Purpose: To analyze the frequency and clinical characteristics of ocular injuries in patients with prior blowout fractures who experience new blunt trauma, and to assess whether old orbital fractures provide a protective effect against subsequent ocular trauma. Methods: The medical records of 1,315 ocular trauma patients were reviewed. A total of 927 patients who had orbital or facial computed tomography scans and ophthalmologist evaluations were considered. After applying exclusion criteria, 568 patients with 581 affected eyes were included in the final analysis. The patients were divided into two groups based on the presence of old blowout fractures, identified on computed tomography scan. The clinical characteristics and the frequency of ocular injuries were compared between the two groups. The risk of ocular injury according to the presence of old blowout fracture ware studied using multiple logistic regression after controlling age and sex. Results: Among the 581 eyes examined, 140 (24.1%) had old blowout fractures. The incidence of intraocular complications was significantly higher in the no orbital fracture group compared to the old blowout fracture group (20.4% vs. 2.1%, p < 0.001). Specifically, the incidence of complications such as gross hyphema (p = 0.001), globe rupture (p = 0.006), and vitreous hemorrhage (p = 0.027) was significantly greater in the group without old blowout fractures than in those with them. Multiple logistic regression showed that the presence of old blowout fractures was significantly associated with reduced risk of ocular injury (p < 0.001). Conclusions The patients with old blowout fractures had a lower risk of ocular injuries following subsequent blunt trauma. The findings suggest that old fractures may provide protective effect. These results may have important implications for the clinical management of patients at risk of recurrent orbital trauma.

Background: This study focuses on the development of a hydrogel wound patch incorporating natural extracts, designed to function as a sun patch. By maintaining a moist environment and delivering bioactive compounds, the patch promotes wound healing while also providing cooling and ultraviolet (UV) protection. This dual-purpose approach enhances skin recovery and shields damaged areas from external stressors. The study aims to optimize the formulation and evaluate its efficacy for both therapeutic and cosmetic applications. Methods: Hydrogel solutions prepared using acrylamide, glycerol, and carboxymethyl cellulose were enriched with extracts from Saururus chinensis, Styrax japonicus, and Centella asiatica. The enriched solutions were processed into patches and tested for their adhesion, cooling effects, and UV protective abilities. Additionally, the wound healing efficacy was evaluated in a mouse model. Results: The hydrogel patches demonstrated comparable adhesion properties, effective skin cooling, and high UV protection rates similar to those of commercially available products. In the mouse model, the patches significantly improved wound closure and tissue regeneration in the experimental group as compared to the control group. Conclusion The study confirms that hydrogel sun patches enriched with natural extracts have the ability to effectively promote wound healing and offer substantial UV protection and cooling benefits, demonstrating their potential medical and cosmetic applications.

Purpose: To analyze the frequency and clinical characteristics of ocular injuries in patients with prior blowout fractures who experience new blunt trauma, and to assess whether old orbital fractures provide a protective effect against subsequent ocular trauma. Methods: The medical records of 1,315 ocular trauma patients were reviewed. A total of 927 patients who had orbital or facial computed tomography scans and ophthalmologist evaluations were considered. After applying exclusion criteria, 568 patients with 581 affected eyes were included in the final analysis. The patients were divided into two groups based on the presence of old blowout fractures, identified on computed tomography scan. The clinical characteristics and the frequency of ocular injuries were compared between the two groups. The risk of ocular injury according to the presence of old blowout fracture ware studied using multiple logistic regression after controlling age and sex. Results: Among the 581 eyes examined, 140 (24.1%) had old blowout fractures. The incidence of intraocular complications was significantly higher in the no orbital fracture group compared to the old blowout fracture group (20.4% vs. 2.1%, p < 0.001). Specifically, the incidence of complications such as gross hyphema (p = 0.001), globe rupture (p = 0.006), and vitreous hemorrhage (p = 0.027) was significantly greater in the group without old blowout fractures than in those with them. Multiple logistic regression showed that the presence of old blowout fractures was significantly associated with reduced risk of ocular injury (p < 0.001). Conclusions The patients with old blowout fractures had a lower risk of ocular injuries following subsequent blunt trauma. The findings suggest that old fractures may provide protective effect. These results may have important implications for the clinical management of patients at risk of recurrent orbital trauma.

Purpose: To analyze the frequency and clinical characteristics of ocular injuries in patients with prior blowout fractures who experience new blunt trauma, and to assess whether old orbital fractures provide a protective effect against subsequent ocular trauma. Methods: The medical records of 1,315 ocular trauma patients were reviewed. A total of 927 patients who had orbital or facial computed tomography scans and ophthalmologist evaluations were considered. After applying exclusion criteria, 568 patients with 581 affected eyes were included in the final analysis. The patients were divided into two groups based on the presence of old blowout fractures, identified on computed tomography scan. The clinical characteristics and the frequency of ocular injuries were compared between the two groups. The risk of ocular injury according to the presence of old blowout fracture ware studied using multiple logistic regression after controlling age and sex. Results: Among the 581 eyes examined, 140 (24.1%) had old blowout fractures. The incidence of intraocular complications was significantly higher in the no orbital fracture group compared to the old blowout fracture group (20.4% vs. 2.1%, p < 0.001). Specifically, the incidence of complications such as gross hyphema (p = 0.001), globe rupture (p = 0.006), and vitreous hemorrhage (p = 0.027) was significantly greater in the group without old blowout fractures than in those with them. Multiple logistic regression showed that the presence of old blowout fractures was significantly associated with reduced risk of ocular injury (p < 0.001). Conclusions The patients with old blowout fractures had a lower risk of ocular injuries following subsequent blunt trauma. The findings suggest that old fractures may provide protective effect. These results may have important implications for the clinical management of patients at risk of recurrent orbital trauma.

Purpose: To analyze the frequency and clinical characteristics of ocular injuries in patients with prior blowout fractures who experience new blunt trauma, and to assess whether old orbital fractures provide a protective effect against subsequent ocular trauma. Methods: The medical records of 1,315 ocular trauma patients were reviewed. A total of 927 patients who had orbital or facial computed tomography scans and ophthalmologist evaluations were considered. After applying exclusion criteria, 568 patients with 581 affected eyes were included in the final analysis. The patients were divided into two groups based on the presence of old blowout fractures, identified on computed tomography scan. The clinical characteristics and the frequency of ocular injuries were compared between the two groups. The risk of ocular injury according to the presence of old blowout fracture ware studied using multiple logistic regression after controlling age and sex. Results: Among the 581 eyes examined, 140 (24.1%) had old blowout fractures. The incidence of intraocular complications was significantly higher in the no orbital fracture group compared to the old blowout fracture group (20.4% vs. 2.1%, p < 0.001). Specifically, the incidence of complications such as gross hyphema (p = 0.001), globe rupture (p = 0.006), and vitreous hemorrhage (p = 0.027) was significantly greater in the group without old blowout fractures than in those with them. Multiple logistic regression showed that the presence of old blowout fractures was significantly associated with reduced risk of ocular injury (p < 0.001). Conclusions The patients with old blowout fractures had a lower risk of ocular injuries following subsequent blunt trauma. The findings suggest that old fractures may provide protective effect. These results may have important implications for the clinical management of patients at risk of recurrent orbital trauma.

Purpose: To analyze the frequency and clinical characteristics of ocular injuries in patients with prior blowout fractures who experience new blunt trauma, and to assess whether old orbital fractures provide a protective effect against subsequent ocular trauma. Methods: The medical records of 1,315 ocular trauma patients were reviewed. A total of 927 patients who had orbital or facial computed tomography scans and ophthalmologist evaluations were considered. After applying exclusion criteria, 568 patients with 581 affected eyes were included in the final analysis. The patients were divided into two groups based on the presence of old blowout fractures, identified on computed tomography scan. The clinical characteristics and the frequency of ocular injuries were compared between the two groups. The risk of ocular injury according to the presence of old blowout fracture ware studied using multiple logistic regression after controlling age and sex. Results: Among the 581 eyes examined, 140 (24.1%) had old blowout fractures. The incidence of intraocular complications was significantly higher in the no orbital fracture group compared to the old blowout fracture group (20.4% vs. 2.1%, p < 0.001). Specifically, the incidence of complications such as gross hyphema (p = 0.001), globe rupture (p = 0.006), and vitreous hemorrhage (p = 0.027) was significantly greater in the group without old blowout fractures than in those with them. Multiple logistic regression showed that the presence of old blowout fractures was significantly associated with reduced risk of ocular injury (p < 0.001). Conclusions The patients with old blowout fractures had a lower risk of ocular injuries following subsequent blunt trauma. The findings suggest that old fractures may provide protective effect. These results may have important implications for the clinical management of patients at risk of recurrent orbital trauma.

This article discusses studies and real-world experiences related to the clinical application of artificial intelligence-based computer-aided detection (AI-CAD) software (LuCAS-plus, Monitor Corporation) in detecting pulmonary nodules. During clinical trials for lung cancer screening, AI-CAD exhibited performance comparable to that of medical professionals in terms of sensitivity and specificity. Studies revealed that applying AI-CAD for diagnosing pulmonary metastases led to high detection rates. The use of a nodule matching algorithm in diagnosing pulmonary metastases significantly reduced false non-metastasis results. In clinical settings, implementing AI-CAD enhanced the efficiency of pulmonary nodule detection, saving time and effort during CT reading. Overall, AI-CAD is expected to offer substantial support for lung cancer screening and the interpretation of chest CT scans for malignant tumor surveillance.

Objective: Classification guides the surgical approach and predicts prognosis. However, existing classifications of spinal schwannomas often result in a high ‘unclassified’ rate. Here, we aim to develop a new comprehensive classification for spinal schwannomas based on their presumed origin. We compared the new classification with the existing classifications regarding the rate of ‘unclassified’. Finally, we assessed the surgical strategies, outcomes, and complications according to each type of the new classification. Methods: A new classification with 9 types was created by analyzing the anatomy of spinal nerves and the origin of significant tumor portions and cystic components in preoperative magnetic resonance images. A total of 482 patients with spinal schwannomas were analyzed to compare our new classification with the existing classifications. We defined ‘unclassified’ as the inability to classify a patient with spinal schwannoma using the classification criteria. Surgical approaches and outcomes were also aligned with our new classification. Results: Our classification uniquely reported no ‘unclassified’ cases, indicating full applicability. Also, the classification has demonstrated usefulness in predicting the surgical outcome with the approach planned. Gross total removal rates reached 88.0% overall, with type 1 and type 2 tumors at 95.3% and 96.0% respectively. The approach varied with tumor type, with laminectomy predominantly used for types 1, 2, and 9, and facetectomy with posterior fixation used for type 3 tumors. Conclusion The new classification for spinal schwannomas based on presumed origin is applicable to all spinal schwannomas. It could help plan a surgical approach and predict its outcome, compared with existing classifications.

Purpose: Despite the recent success of Bruton’s tyrosine kinase (BTK) inhibitors for the treatment of Waldenstrom macroglobulinemia (WM), their indefinite treatment duration ultimately tantamount to substantial financial and emotional burden. On the other hand, fixed duration of proteasome inhibitors (PI) have shown rapid and reasonable response in WM treatment. Despite the well-known synergism between PI and immunomodulatory drugs (IMiD), there is no trials evaluating such combination in WM. Materials and Methods: Based on above, we designed this phase II study to investigate the efficacy and safety of 6 cycles of 28-day bortezomib-thalidomide-dexamethasone (VTD) regimen for treatment-naïve WM. Results: A total of 15 patients were enrolled: major response rate was 64.3%, and overall response rate was 78.6%. During the median follow-up of 41 months, median progression-free survival (PFS) was 13 months and overall survival 40 months. For responders, median duration of response was 13 months and median PFS 19 months. The most common adverse event (AE) of any grade was constipation (57.1%). The most common grade ≥ 3 AE was anemia (21.4%). Conclusion All in all, we hereby provide proof-of-concept that PI + IMiD may be an attractive backbone for fixed duration treatment. It should be noted that granting the same level of access to newer drugs globally is virtually impossible. Thus efforts to develop regimens using readily available drugs to yield similar or adequate treatment outcomes should not be disregarded. In this sense, we believe our study holds its place for its novelty and eloquently addresses achieving the daunting societal quest of health equity.

Purpose: Optimal treatment for stage IIIA/N2 non–small cell lung cancer (NSCLC) is controversial. We aimed to assess the efficacy and safety of adjuvant pembrolizumab for stage IIIA/N2 NSCLC completely resected after neoadjuvant concurrent chemoradiation therapy (CCRT). Materials and Methods: In this open-label, single-center, single-arm phase 2 trial, patients with stage IIIA/N2 NSCLC received adjuvant pembrolizumab for up to 2 years after complete resection following neoadjuvant CCRT. The primary endpoint was disease-free survival (DFS). Secondary endpoints included overall survival (OS) and safety. As an exploratory biomarker analysis, we evaluated the proliferative response of blood CD39+PD-1+CD8+ T cells using fold changes in the percentage of proliferating Ki-67+ cells from days 1 to 7 of cycle 1 (Ki-67D7/D1). Results: Between October 2017 and October 2018, 37 patients were enrolled. Twelve (32%) and three (8%) patients harbored EGFR and ALK alterations, respectively. Of 34 patients with programmed cell death ligand 1 assessment, 21 (62%), nine (26%), and four (12%) had a tumor proportion score of < 1%, 1%-50%, and ≥ 50%, respectively. The median follow-up was 71 months. The median DFS was 22.4 months in the overall population, with a 5-year DFS rate of 29%. The OS rate was 86% at 2 years and 76% at 5 years. Patients with tumor recurrence within 6 months had a significantly lower Ki-67D7/D1 among CD39+PD-1+CD8+ T cells than those without (p=0.036). No new safety signals were identified. Conclusion Adjuvant pembrolizumab may offer durable disease control in a subset of stage IIIA/N2 NSCLC patients after neoadjuvant CCRT and surgery.