Selenium binding protein 1(SELENBP1)is a protein related to selenium metabolism.Studies have found that SELENBP1 is abnormally expressed in various cancer cells,and its expression level is closely related to tumor occurrence,development,metastasis,and prognosis.Therefore,SELENBP1 is widely concerned,and its role in bladder cancer is being studied in-depth.This article mainly summarizes the expression regulation,biological functions,and potential molecular pathways of SELENBP1 in thyroid cancer,colorectal cancer,non-small cell lung cancer,prostate cancer,oral squamous cell cancer,and bladder cancer.The research results may provide a reference for understanding the mechanisms of SELENBP1 in cancer cells and offer new ideas and targets for tumor diagnosis and prevention.

To evaluate the therapeutic effectiveness and safety of a novel gastrointestinal occluder device for gastrobronchial fistula. Data of 5 patients diagnosed as having gastrobronchial fistula who received treatment by a novel gastrointestinal occluder device at the First Affiliated Hospital of Nanjing Medical University from July to August 2020 were retrospectively analyzed. The total operation time, occluding time, intraoperative and postoperative complications, postoperative hospital stay and patients′ satisfaction were reviewed. Regular follow-up was conducted, and the short-term curative effect of occluding was evaluated 1 month after operation.All patients were males with age of 58-69 years. The course of fistula ranged 3-16 months and the diameter ranged 0.3-1.0 cm. All 5 patients achieved technical success with operation time of 38-88 minutes and occluding time of 8-24 minutes. The postoperative hospital stay ranged 3-5 days and the patients′ satisfaction score was 10. No severe complications occurred during or after operation. One month after endoscopic therapy, fistula was completely occluded in 4 patients. One patient died due to severe pulmonary infection and multiple organ failure although the bucking symptom after drinking and eating recovered before. Endoscopic closure of gastrointestinal fistula by means of the novel gastrointestinal occluder device is safe and effective.