Kawasaki disease（KD）is a non-specific inflammation of small and medium-sized arteries in children.Some of these cases are accompanied by coronary artery damage，which has become one of the main causes of acquired heart disease in children in recent years.However，up to now，the molecular mechanism of mediating pathological changes of KD has not been fully understood at home and abroad.Therefore，the establishment of an animal model which is highly similar to the clinical pathological changes to make up for the scarcity of clinical samples is of great significance for the future study of the pathogenesis of KD.At present，KD mouse models inducers include Lactobacillus casei cell wall extract，Candida albicans water-soluble polysaccharide fragments，Candida albicans derivatives，and so on.This paper introduces the KD mouse models established by the above-mentioned inducers and the KD coronary artery damage models induced by serum or other causes in rabbits，young pigs and dogs.The related pathways and inflammatory factors involved may provide new ideas for early clinical diagnosis and targeted drug therapy of KD.

Objective:To investigate the efficacy and adverse reactions of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) combined with chemotherapy in the treatment of superior mediastinal lymph node metastasis after esophageal cancer surgery.Methods:The clinical data of 72 patients with concurrent chemoradiotherapy for superior mediastinal lymph node metastasis after esophageal cancer surgery in Tai'an Cancer Prevention and Treatment Hospital from January 2019 to May 2021 were retrospectively analyzed, and they were divided into intensity-modulated radiotherapy (IMRT) group (36 cases) and SIB-IMRT group (36 cases) according to different radiotherapy methods. The short-term efficacy, long-term survival rate and adverse reactions of the two groups were compared.Results:The response rate in the IMRT group was 66.7% (24/36), the response rate in the SIB-IMRT group was 86.1% (31/36), and the difference between the two groups was statistically significant ( χ2 = 3.77, P = 0.047). The 1-, 2- and 3-year overall survival rates in the IMRT group were 75.0%, 44.4% and 27.8%, and the 1-, 2- and 3-year overall survival rates in the SIB-IMRT group were 83.3%, 52.8% and 33.3%; the difference in the overall survival between the two groups was not statistically significant ( χ2 = 0.70, P = 0.401). There were statistical differences in the incidence of leukopenia, radiation esophagitis and radiation pleural gastritis between the two groups (all P < 0.05). There were no statistical differences in the incidence of radiation pneumonia and gastrointestinal reactions between the two groups (both P > 0.05). Conclusions:SIB-IMRT combined with chemotherapy in patients with superior mediastinal lymph node metastasis after esophageal cancer surgery has good local control rate and mild adverse reactions.