Objective To investigate the epidemiological characteristics and risk factors of non-alcoholic fatty liver disease in Jincheng between 2015 and 2020. Methods Clinical data of 8,578 medical check-ups at Physical Examination Center of ou hospital from January 2015 to December 2020 were retrospectively selected. The prevalence of non-alcoholic fatty liver disease in the last 5 years was recorded, and Logistic regression was utilized to identify the risk factors for the development of non-alcoholic fatty liver disease. Results The overall prevalence of non-alcoholic fatty liver disease in Jincheng was 14.57% in 2015-2020. The prevalence of non-alcoholic fatty liver disease was higher in men than in women (16.99% vs 10.98%) and highest in the 40-59 age group (18.76%). No statistical difference was reported in blood urea nitrogen (BUN) and serum creatinine (Scr) between groups (P>0.05), while statistical difference was found in diabetes, hypertension, body mass index (BMI), waist circumference, weekly exercise frequency, daily vegetable intake, triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT) and uric acid (UA) between two groups (P<0.05). Multivariate Logistic regression analysis denoted that BMI (OR=2.794, 95% CI: 1.745-4.550), waist circumference (OR=2.586, 95% CI: 1.585-4.299), diabetes (OR=0.644, 95% CI: 1.425-2.781), hypertension (OR=1.479, 95% CI: 1.121-2.290), weekly exercise ≥6h (OR=0.617, 95% CI: 0.519-0.709), daily vegetable intake ≥300g (OR=0.590, 95% CI: 0.467-0.652), TG (OR=1.481, 95% CI: 1.122-1.996), TC (OR=1.562, 95% CI:1.143-2.135), LDL-C (OR=1.440, 95% CI: 1.139-2.048), HDL-C (OR=0.656 , 95% CI: 0.587-0.783) , ALT (OR=1.591, 95% CI: 1.056-2.183), and UA (OR=1.412, 95% CI: 1.009-1.887) were risk factors for non-alcoholic fatty liver disease (P<0.05) . Conclusion The prevalence of non-alcoholic fatty liver disease in Jincheng City from 2015 to 2020 is 14.57%, the prevalence of males is higher than that of females, and the prevalence rate is the highest in the 40-59 age group. Moreover , diabetes mellitus , hypertension , BMI , waist circumference , weekly exercise , daily vegetable intake , serum TG, TC, LDL-C, HDL-C, ALT, and UA are all associated with the risk of the disease.

With the rapid development of interventional radiology technology, the occupational health risk of interventional radiation workers has attracted increasing attention. This paper reviews recent studies on hematological changes, DNA damage and molecular-level changes, cancer, eye lens, and other health impairments among interventional radiation workers. The aim is to provide an overview of the current research progress as well as a scientific basis for the implementation of targeted protective measures to improve the occupational health level of interventional radiology workers.

Objective:To evaluate the feasibility of measurement and characteristics of intraocular lens (IOL) tilt using the swept-source optical coherence tomography (SS-OCT) biometer (IOLMaster 700) and to explore its potentially relevant parameters.Methods:A cross-sectional study was conducted.Two hundred and forty-two eyes (119 right eyes, 123 left eyes) of 185 patients after phacoemulsification and IOL implantation were included in Beijing Tongren Hospital from July to September 2018.The IOL position, angle κ, angle α, corneal curvature, anterior chamber depth (ACD), pupil diameter (PD), and axial length (AL) were obtained by IOLMaster 700, and the IOL tilt direction and magnitude were calculated.The within-subject standard deviation and intraclass correlation coefficient were used to evaluate the repeatability of three IOL tilt measurements.Binocular symmetry of IOL tilt and the correlation between IOL tilt and different influencing factors were evaluated by Pearson linear correlation analysis or Spearman rank correlation analysis.Influencing factors for IOL tilt were assessed by multiple linear regression analysis.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University (No.TRECKY2018-049). Patients were informed of the purpose and methods of this study and signed the written informed consent.Results:The repeatability of IOL tilt measurements was excellent with a within-subject standard deviation of 5.16° for IOL tilt direction and 0.13° for IOL tilt magnitude.IOL tilt was mirror symmetric in both eyes.The IOL tilt direction in right eyes ranged from -89.60° to 87.53° with a mean of (18.85±29.65)°, and the tilt magnitude ranged from 1.32° to 7.05° with a mean of (4.16±1.26)°.The IOL tilt direction in left eyes ranged from -84.30° to 89.44° with a mean of (21.17±32.38)°, and the tilt magnitude ranged from 0.58° to 7.40° with a mean of (3.80±1.31)°.There were moderate and weak positive correlations of IOL tilt direction and tilt magnitude between both eyes ( r=0.473, P<0.001; r=0.335, P=0.011). IOL tilt magnitude was weakly positively correlated with angle α and IOL diopter ( rs=0.272, P=0.003; r=0.285, P=0.002), and was weakly negatively correlated with ACD, PD and AL ( r=-0.303, P=0.001; r=-0.233, P=0.011; rs=-0.331, P<0.001). In backward stepwise regression analysis, the regression equation of IOL tilt magnitude, angle α, ACD, PD, AL and IOL diopter in multiple linear regression analysis was as follows: IOL tilt magnitude=10.503+ 1.456×angle α-0.532×ACD-0.196×AL ( R2=0.400; F=8.588, P<0.001). Conclusions:The SS-OCT biometer can be an effective method to assess IOL tilt.IOL tilt is mirror symmetric between the right eyes and left eyes.

Objective:To discuss the characteristics of ultrasound diagnosis of optic disc capillary hemangioma.Methods:The study analyzed retrospectively 7 cases of optic disc capillary hemangioma diagnosed in the Beijing Tongren Hospital from 2015 to 2018. The size, morphology, internal echo, and secondary changes of the lesion were analyzed during ultrasound examination.Color Doppler flow imaging was used to check the blood flow in the lesion.Results:Pre-optic disc occupying lesions could be detected in the ultrasound images of the 7 cases. Lesion size: average base diameters (5.39±1.90)mm×(4.79±1.28)mm, average height (3.61±1.37)mm. Lesion morphology: 5 cases were round, and 2 cases were irregular. Echo within the lesion: 3 cases had medium echo inside the lesion, and 4 cases had high echo inside the lesion. Internal echo characteristics: 5 cases had uniform echo, and 2 cases had uneven echo. Secondary changes: 6 cases had secondary retinal detachment and vitreous opacity, and 1 cases was accompanied by retinal hemangioma in other parts. In all cases, blood flow signals could be detected inside the space-occupying lesions, which were in the form of branches, stripes or spots, and the blood flow spectrum showed a parallel spectrum of arteries and veins.Conclusions:Ultrasound examination of optic disc capillary hemangioma has certain characteristics, which can provide a valuable follow-up basis for clinical diagnosis.

Objective:To investigate the effect and mechanism of hyperbaric oxygen combined with Wenshenyiqi granules on airway inflammation and oxidative stress in rats with chronic obstructive pulmonary disease (COPD).Methods:A total of 50 SD rats were randomly divided into control group (normal saline), model group (normal saline), Wenshenyiqi granules group (1.5 g/kg Wenshenyiqi granules), hyperbaric oxygen group (0.20 MPa hyperbaric oxygen) and combination group (0.20 MPa hyperbaric oxygen + 1.5 g/kg Wenshenyiqi granules) based on the order sorted by body mass, with 10 rats in each group. The COPD model was established in all the rats but the control group through smoking combined with airway infusion of lipopolysaccharide. After modeling, each group received treatment for 4 weeks according to the protocol. The pulmonary function, blood gas indicators, expressions of inflammatory factors in Bronchoalveolar Lavage Fluid (BALF), oxidative stress indicators in lung tissue, peroxisome proliferator activated receptor γ (PPARγ), nuclear factor-κB (NF-κB) mRNA, and protein expression were compared in each group.Results:After 4 weeks of treatment, the ratio of forced expiratory volume at 0.3 s to forced vital capacity (FEV 0.3/FVC) in the control group, the model group, the Wenshenyiqi granules group, the hyperbaric oxygen group, and the combination group was (83.69±5.24), (62.30±6.07), (75.26±7.15), (75.87±6.02), and (81.85±6.33), respectively. The arterial partial pressure of carbon dioxide (PaCO 2) was (48.61±3.10), (57.92±4.23), (54.14±3.19), (54.08±3.62), and (49.32±3.87) mm Hg, respectively. Compared with the control group, the FEV 0.3/FVC was decreased and PaCO 2 increased in the model group ( P<0.05). Compared with the model group, the FEV 0.3/FVC was increased in the Wenshenyiqi granules group, the hyperbaric oxygen group, and the combination group, while the PaCO 2 was decreased ( P<0.05). Compared with the Wenshenyiqi granules group and the hyperbaric oxygen group, the combination group had higher FEV 0.3/FVC and lower PaCO 2 ( P<0.05). Compared with the control group, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), monocyte chemoattractant protein-1 (MCP-1) in BALF, and malondialdehyde (MDA), expression levels of NF-κB mRNA and protein in lung tissues were increased in the model group, while superoxide dismutase (SOD), expression levels of PPARγ mRNA and protein were decreased ( P<0.05). Compared with the model group, TNF-α, IL-1β, and MCP-1 in BALF, MDA and expression levels of NF-κB mRNA and protein in lung tissues were decreased in the Wenshenyiqi granules group, the hyperbaric oxygen group, and the combination group, with those of the combination group were lower than those of the Wenshenyiqi granules group and the hyperbaric oxygen group ( P<0.05). Compared with the model group, the SOD and expression levels of PPARγ mRNA and protein in the lung tissues of the Wenshenyiqi granules group, the hyperbaric oxygen group, and the combination group were all increased, with those of the combination group were higher than those of the Wenshenyiqi granules group and the hyperbaric oxygen group ( P<0.05). Conclusion:Hyperbaric oxygen combined with Wenshenyiqi granules can effectively inhibit airway inflammation and oxidative stress in rats with COPD, which may be achieved through PPARγ signaling pathway.

Objective:To investigate the effect and mechanism of hyperbaric oxygen combined with Wenshenyiqi granules on airway inflammation and oxidative stress in rats with chronic obstructive pulmonary disease (COPD).Methods:A total of 50 SD rats were randomly divided into control group (normal saline), model group (normal saline), Wenshenyiqi granules group (1.5 g/kg Wenshenyiqi granules), hyperbaric oxygen group (0.20 MPa hyperbaric oxygen) and combination group (0.20 MPa hyperbaric oxygen + 1.5 g/kg Wenshenyiqi granules) based on the order sorted by body mass, with 10 rats in each group. The COPD model was established in all the rats but the control group through smoking combined with airway infusion of lipopolysaccharide. After modeling, each group received treatment for 4 weeks according to the protocol. The pulmonary function, blood gas indicators, expressions of inflammatory factors in Bronchoalveolar Lavage Fluid (BALF), oxidative stress indicators in lung tissue, peroxisome proliferator activated receptor γ (PPARγ), nuclear factor-κB (NF-κB) mRNA, and protein expression were compared in each group.Results:After 4 weeks of treatment, the ratio of forced expiratory volume at 0.3 s to forced vital capacity (FEV 0.3/FVC) in the control group, the model group, the Wenshenyiqi granules group, the hyperbaric oxygen group, and the combination group was (83.69±5.24), (62.30±6.07), (75.26±7.15), (75.87±6.02), and (81.85±6.33), respectively. The arterial partial pressure of carbon dioxide (PaCO 2) was (48.61±3.10), (57.92±4.23), (54.14±3.19), (54.08±3.62), and (49.32±3.87) mm Hg, respectively. Compared with the control group, the FEV 0.3/FVC was decreased and PaCO 2 increased in the model group ( P<0.05). Compared with the model group, the FEV 0.3/FVC was increased in the Wenshenyiqi granules group, the hyperbaric oxygen group, and the combination group, while the PaCO 2 was decreased ( P<0.05). Compared with the Wenshenyiqi granules group and the hyperbaric oxygen group, the combination group had higher FEV 0.3/FVC and lower PaCO 2 ( P<0.05). Compared with the control group, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), monocyte chemoattractant protein-1 (MCP-1) in BALF, and malondialdehyde (MDA), expression levels of NF-κB mRNA and protein in lung tissues were increased in the model group, while superoxide dismutase (SOD), expression levels of PPARγ mRNA and protein were decreased ( P<0.05). Compared with the model group, TNF-α, IL-1β, and MCP-1 in BALF, MDA and expression levels of NF-κB mRNA and protein in lung tissues were decreased in the Wenshenyiqi granules group, the hyperbaric oxygen group, and the combination group, with those of the combination group were lower than those of the Wenshenyiqi granules group and the hyperbaric oxygen group ( P<0.05). Compared with the model group, the SOD and expression levels of PPARγ mRNA and protein in the lung tissues of the Wenshenyiqi granules group, the hyperbaric oxygen group, and the combination group were all increased, with those of the combination group were higher than those of the Wenshenyiqi granules group and the hyperbaric oxygen group ( P<0.05). Conclusion:Hyperbaric oxygen combined with Wenshenyiqi granules can effectively inhibit airway inflammation and oxidative stress in rats with COPD, which may be achieved through PPARγ signaling pathway.

Objective:To compare the agreement of biometric parameters measured by a new swept-source optical coherence tomography IOLMaster 700 and a new Scheimpflug imaging combined with partial coherence interferometry biometer Pentacam AXL in cataractous eyes.Methods:A cross-sectional study was performed.A total of 146 eyes from 76 cataract patients were enrolled in Beijing Tongren Eye Center from 2 to 11 in January 2018, including 69 eyes in 36 males and 77 eyes in 40 females, the age ranged from 35 to 88 years, the mean age was (64.52±11.36) years.Axial length (AL), mean keratometry (Km), anterior chamber depth (ACD), central corneal thickness (CCT) and white-to-white (WTW) were measured with IOLMaster 700 and Pentacam AXL, respectively.The differences and correlations of the biometry parameters between the two devices were assessed.Bland-Altman method was used to evaluate the agreement of these parameters between the two devices and the 95% limits of agreement was calculated.This study adhered to the tenets of the Declaration of Helsinki and was approved by an Ethics Committee of Beijing Tongren Hospital (TRECKY2018-049).Results:The mean values of the AL measured by IOLMaster 700 and Pentacam AXL were (24.03±1.72)mm and (23.98±1.73)mm, Km were (44.04±1.71)D and (43.88±1.72)D, ACD were (3.24±0.47)mm and (3.28±0.47)mm, WTW were (11.82±0.51)mm and (11.49±0.49)mm, respectively.Compared with the values in Pentacam AXL, the AL, Km and WTW were larger while ACD was smaller in IOLMaster 700 with significant differences ( t=18.06, 8.94, 23.83, -15.36, all at P<0.01). The mean CCT values from the IOLMaster 700 and Pentacam AXL were (534.18±30.12)μm and (533.42±28.71)μm, respectively, with no significant difference ( t=1.04, P=0.30). The AL, Km, ACD, CCT and WTW from IOLMaster 700 were highly correlated with those from Pentacam AXL ( r=0.999, 0.992, 0.998, 0.956, 0.942; all at P<0.01). The Bland Altman analysis showed that the 95% limits of agreement of AL, Km, ACD, CCT and WTW were-0.02-0.11 mm, -0.27-0.59 D, -0.10-0.02 mm, -16.5-18.1 μm and 0.00-0.67 mm. Conclusions:IOLMaster 700 and Pentacam AXL have good agreements and narrow 95% limits of agreement in the measurements of AL, ACD, CCT, which can be clinically interchangeable.The 95% limits of agreement of WTW and Km are out of the clinically acceptable range, so the WTW and Km measured by the two devices are not interchangeable.

Objective To observe the application value with color Doppler flow imaging (CDFI) in the detection ofmacular diseases in senile cataract.Methods A cross-sectional descriptive study.From December 1 to December 30,2017,720 senile cataract patients (1380 eyes) diagnosed in Beijing Tongren Eye Center were included in this study.There were 330 males (629 eyes) and 390 females (751 eyes),with the mean age of 70.35 ± 19.05 years.There were 716 right eyes and 664 left eyes,with the visual acuity 0.05-0.8.The fundus of all the patients can be observed.All patients were examined by OCT using Cirrus HD-Model 5000 produced by German Carl Zeiss company and CDFI using MyLab90 color Doppler ultrasound system produced by ESAOTE S.P.A.Comparing the detection rate of macular lesions between the two methods by using X2 test.Using statistical methods to evaluate diagnostic tests,a crosstabulation was made to compare the consistency of frequency-domain OCT and CDFI in the diagnosis of macular lesions.Logistic regression analysis of correlation between detection of CDFI macular lesions and central foveal thickness (CFT),average thickness (AT),with or without macular anterior membrane,retinal folds,retinal cystoid edema,hard exudation,macular hole or lamellar macular hole,superficial detachment of neuroepithelium,detachment of pigment epithelium,vitreous macular traction.Results Two hundreds and thirty-nine eyes (17.3％) showed macular disease by OCT,and 161 eyes (11.7％) showed the abnormal echo in the macular region by CDFI.The detection rate of the macular disease between two methods were statistically significant (χ2=851.661,P＜ 0.001),however,the consistency was well (r=0.766,P=0.000).Logistic analysis showed that the detection rate of macular lesions was related to retinal folds,cysts in retina and CFT (r=1.396,1.041,0.12;P＜0.01).Conclusion CDFI can effectively detect macular lesions that affect the visual prognosis of senile cataract patients.

Objective To investigate the correlation between quantitative parameters derived from iodine overlay images and the monochromatic images of dual‐energy CT and the differentiation degree of laryngeal and hypopharyngeal squamous cell carcinoma(LHSCC). Methods Retrospective analysis of clinical and imaging data of eighty patients with different differentiation degree of LHSCC who underwent dual‐energy CT enhanced scan in the arterial and venous phase from March 2016 to January 2017 (20, 42 and 18 patients with well, moderately and poorly differentiation, respectively) was performed.Among them, twenty‐eight cases were stage T1, twenty‐four cases were stage T2, twenty cases were stage T3 and eight cases were stage T4. All patients were not treated with radiotherapy and chemotherapy before operation. Iodine overlay images and the monochromatic images of arterial and venous phases were acquired from Syngo MultiModality Workplace dual‐energy post‐processing software of Siemens, respectively. The mean iodine concentration (IC), standardized iodine concentration (SIC), and the slope of spectral curve(λ) of different differentiation degrees of LHSCC were calculated and compared. The correlation between quantitative parameters of LHSCC and its differentiation degree was performed by Spearman rank sum test. One‐way analysis of variance was used to compare the quantitative parameters of different differentiation degree of LHSCC. Receiver operating characteristic (ROC) curve was used for analyzing diagnostic efficiency. Results The IC, SIC, and λ in the arterial phase, and IC in the venous phase correlated positively with differentiation degree in LHSCC (r=0.258, 0.350, 0.262 and 0.275, respectively; P<0.05) in this group. The IC, SIC, and λ of poorly differentiated LHSCC in the arterial phase [(3.13 ± 0.54) mg/ml, (0.38±0.10), (5.40±0.92)] were higher than those of well differentiated LHSCC [(2.38±1.02) mg/ml, (0.25± 0.09) and (4.19 ± 1.18); t=2.73, 3.36 and 2.75 respectively; P<0.05] and moderately differentiated LHSCC [(2.56±0.85) mg/ml, (0.28±0.16) and (4.56±1.41); t=2.38, 3.06 and 2.21, P<0.05]. IC of poorly differentiated LHSCC in the venous phase [(2.59 ± 0.62) mg/ml] was significantly higher than that of well differentiated LHSCC [(1.96±0.56) mg/ml,t=2.45,P<0.05] and moderately differentiated [(2.02±0.93) mg/ml,t=2.56,P<0.05] LHSCC. There was no significant difference in the SIC and λ between different differentiation degrees of LHSCC (P>0.05) in the venous phase. The standardized iodine concentration in the arterial phase was the best in distinguishing poorly and moderately differentiated LHSCC, and poorly and well differentiated LHSCC with the area under the receiver operating curve 0.77 and 0.81, respectively, the sensitivity 88.2% and 70.0%, respectively, and the specificity 69.0% and 70.0%, respectively. Conclusions Quantitative parameters derived from dual‐energy CT might be useful in the evaluation of different differentiated degrees of LHSCC. In addition, the standardized iodine concentration of LHSCC in the arterial phase was the best in the estimation of different differentiated degrees of LHSCC.

Objective To investigate clinical efficacy of hyperbaric oxygen (HBO) combined with cilostazole in the treatment of the patients with diabetic foot and its impact on the level of serum insulin-like growth factor-1 (IGF-1).Methods One hundred patients with diabetic foot who were admitted into the Department of Endocrinology of the Shanxi Integrated Hospital of Traditional Chinese and Western Medicine from August 2016 to February 2018,were recruited as research subjects.The patients were randomly divided into the observation group (or the HBO + cilostazol group) and the control group (or the simple cilostazol group),each consisting of 50 patients.After 3 courses of treatment,the clinical efficacy,hemorheological parameters,peripheral nerve conduction velocity and the expression level of serum IGF-1 were compared between the 2 groups.Results After 3 courses of treatment,the total efficacy rate of the observation group (82.0％) was obviously higher than that of the control group (60.0％),and statistical significance could be seen when comparisons were made between them (P ＜ 0.01).The plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,fibrinogen,erythrocyte aggregation index and erythrocyte specific volume of the observation group were significantly lower than those of the control group,with statistical significance (P ＜ 0.05).The median nerve conduction velocity,ulnar nerve conduction velocity and peroneal nerve conduction velocity of the 2 groups all significantly increased,and the levels of the observation group were significantly higher than those of the control group,also with statistical significance (P ＜ 0.05 or P ＜ 0.01).The levels of serum IGF-1 in both groups significantly elevated,as compared with those before treatment,and the serum IGF-1 level in the observation group [(98.38 ± 20.83) mg/L] after treatment was significantly higher than that in the control group [(64.48 ± 22.92) mg/L],also with statistical significance (P ＜ 0.05 orP＜0.0l).Conclusion HBO combined with cilostazol could effectively reduce blood viscosity,improve blood circulation,increase peripheral nerve conduction velocity and regulate the expression level of serum IGF-1 in patients with DF.Therefore,it would have good prognosis for further improvement of diabetic microangiopathy.