Objective By applying the long short-term memory(LSTM)neural network model and using lower body landmark coordinates obtained from a markerless motion capture system as inputs,to estimate ground reaction force(GRF)curves during running.Methods The video images and GRF data of 59 amateur runners during running were collected by the markerless motion capture system and three-dimensional(3D)force plates.The LSTM model was established,and the 3D coordinates of 11 lower body landmarks,obtained via the Theia3D markerless system,were used as inputs to estimate the 3D GRF curves during the stance of running.The estimation performance was evaluated using correlation coefficients r,root mean square error(RMSE),and normalized root mean square error(nRMSE)by comparing LSTM model estimation and force plate measurement.Statistical parametric mapping was used to analyze differences in GRF curves estimated by the LSTM model and measured by the force plate,while paired t-tests were used to assess differences in GRF characteristics between model estimation and actual measurement.Results A strong correlation(r＞0.85,P＜0.001)and lower error(RMSE＜0.3 body weight,nRMSE＜15％)was found between the LSTM model estimation and actual measurements.No significant difference was found in GRF curve intervals between LSTM model estimation and actual measurements.There was no significant difference in GRF characteristics between LSTM model estimation and actual measurements(P＞0.05).Conclusions Based on the LSTM model,the 3D GRF curves can be effectively estimated by lower body landmark coordinates obtained from the makerless motion capture system,thereby acquiring the highly accurate GRF characteristics.The LSTM model developed in this study can be used to monitor injury risks during running in outdoor environments.

Objective This study aimed to adapt the data-driven Palliative Care Outcomes Collaboration(PCOC)model to the local context and evaluate its feasibility and preliminary effectiveness in a palliative care unit in China,with the goal of informing its broader integration into national palliative care practice.Methods Based on international experience,a localized implementation protocol for the PCOC model was developed through expert con-sultations and a pilot study.The protocol incorporated key elements including organizational and managerial sup-port,team training and capacity building,information system integration,supervision and feedback mechanisms,pro-cess optimization,and data-driven decision-making.From June to December 2023,the protocol was piloted in the palliative care unit of a tertiary cancer hospital in Changsha,China.Implementation outcomes were assessed by comparing patients' urgent care response rates,symptom stability rates,and symptom improvement rates between the first 1～3 months and 4～6 months after implementation.Results During the study period,a total of 355 inpatients were enrolled,with the PCOC assessment achieving full coverage(100％)and a completion rate of 97.78％.There was no statistically significant difference in the urgent needs response rate between the first 1～3 months and the 4～6 months after the implementation of the PCOC model(P=0.533).However,compared to the first 1～3 months af-ter implementation,patients in the 4～6 months period showed significantly higher symptom stability rates for pain,psychological/spiritual issues,and family/caregiver problems,as well as a higher improvement rate for pain(P＜0.05).Conclusion The localized PCOC implementation protocol facilitates standardized assessment and symptom manage-ment,and its application can enhance the quality of palliative care.

Objective:To observe the effects of shallow needling at Baihui(GV20)on neurological function and cerebral hemodynamics in patients with poststroke depression(PSD).Methods:A total of 90 PSD patients were divided into a Western medication group and a shallow needling group using the random number table,with 45 cases in each group.The Western medication group was treated with oral paroxetine tablets.The shallow needling group was treated with shallow needling at Baihui(GV20).The treatment course for both groups was 4 weeks.After treatment,the clinical efficacy was compared between the two groups.The scores of Hamilton depression scale-24(HAMD-24)and National Institutes of Health stroke scale(NIHSS),the cerebral hemodynamic changes,and the adverse reactions were observed.Results:After treatment,the total effective rate was 88.9%in the Western medication group and 84.4%in the shallow needling group;the difference between the two groups was not statistically significant(P>0.05).After treatment,the scores of HAMD-24 and NIHSS in both groups decreased(P<0.05).The difference in the HAMD-24 score between the two groups was not statistically significant(P>0.05).The NIHSS score in the shallow needling group was lower than that in the Western medication group,and the difference between the two groups was statistically significant(P<0.05).After treatment,there were no significant differences in the blood flow resistance index of the left middle cerebral artery(LMCA),right middle cerebral artery(RMCA),and basilar artery(BA)in the Western medication group compared to those before treatment.The blood flow resistance index of LMCA,RMCA,and BA in the shallow needling group was lower than that before treatment(P<0.05),and was significantly lower compared to the Western medication group(P<0.05).The incidence of adverse reactions in the shallow needling group was significantly lower than that in the Western medication group(P<0.05).Conclusion:The curative effect of shallow needling at Baihui(GV20)in the treatment of PSD is equivalent to that of oral paroxetine tablets.However,shallow needling at Baihui(GV20)is more effective in improving neurological function and cerebral perfusion,and the incidence of adverse reactions is lower.

Objective By applying the long short-term memory(LSTM)neural network model and using lower body landmark coordinates obtained from a markerless motion capture system as inputs,to estimate ground reaction force(GRF)curves during running.Methods The video images and GRF data of 59 amateur runners during running were collected by the markerless motion capture system and three-dimensional(3D)force plates.The LSTM model was established,and the 3D coordinates of 11 lower body landmarks,obtained via the Theia3D markerless system,were used as inputs to estimate the 3D GRF curves during the stance of running.The estimation performance was evaluated using correlation coefficients r,root mean square error(RMSE),and normalized root mean square error(nRMSE)by comparing LSTM model estimation and force plate measurement.Statistical parametric mapping was used to analyze differences in GRF curves estimated by the LSTM model and measured by the force plate,while paired t-tests were used to assess differences in GRF characteristics between model estimation and actual measurement.Results A strong correlation(r＞0.85,P＜0.001)and lower error(RMSE＜0.3 body weight,nRMSE＜15％)was found between the LSTM model estimation and actual measurements.No significant difference was found in GRF curve intervals between LSTM model estimation and actual measurements.There was no significant difference in GRF characteristics between LSTM model estimation and actual measurements(P＞0.05).Conclusions Based on the LSTM model,the 3D GRF curves can be effectively estimated by lower body landmark coordinates obtained from the makerless motion capture system,thereby acquiring the highly accurate GRF characteristics.The LSTM model developed in this study can be used to monitor injury risks during running in outdoor environments.

Objective This study aimed to adapt the data-driven Palliative Care Outcomes Collaboration(PCOC)model to the local context and evaluate its feasibility and preliminary effectiveness in a palliative care unit in China,with the goal of informing its broader integration into national palliative care practice.Methods Based on international experience,a localized implementation protocol for the PCOC model was developed through expert con-sultations and a pilot study.The protocol incorporated key elements including organizational and managerial sup-port,team training and capacity building,information system integration,supervision and feedback mechanisms,pro-cess optimization,and data-driven decision-making.From June to December 2023,the protocol was piloted in the palliative care unit of a tertiary cancer hospital in Changsha,China.Implementation outcomes were assessed by comparing patients' urgent care response rates,symptom stability rates,and symptom improvement rates between the first 1～3 months and 4～6 months after implementation.Results During the study period,a total of 355 inpatients were enrolled,with the PCOC assessment achieving full coverage(100％)and a completion rate of 97.78％.There was no statistically significant difference in the urgent needs response rate between the first 1～3 months and the 4～6 months after the implementation of the PCOC model(P=0.533).However,compared to the first 1～3 months af-ter implementation,patients in the 4～6 months period showed significantly higher symptom stability rates for pain,psychological/spiritual issues,and family/caregiver problems,as well as a higher improvement rate for pain(P＜0.05).Conclusion The localized PCOC implementation protocol facilitates standardized assessment and symptom manage-ment,and its application can enhance the quality of palliative care.

Objective:To observe the effects of shallow needling at Baihui(GV20)on neurological function and cerebral hemodynamics in patients with poststroke depression(PSD).Methods:A total of 90 PSD patients were divided into a Western medication group and a shallow needling group using the random number table,with 45 cases in each group.The Western medication group was treated with oral paroxetine tablets.The shallow needling group was treated with shallow needling at Baihui(GV20).The treatment course for both groups was 4 weeks.After treatment,the clinical efficacy was compared between the two groups.The scores of Hamilton depression scale-24(HAMD-24)and National Institutes of Health stroke scale(NIHSS),the cerebral hemodynamic changes,and the adverse reactions were observed.Results:After treatment,the total effective rate was 88.9%in the Western medication group and 84.4%in the shallow needling group;the difference between the two groups was not statistically significant(P>0.05).After treatment,the scores of HAMD-24 and NIHSS in both groups decreased(P<0.05).The difference in the HAMD-24 score between the two groups was not statistically significant(P>0.05).The NIHSS score in the shallow needling group was lower than that in the Western medication group,and the difference between the two groups was statistically significant(P<0.05).After treatment,there were no significant differences in the blood flow resistance index of the left middle cerebral artery(LMCA),right middle cerebral artery(RMCA),and basilar artery(BA)in the Western medication group compared to those before treatment.The blood flow resistance index of LMCA,RMCA,and BA in the shallow needling group was lower than that before treatment(P<0.05),and was significantly lower compared to the Western medication group(P<0.05).The incidence of adverse reactions in the shallow needling group was significantly lower than that in the Western medication group(P<0.05).Conclusion:The curative effect of shallow needling at Baihui(GV20)in the treatment of PSD is equivalent to that of oral paroxetine tablets.However,shallow needling at Baihui(GV20)is more effective in improving neurological function and cerebral perfusion,and the incidence of adverse reactions is lower.

Background:Intestinal Beh?et's disease is a subtype of multisystem vasculitis that affects the intestine,leading to severe intestinal and extra-intestinal complications,increased hospitalization rate,and a decrease in the quality of life of patients.Aims:To analyze the clinical,endoscopic,and pathological characteristics of patients with intestinal Beh?et's disease.Methods:Twenty-five patients with intestinal Beh?et's disease admitted from April 2018 to April 2023 at Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology were enrolled.The demographic data,clinical symptoms and signs,endoscopic findings,laboratory results,and therapeutic strategies were retrospectively analyzed.Results:In 25 patients with intestinal Beh?et's disease enrolled in this study,12 were males and 13 females,with a median age of onset at 37 years old.Oral ulcer was reported in 72.0%of patients,with 60.0%presenting with oral ulcer as the initial manifestation.Before diagnosis,60.0%of patients suffered from abdominal pain,and 12.0%experienced retrosternal pain or discomfort.All patients presented with ileocecal ulcer under endoscopy,with 15 cases of typical ulcer and 10 cases of atypical ulcer.The difference in gender distribution was statistically significant between the two groups(P=0.041 4).The disease activity index for intestinal Beh?et's disease(DAIBD)in typical ulcer group was significantly higher than that in atypical ulcer group(P=0.019 4),while no significant differences in neutrophil count,hemoglobin,hypersensitive C-reactive protein,and γ-glutamyl transferase were found between the two groups(P>0.05).Five patients were accompanied with esophageal ulcer.During the course of the disease,5 patients escalated to biological therapy(adalimumab or infliximab).Four patients with typical ulcer underwent surgical treatment due to complications such as intestinal perforation,gastrointestinal bleeding,and anal fistula.Conclusions:There exists a significant association between gender,DAIBD score and typical ileocecal ulcer in patients with intestinal Beh?et's disease.

Objective This paper aims to investigate and analyze the baseline conformity rate of bacterial culture exami-nation records in a tertiary specialized hospital.By doing this,this paper seeks to understand the current situation of medical re-cord writing of bacterial culture examination and explore the improvement path and relevant measures for enhancing the conformity rate of bacterial culture examination records.Methods According to the requirements of"Quality Control Index of Medical Re-cord Management(2021 Edition)",a retrospective analysis was conducted on 6 317 medical records that underwent bacterial culture examination in 2022.Results The execution rate of medical orders was 100.00％,the completeness rate of the report sheet was 100.00％,the record rate of medical records was 81.05％,the analysis rate of results was 33.07％,and the conformi-ty rate of bacterial culture examination records was 33.07％.Conclusion It is imperative to enhance the conformity rate of bac-terial culture examination records and improve the quality of medical records in terms of content.

Objective To explore the value of conventional and contrast‐enhanced ultrasound(CEUS) in the diagnosis of tumors in front of the orbit equator . Methods Clinical data included conventional ultrasound and CEUS image of 133 cases (156 eyes) with orbital lesions were analyzed retrospectively . All lesions were confirmed by surgical pathology or clinical cure ,which included 26 cases of cystic lesions (epidermoid cysts ,dermoid cysts ,sebaceous cysts and mucous cysts) ,29 cases (30 eyes) of orbital hemangioma ,13 cases ( 16 eyes ) of inflammatory pseudotumor ,11 cases of lacrimal gland pleomorphic adenoma ,3 cases (5 eyes) of lymphoepithelial lesion ,36 cases (53 eyes) of malignant lymphoma ,5 cases of meibomian gland carcinoma ,4 cases of lacrimal gland adenoid cystic carcinoma ,3 cases of malignant melanoma and 3 cases of basal cell carcinoma . Results CEUS of benign cystic lesions showed the tumors were enhanced inhomogenously . Most CEUS of benign tumours displayed?slow in and slow out ,and high enhancement when reached the peak but the size of images had no change . While CEUS of malignant tumours showed?fast in and fast out ,homogeneous or inhomogeneous high enhancement and ill‐defined or irregular shape ,and volume increased compared to two‐dimensional ultrasound when reached the peak .Some other former district orbital lesions ,such as cystic lesion ,cavernous hemangioma ,pleomorphic adenoma and malignant lymphoma ,had their own ultrasound features . Conclusions CEUS combines with conventional ultrasound may contribute to the qualitative diagnosis of tumors in front of the orbit equator .

Objective To study the effects of different levels of hemodilution during extracorporeal circulation(ECC) on the concentration of lactic acid and postoperative outcome in children with congenital heart disease.Methods Sixty children with congenital heart diseases undergoing open heart surgery with ECC were randomly divided into three groups: groupⅠ(n=20) underwent mild hemodilution [Hb(80—90)g/L],groupⅡ(n=20) with medium hemodilution [Hb(70—79)g/L],and groupⅢ(n=20) with deep hemodilution [Hb(60—69)g/L].The concentration of lactic acid and PaO_2 in groupⅡ and group Ⅲ were compared with groupⅠ before ECC,during ECC,after ECC and 24h after the operation.The rate of homologous transfusion during ECC and the postoperative dosage of furosemide were also compared among the three groups.Results The concentrations of lactic acid and PaO2 in the three groups were all within normal range before ECC,during ECC,after ECC and 24h after operation.The homologous transfusion rate during ECC were lower in groupⅡ(30%)and groupⅢ(15%) compared to that of groupⅠ(50%)(P