Objective:To explore the main points of differential diagnosis between pelvic tuberculosis and ovarian epithelial cancer.Methods:A retrospective case series study was conducted. The clinical data of 336 patients with pelvic mass admitted to Gansu Provincial Maternal and Child-Care Hospital from January 2012 to July 2020 were collected, and they were divided into pelvic tuberculosis group (112 cases) and ovarian epithelial cancer group (224 cases) according to postoperative pathological examination results. The clinical symptoms, tumor markers, gynecologic color ultrasound and imaging examination results between the 2 groups were compared.Results:Abdominal distension [81.25% (91/112) vs. 82.14% (184/224)], anorexia [35.71% (40/112) vs. 32.15% (72/224)] and pelvic mass [42.86% (48/112) vs. 43.30% (97/224)] were the first symptoms in both pelvic tuberculosis group and ovarian epithelial cancer group, and the differences were statistically significant (all P > 0.05). The levels of carbohydrate antigen 125 (CA125), human epididymal protein 4 (HE4) and carbohydrate antigen 724 (CA724) in pelvic tuberculosis group were lower than those in ovarian epithelial cancer group, and the differences were statistically significant (all P < 0.05). The receiver operating characteristic curve showed that HE4 had the highest area under the curve (0.943), its optimal cut-off value was 92.54 pmol/L and the detection rate reached 85.7%. HE4 had the highest sensitivity in the diagnosis of the ovarian cancer. The proportion of cystic mass in pelvic tuberculosis group was higher compared with that in ovarian epithelial cancer group, and the difference was statistically significant [42.9% (48/112) vs. 12.5% (28/224), χ2 = 39.31, P = 0.001]. The incidence of retroperitoneal lymph node enlargement in ovarian epithelial cancer group was higher than that in pelvic tuberculosis group, and the difference was statistically significant [55.4% (124/224) vs. 0, P = 0.001]. Conclusions:The differential diagnosis between pelvic tuberculosis and ovarian epithelial cancer mainly depends on tumor markers, ultrasound, imaging findings. The levels of CA125 and HE4 in ovarian epithelial cancer group are higher than those in pelvic tuberculosis group, and the combined examination of CA125 and HE4 could be more conducive to differential diagnosis between pelvic tuberculosis and ovarian epithelial cancer.

Objective:To analyze the effect of hyperbaric oxygen (HBO) assisted treatment on fetal growth restriction (FGR).Methods:A total of 110 pregnant women with FGR admitted in Gansu Provincial Maternity and Child-care Hospital from June 2018 to June 2019 were selected as research objects. They were randomly divided into observation group and control group in a ratio of 1∶1, with 55 cases in each group. The control group was treated with low molecular heparin combined with aspirin, and the observation group was treated with HBO on the basis of the treatment of the control group for 6 weeks. The fetal growth was examined by color Doppler ultrasound. The clinical effect and fetal hemodynamic parameters before and after treatment were compared. The maternal and infant outcomes such as complications of pregnancy and neonatal conditions were statistically analyzed. The coagulation functions of pregnant women before and after treatment were also analyzed.Results:The effective rate of the observation group (83.64%) was significantly higher than that of the control group (63.64%) with statistical difference ( χ2=5.666, P=0.017). After treatment, the high systolic blood flow/late diastolic blood flow (S/D), resistance index (RI), and pulse index (PI) of the two groups were all remarkably decreased ( P<0.01), and those of the observation group were lower than those of the control group ( P<0.05) before and after treatment. There was no statistical difference in the comparisons of neonatal complications and pregnancy complications after treatment between the two groups ( P>0.05). The coagulation function index of both two groups after treatment were all improved than those before treatment with statistically significant difference ( P<0.05), but there was no statistically significant difference between the coagulation function index of the observation group and that of the control group after treatment( P>0.05). Conclusion:HBO combined with aspirin and low molecular heparin in the treatment of FGR can significantly improve the fetal hemodynamic parameters, and therefore improve the clinical efficacy.

Objective:To analyze the effect of hyperbaric oxygen (HBO) assisted treatment on fetal growth restriction (FGR).Methods:A total of 110 pregnant women with FGR admitted in Gansu Provincial Maternity and Child-care Hospital from June 2018 to June 2019 were selected as research objects. They were randomly divided into observation group and control group in a ratio of 1∶1, with 55 cases in each group. The control group was treated with low molecular heparin combined with aspirin, and the observation group was treated with HBO on the basis of the treatment of the control group for 6 weeks. The fetal growth was examined by color Doppler ultrasound. The clinical effect and fetal hemodynamic parameters before and after treatment were compared. The maternal and infant outcomes such as complications of pregnancy and neonatal conditions were statistically analyzed. The coagulation functions of pregnant women before and after treatment were also analyzed.Results:The effective rate of the observation group (83.64%) was significantly higher than that of the control group (63.64%) with statistical difference ( χ2=5.666, P=0.017). After treatment, the high systolic blood flow/late diastolic blood flow (S/D), resistance index (RI), and pulse index (PI) of the two groups were all remarkably decreased ( P<0.01), and those of the observation group were lower than those of the control group ( P<0.05) before and after treatment. There was no statistical difference in the comparisons of neonatal complications and pregnancy complications after treatment between the two groups ( P>0.05). The coagulation function index of both two groups after treatment were all improved than those before treatment with statistically significant difference ( P<0.05), but there was no statistically significant difference between the coagulation function index of the observation group and that of the control group after treatment( P>0.05). Conclusion:HBO combined with aspirin and low molecular heparin in the treatment of FGR can significantly improve the fetal hemodynamic parameters, and therefore improve the clinical efficacy.

This retrospective study aims to demonstrate the effect of antitubercular treatment (ATT) on the pregnancy outcomes and prognoses of patients with genital tuberculosis (GTB) who had received laparoscopy and/or hysteroscopy. This study included 78 patients with infertility and who were diagnosed with GTB through laparoscopy and/or hysteroscopy over the period of November 2005 to October 2015. The recruited patients were divided into ATT and nonATT groups on the basis of ATT duration. The GTB recurrence rates, menstrual patterns, and pregnancy outcomes of the patients were determined at follow-up. Among the 78 patients, 46 received ATT and 32 did not receive ATT. The menstrual volumes of patients in the ATT group significantly decreased relative to those of patients in the nonATT group. GTB did not recur among all patients regardless of treatment. A total of 11 pregnancies (36.7%) in the ATT group and 19 pregnancies (63.3%) in the nonATT group were observed. Pregnancy rates significantly differed (P = 0.002) between the two groups. ATT may decrease the menstrual volume and pregnancy rates of patients who were diagnosed with GTB through laparoscopy and/or hysteroscopy. In addition, ATT did not improve the prognosis of patients with chronic GTB.
Adult ; Antitubercular Agents ; therapeutic use ; China ; Female ; Fertilization ; Humans ; Hysteroscopy ; Infertility, Female ; etiology ; Laparoscopy ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Prognosis ; Retrospective Studies ; Tuberculosis, Female Genital ; complications ; drug therapy ; Young Adult

Brain-derived neurotrophic factor (BDNF)is both a neurotrophic substance and a neurotransmitter.BDNF and its receptors are highly expressed in enteric nervous system,intestinal mucosal epithelium and intestinal muscularis, which play an important role in regulating intestinal sensitivity and motility.This article reviewed the expression and role of BDNF in intestinal tract.