Non-small cell lung cancer(NSCLC)is the most common form of lung cancer,and patients with advanced disease generally have a poor prognosis.In recent years,immune checkpoint inhibitors(ICIs)have been approved as first-line therapy for patients with NSCLC lacking actionable driver mutations.Emerging evidence indicates that ICIs reduce tumor burden in some patients and may affect pulmonary ventila-tion and diffusion capacity,which are associated with clinical outcomes.This review summarizes baseline pulmonary function characteristics in advanced NSCLC,outlines in the impact of ICI therapy on lung function,and discusses potential mechanisms through which immunother-apy can influence pulmonary function,with the aim of guiding lung function monitoring and individualized management during ICI treat-ment.

Recently, intelligent care is gradually changing the traditional care way, and artificial intelligence (AI) application is gradually broadening in the field of assisted reproduction. This review systematically analyzes the AI application in multiple aspects of reproductive health care. It also indicates the challenge during the process, including data privacy, technical reliability, ethics and legal provisions, and humanistic care. Both the opportunities of AI in assisted reproduction are highlighted and the ensuing problems are analyzed in depth. The purpose is to provide ideas for future studies to ensure that AI technology can be safely, efficiently and responsibly integrated with the field of reproductive health care.

Objective:To conduct a scoping review of the role responsibilities and competencies of oncology nurse specialist in the management of cutaneous immune-related adverse events (cirAEs), with a view to providing scientific guidance and reference for nursing practice in the field of oncology immunotherapy.Methods:Using the scoping review methodology as the framework, the relevant literatures on oncology nurse specialist in the management of cirAEs in databases including PubMed, Web of Science, CINAHL, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, and China Biology Medicine from their inception to September 20, 2024 were systematically searched. Two researchers independently screened the included literature, extracted information, and conducted a summary analysis.Results:A total of 24 articles were included. Based on the summary and categorization of the literature, six categories were identified, including dynamic monitoring and assessment, classification and intervention of cirAEs, precise symptom management, multidisciplinary management, continuity of care, and specialized training, along with 18 related responsibility items.Conclusions:Oncology nurse specialist plays a significant role in the management of cirAEs. In the future, it should draw on the training models and curricula of advanced practice oncology nurses from abroad to optimize oncology nurse specialist training and nursing practices, thereby enhancing the professionalism of nursing services and the quality of patient care.

Recently, intelligent care is gradually changing the traditional care way, and artificial intelligence (AI) application is gradually broadening in the field of assisted reproduction. This review systematically analyzes the AI application in multiple aspects of reproductive health care. It also indicates the challenge during the process, including data privacy, technical reliability, ethics and legal provisions, and humanistic care. Both the opportunities of AI in assisted reproduction are highlighted and the ensuing problems are analyzed in depth. The purpose is to provide ideas for future studies to ensure that AI technology can be safely, efficiently and responsibly integrated with the field of reproductive health care.

Cancer cachexia is a complex multifactorial disease that can lead to significant reduction of skeletal muscle mass. MicroRNAs (miRNAs) are non-coding RNAs that are closely related to the development of cancer cachexia muscle atrophy. Studies have shown that miRNAs play an important role in the occurrence and development of cancer cachexia muscle atrophy by regulating various signaling pathways, but the mechanism by which miRNAs mediate cancer cachexia muscle atrophy has not been fully clarified. A systematic investigation of the role of miRNAs in cancer cachexia muscle atrophy may provide useful references for the precise treatment of patients with cancer cachexia muscle atrophy.

Non-small cell lung cancer(NSCLC)is the most common form of lung cancer,and patients with advanced disease generally have a poor prognosis.In recent years,immune checkpoint inhibitors(ICIs)have been approved as first-line therapy for patients with NSCLC lacking actionable driver mutations.Emerging evidence indicates that ICIs reduce tumor burden in some patients and may affect pulmonary ventila-tion and diffusion capacity,which are associated with clinical outcomes.This review summarizes baseline pulmonary function characteristics in advanced NSCLC,outlines in the impact of ICI therapy on lung function,and discusses potential mechanisms through which immunother-apy can influence pulmonary function,with the aim of guiding lung function monitoring and individualized management during ICI treat-ment.

Objective:To conduct a scoping review of the role responsibilities and competencies of oncology nurse specialist in the management of cutaneous immune-related adverse events (cirAEs), with a view to providing scientific guidance and reference for nursing practice in the field of oncology immunotherapy.Methods:Using the scoping review methodology as the framework, the relevant literatures on oncology nurse specialist in the management of cirAEs in databases including PubMed, Web of Science, CINAHL, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, and China Biology Medicine from their inception to September 20, 2024 were systematically searched. Two researchers independently screened the included literature, extracted information, and conducted a summary analysis.Results:A total of 24 articles were included. Based on the summary and categorization of the literature, six categories were identified, including dynamic monitoring and assessment, classification and intervention of cirAEs, precise symptom management, multidisciplinary management, continuity of care, and specialized training, along with 18 related responsibility items.Conclusions:Oncology nurse specialist plays a significant role in the management of cirAEs. In the future, it should draw on the training models and curricula of advanced practice oncology nurses from abroad to optimize oncology nurse specialist training and nursing practices, thereby enhancing the professionalism of nursing services and the quality of patient care.

Bone metastasis of lung cancer is relatively common in patients with advanced lung cancer, the treatment research of which has been made remarkable progress. In terms of systemic therapy, chemotherapy is the traditional treatment plan; targeted therapy shows strong efficacy in treating lung cancer patients with specific gene mutations; immunotherapy can bring new treatment options for lung cancer patients with bone metastasis by activating the body's immune system, which can be used alone or in combination with other therapies. Anti bone metastasis drugs such as bisphosphonates and denosumab play an important role in reducing bone destruction and bone-related adverse events. In terms of local therapy, radiotherapy can accurately irradiate tumor lesions and relieve pain symptoms; surgical treatment is suitable for specific bone metastasis to restore bone stability and function. In addition, analgesic treatment and psychological intervention can alleviate patients' pain and anxiety. These therapeutic advances bring new hope to patients with lung cancer bone metastasis.

Objective To analyze the status of occupational hazards in key positions of the small and micro book and newspaper printing enterprises in Beijing City. Methods A total of 16 small and micro printing enterprises in Beijing City were selected as the research subjects using the judgment sampling method. The status of occupational hazard was assessed using on-site occupational health investigations. The volatile chemical components in organic solvents such as inks and cleaning agents used in the workplace, the level of chemical hazardous agents in the air, and noise intensity were detected and analyzed. Results A total of 1 105 workers from 16 small and micro printing enterprises were included. The occupational hazard exposure rate was 22.2% (245/1 105), with chemical hazardous agents and noise exposure rates of 13.5% and 22.2%, respectively. The rate of compliance with occupational health training among the head of the enterprise and the occupational health management personnel, the regular detection rate of occupational hazards in last year, and the rate for the occupational health examination in last year were both 100.0%. The rate for annual update of occupational hazard project reporting was 93.8% (15/16). The usage rates of gas mask and noise-proof earplug were 68.8% (11/16) and 50.0% (8/16), respectively. The effectiveness rates of anti-toxic and noise-reduction facilities were 87.5% (14/16) and 62.5% (10/16). The sign setting rates of chemical hazardous agents and noise warning were 93.8% (15/16). Acetone and isopropanol were found in ink and cleaning agents in 15 printing enterprises, while toluene, xylene, and ethylbenzene were found in three, two, and one enterprise, respectively. Benzene, 1,2-dichloroethane, n-hexane, and trichloroethylene were not found in all 16 enterprises. Both the exposure concentration of short term and exposure concentration of time weighted average of the above chemical hazards were lower than the lower limit of quantitation of the detection method in the workplace and work site air among the 16 printing enterprises, and none of concentration was exceeded the national standard. A total of 240 noise work sites were detected, and the national noise-exceeding rate was 11.2%(27/240). Conclusion Noise hazards are prominent in the small and micro printing enterprises in Beijing City, and attention should be paid to the prevention and protection of noise-exposure. The usage rate of personal protective equipment is not high, and the training and on-site supervision management of protective equipment wearing in workers should be strengthened.

The occurrence rate of primary liver cancer in malignant tumors ranks sixth in the world, and the mortality rate ranks third, with a poor prognosis and a five-year survival rate of less than 5%. Most patients with liver cancer in China are found to be in the intermediate and advanced stages, and a targeted immunotherapy combination has become the main treatment option. However, many patients have underlying liver lesions, and their liver function cannot meet the requirements of targeted immunotherapy, which directly affects the treatment of liver cancer patients. Therefore, it is very important to optimize the patient's liver function in a timely manner so as to obtain the opportunity for anti-tumor therapy. This article reviews the current status and response strategies before liver injury related to targeted immune therapy in patients with primary liver cancer.