Objective:To explore surgical approaches to preserve fertility and assisted reproductive technology strategies for pregnancy in patients with recurrent borderline ovarian tumors.Methods:A case of recurrent borderline ovarian tumor was retrospectively analyzed. The patient was admitted several times and underwent right adnexectomy and cysts debulking in the left ovary for recurrent borderline tumors. The patient was infertile for 3 years without contraception. Considering the patient's strong desire for childbearing, ovulation treatment was performed with a microstimulation protocol. The left ovarian tumor enlarged significantly during the process of assisted reproductive technology for pregnancy assistance, left oophorectomy was carried by laparoscopic and healthy ovarian cortex was frozen to preserve fertility.Results:The patient underwent 5 times of controlled ovulation cycles, acquired 7 available embryos. The patient had a successful pregnancy and delivered a live baby on the third frozen embryo cycle transfer. The patient still had 2 embryos and 3 pieces of ovarian tissue frozen.Conclusion:Patients with borderline ovarian tumors who are young and have fertility needs can undergo fertility preserving surgery and assisted reproductive technology to help them get pregnant, which may lead to a higher risk of disease recurrence to a certain extent, but it does not affect the quality of patients' survival and allows the patient to achieve her fertility aspirations.

Objective:To explore surgical approaches to preserve fertility and assisted reproductive technology strategies for pregnancy in patients with recurrent borderline ovarian tumors.Methods:A case of recurrent borderline ovarian tumor was retrospectively analyzed. The patient was admitted several times and underwent right adnexectomy and cysts debulking in the left ovary for recurrent borderline tumors. The patient was infertile for 3 years without contraception. Considering the patient's strong desire for childbearing, ovulation treatment was performed with a microstimulation protocol. The left ovarian tumor enlarged significantly during the process of assisted reproductive technology for pregnancy assistance, left oophorectomy was carried by laparoscopic and healthy ovarian cortex was frozen to preserve fertility.Results:The patient underwent 5 times of controlled ovulation cycles, acquired 7 available embryos. The patient had a successful pregnancy and delivered a live baby on the third frozen embryo cycle transfer. The patient still had 2 embryos and 3 pieces of ovarian tissue frozen.Conclusion:Patients with borderline ovarian tumors who are young and have fertility needs can undergo fertility preserving surgery and assisted reproductive technology to help them get pregnant, which may lead to a higher risk of disease recurrence to a certain extent, but it does not affect the quality of patients' survival and allows the patient to achieve her fertility aspirations.

Objective To optimize preparation process of Zushima Gel Cream. Methods The comprehensive evaluation set sensory evaluation, initial adhesive force, viscous force, and peeling strength score as indexes. The mixing time, refining temperature, mixing speed, and powder adding sequence were investigation factors. Orthogonal experiment was used to optimize forming process. Results Conditions of optimized preparation process were as following: add Zushima powder in Viscomate NP-700 and glycerol; mixing time was 5 min; refining temperature was 40 ℃; mixing speed was 100 r/min. Conclusion The preparation process is good and optimized Zushima Gel Cream has a good adhesive force, good glossiness and excipients. The preparation process is good.