant correlation between mental health status and stressors. Conclusions:The mental health status of new professional master's degree graduates in clinical medicine is concerning and warrants focused attention from educational authorities, academic institutions, and families.

Sarcopenia, characterized by reduced muscle mass, decreased strength, and impaired function, can lead to adverse outcomes, such as frailty, falls, fractures and disability, and subsequently lead to decreased quality of life, increased risk of complications and mortality and elevated healthcare costs. With the accelerating process of global aging, the prevalence of sarcopenia has significantly risen, posing a major public health threat and socioeconomic burden to populations worldwide. To more effectively implement medical nutrition management and exercise intervention for patients with sarcopenia, the Chinese Clinical Nutritionist Center of Chinese Medical Doctor Association and the Nutrition Oncology Branch and Geriatric Nutrition Branch of the Chinese Nutrition Society, in collaboration with the Nutrition and Food Safety Branch of Chinese Geriatrics Society, have developed the Expert Consensus on Medical Nutrition Management and Exercise Intervention for Sarcopenia (2024) based on the latest research evidence, clinical practice experiences and clinical nutrition guidelines. This consensus serves as a reference for clinical diagnosis and treatment of sarcopenia. The consensus emphasizes that the diagnosis and treatment of sarcopenia should focus on elderly population and also encompass patients with related chronic diseases including diabetes, inflammatory bowel disease, cancer, cognitive dysfunction and Parkinson's disease. Multi-modal lifestyle interventions centered on nutrition and exercise remain the preferred strategy for the prevention and treatment of sarcopenia.

Vitamin-mineral supplements have clear health benefits in specific populations, but the needs for these nutrients vary among different physiological stages: Periconceptional folic acid supplementation reduces the risk of fetal neural tube defects; iron supplementation prevents iron-deficiency anemia; combined use of calcium and vitamin D helps maintain bone density in middle-aged and older adults; and multivitamin-mineral supplementation may delay age-related cognitive decline in elderly adults. For patients with chronic diseases, regular multivitamin-mineral intake may reduce the risk of respiratory infections and may even alleviate symptoms in specific subpopulations. Studies in Linxian have suggested lower mortality from esophageal cancer after multivitamin-mineral supplementation, although β-carotene may increase lung cancer risk among smokers. A combination of vitamin C and E, zinc, and β-carotene may slow the progression of age-related macular degeneration. Due to the synergistic effects among nutrients, combination formulations may be more advantageous. However, the use of fat-soluble vitamins must be lower than the tolerable upper intake levels to avoid accumulation and toxicity. For individuals at high risk of nutrient deficiency, the vitamin and mineral levels should be tested before supplementation, along with regular monitoring to facilitate dose adjustment. Liver and kidney function should be monitored in patients with chronic diseases after starting supplementation. In summary, vitamin and mineral supplements can improve health outcomes in specific populations. However, the use of these nutrients should be evidence-based and individualized, and vitamin-mineral supplements are not substitutes for medications or a balanced diet.