Objective To investigate the clinical efficacy of Yiqi Huoxue Prescription(derived from Shengyu Decoction)in the treatment of mild cervical spondylotic myelopathy(CSM)with qi deficiency and blood stasis type.Methods A total of 128 patients with mild CSM of qi deficiency and blood stasis type who admitted to Guangdong Provincial Hospital of Chinese Medicine from January 2022 to January 2024 were randomly divided into the control group and the trial group according to the random number table method,with 64 cases in each group.The control group was treated with oral administration of Mecobalamin Tablets,and the trial group was treated with Yiqi Huoxue Prescription orally on the basis of treatment for the control group.The two groups were all treated for four weeks,and then were followed up for three months after the completion of treatment.The CSM scores of the Japanese Orthopedic Association(JOA)and the traditional Chinese medicine(TCM)syndrome scores in the two groups were observed before treatment,after two weeks of treatment,after four weeks of treatment,and three months after the completion of treatment.And then the clinical efficacy,progression of CSM and the incidence of adverse reactions of the two groups were evaluated.Results(1)During the trial,two cases in the control group and three cases in the trial group fell off,and eventually a total of 123 cases were included,62 cases in the control group and 61 cases in the trial group.(2)Three months after the completion of treatment,the total effective rate of the trial group was 93.44%(57/61)and that of the control group was 82.26%(51/62),and the intergroup comparison(tested by chi-square test)showed that the efficacy of the trial group was significantly superior to that of the control group,the difference being statistically significant(P<0.05).(3)After two and four weeks of treatment as well as three months after the completion of treatment,JOA scores in the two groups were increased compared with those before treatment(P<0.05),and JOA scores of the trial group at various time points mentioned above were higher than those of the control group,the difference being statistically significant(P<0.05).(4)After two and four weeks of treatment as well as three months after the completion of treatment,TCM syndrome scores in the two groups were decreased compared with those before treatment(P<0.05),and TCM syndrome scores of the trial group at various time points mentioned above were lower than those of the control group,the difference being statistically significant(P<0.05).(5)During the follow-up period,there was none case of significant aggravation or progression to moderate-severe illness in the two groups,and there were no adverse events such as allergies and gastrointestinal reactions.Conclusion Yiqi Huoxue Prescription exerts certain efficacy in treating patients with mild CSM of the qi deficiency and blood stasis type,and the treatment method is effective on improving the spinal cord function and symptoms of qi deficiency and blood stasis type,and slowing down the progression of disease in the patients,with high safety.

Objective To evaluate the efficacy of four-dimensional traction in elderly patients with degenera-tive lumbar spinal stenosis(DLSS),focusing on changes in lumbar muscle morphology and mechanical properties.Methods Elderly patients with DLSS admitted to the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2022 to February 2024 were enrolled.Based on the treatment method,they were categorized into the study group(muscle exercise combined with four-dimensional traction,n=40)and the control group(routine muscle exercise,n=40).All participants underwent a 4-week treatment regimen and subsequently received multimodal ultrasound examinations.The morphology and mechanical properties of the lumbar muscle group,lumbar range of motion,walking distance in intermittent claudication,Visual Analogue Scale(VAS),and Oswestry Disability Index(ODI)scores were compared between the two groups.Results After treatment,the study group exhibited significantly greater improvements in multifidus muscle thickness,circumference,cross-sectional area,pressure pain threshold,and lumbar range of motion(P<0.05).In contrast,the shear wave velocity(SWV),Young's modulus,muscle tension,and flexion-extension ratio of the multifidus muscle were significantly lower in the study group(P<0.05).Additionally,the walking distance in intermittent claudication for the study group was markedly longer(P<0.05).During the 12-month follow-up period after treatment,the VAS and ODI scores of the study group remained significantly lower(P<0.05).Conclusion Four-dimensional traction in combination with muscle exercise can effectively alleviate clinical symptoms,enhance muscle function,and improve mechanical properties in elderly patients with DLSS.

Objective To evaluate the efficacy of four-dimensional traction in elderly patients with degenera-tive lumbar spinal stenosis(DLSS),focusing on changes in lumbar muscle morphology and mechanical properties.Methods Elderly patients with DLSS admitted to the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2022 to February 2024 were enrolled.Based on the treatment method,they were categorized into the study group(muscle exercise combined with four-dimensional traction,n=40)and the control group(routine muscle exercise,n=40).All participants underwent a 4-week treatment regimen and subsequently received multimodal ultrasound examinations.The morphology and mechanical properties of the lumbar muscle group,lumbar range of motion,walking distance in intermittent claudication,Visual Analogue Scale(VAS),and Oswestry Disability Index(ODI)scores were compared between the two groups.Results After treatment,the study group exhibited significantly greater improvements in multifidus muscle thickness,circumference,cross-sectional area,pressure pain threshold,and lumbar range of motion(P<0.05).In contrast,the shear wave velocity(SWV),Young's modulus,muscle tension,and flexion-extension ratio of the multifidus muscle were significantly lower in the study group(P<0.05).Additionally,the walking distance in intermittent claudication for the study group was markedly longer(P<0.05).During the 12-month follow-up period after treatment,the VAS and ODI scores of the study group remained significantly lower(P<0.05).Conclusion Four-dimensional traction in combination with muscle exercise can effectively alleviate clinical symptoms,enhance muscle function,and improve mechanical properties in elderly patients with DLSS.

The precise localization of pulmonary nodules has become an important technical key point in the treatment of pulmonary nodules by thoracoscopic surgery, which is a guarantee for safe margin and avoiding removal of too much normal lung parenchyma. With the development of medical technology and equipment, the methods of locating pulmonary nodules are also becoming less trauma and convenience. There are currently a number of methods applied to the preoperative or intraoperative localization of pulmonary nodules, including preoperative percutaneous puncture localization, preoperative transbronchial localization, intraoperative palpation localization, intraoperative ultrasound localization, and localization according to anatomy. The most appropriate localization method should be selected according to the location of the nodule, available equipment, and surgeon鈥檚 experience. According to the published literatures, we have sorted out a variety of different theories and methods of localization of pulmonary nodules in this article, summarizing their advantages and disadvantages for references.

Data analysis models may assist the transmission of traditional Chinese medicine （TCM） experience and clinical diagnosis and treatment， and the possibility of constructing a “data-knowledge” dual-drive model was explored by taking gastric precancerous state as an example. Data-driven is to make clinical decisions around data analysis， and its syndrome-differentiation decision-making research relies on hidden structural models and partially observable Markov decision-making processes to identify the etiology of diseases， syndrome elements， evolution of pathogenesis， and syndrome differentiation protocols； knowledge-driven is to make use of data and information to promote decision-making and action processes， and its syndrome-differentiation decision-making research relies on convolutional neural networks to improve the accuracy of local disease identification and syndrome differentiation. The “data-knowledge” dual-driven model can make up for the shortcomings of single-drive numerical simulation accuracy， and achieve a balance between local disease identification and macroscopic syndrome differentiation. On the basis of previous research， we explored the construction method of diagnostic assisted decision-making platform for gastric precancerous state， and believed that the diagnostic and decision-making ability of doctors can be extended through the assistance of machines and algorithms. Meanwhile， the related research methods were integrated and the core features of gastric precancerous state based on TCM syndrome differentiation and endoscopic pathology diagnosis and prediction were obtained， and the elements of endoscopic pathology recognition based on TCM syndrome differentiation were explored， so as to provide ideas for the in-depth research and innovative application of cutting-edge data analysis technology in the field of intelligent TCM syndrome differentiation.

Objective To investigate the comparative effect of different spinal traction therapy on the treat-ment of degenerative lumbar spondylolisthesis based on the change of lumbosacral and pelvic sagittal position parameters.Methods The clinical data of 108 patients with degenerative lumbar spondylolisthesis admitted to Guangdong Provincial Hospital of Traditional Chinese Medicine from March 2022 to January 2024 were selected for retrospective analysis,and they were divided into the three-dimensional group(n=55)and the four-dimensional group(n=53)according to the difference in treatment methods.The four dimensional group received four dimen-sional traction combined with basic treatment,and the three dimensional group received three dimensional traction combined with basic treatment.Lumbosacral pelvis sagittal position parameters,vertebral glide reduction degree,lumbar curvature value,coronal Cobb Angle of lumbar spine,lumbar function,pain degree and clinical efficacy were compared between the two groups.Results At the end of treatment and 3 months after treatment,the levels of sacral inclination Angle(SS)and lumbar lordosis Angle(LL)in 3D and 4D groups were lower than before treat-ment,and at 3 months after treatment were lower than at the end of treatment(P＜0.05).At the end of treatment,SS and LL levels in 3D group were lower than those in 4D group(P＜0.05),while there was no difference in SS and LL levels between the two groups at 3 months after treatment(P＞0.05).The lumbar lordotic index and coro-nal Cobb Angle of both groups were lower than before treatment(P＜0.05),and at 3 months after treatment,the lumbar lordotic index and coronal Cobb Angle of both groups were lower than at the end of treatment(P＜0.05).At the end of treatment,the lumbar protrusion index and coronal Cobb Angle in the three-dimensional group were lower than those in the four-dimensional group(P＜0.05).At the end of treatment and 3 months after treatment,the distance of lumbar arch top in both groups was higher than before treatment(P＜0.05),and at 3 months after treatment,the distance of lumbar arch top in both groups was higher than at the end of treatment(P＜0.05).At the end of treatment,the distance of lumbar arch in the three-dimensional group was higher than that in the four-dimensional group(P＜0.05).At 3 months after treatment,there were no significant differences in lumbar lordo-sis index,coronal Cobb Angle of lumbar spine and distance between the two groups(P＞0.05).At the end of treatment and 3 months after treatment,visual analogue pain scale(VAS)scores in both groups were lower than before treatment(P＜0.05),and at 3 months after treatment,VAS scores in both groups were lower than at the end of treatment(P＜0.05).At the end of treatment and 3 months after treatment,the Japanese Orthopaedic Asso-ciation evaluated treatment score(JOA)in both groups was higher than that before treatment(P＜0.05),and at 3 months after treatment,the JOA score in both groups was higher than that at the end of treatment(P＜0.05).At the end of treatment and 3 months after treatment,there was no significant difference in JOA score and VAS score between the two groups(P＞0.05).At the end of treatment and 3 months after treatment,there was no difference in the reduction rate of vertebral slippage between the two groups(P＞0.05).There was no difference in total effec-tive rate between the two groups(P＞0.05).Conclusion Four dimensional traction and three dimensional traction combined with basic treatment of degenerative lumbar spondylolisthesis have the same efficacy,both can effectively reduce pain and improve lumbar function,but three dimensional traction is better in improving lumbar function and lumbosacral pelvic sagittal position parameters,and correcting lumbar curvature abnormalities.

Objective To investigate the comparative effect of different spinal traction therapy on the treat-ment of degenerative lumbar spondylolisthesis based on the change of lumbosacral and pelvic sagittal position parameters.Methods The clinical data of 108 patients with degenerative lumbar spondylolisthesis admitted to Guangdong Provincial Hospital of Traditional Chinese Medicine from March 2022 to January 2024 were selected for retrospective analysis,and they were divided into the three-dimensional group(n=55)and the four-dimensional group(n=53)according to the difference in treatment methods.The four dimensional group received four dimen-sional traction combined with basic treatment,and the three dimensional group received three dimensional traction combined with basic treatment.Lumbosacral pelvis sagittal position parameters,vertebral glide reduction degree,lumbar curvature value,coronal Cobb Angle of lumbar spine,lumbar function,pain degree and clinical efficacy were compared between the two groups.Results At the end of treatment and 3 months after treatment,the levels of sacral inclination Angle(SS)and lumbar lordosis Angle(LL)in 3D and 4D groups were lower than before treat-ment,and at 3 months after treatment were lower than at the end of treatment(P＜0.05).At the end of treatment,SS and LL levels in 3D group were lower than those in 4D group(P＜0.05),while there was no difference in SS and LL levels between the two groups at 3 months after treatment(P＞0.05).The lumbar lordotic index and coro-nal Cobb Angle of both groups were lower than before treatment(P＜0.05),and at 3 months after treatment,the lumbar lordotic index and coronal Cobb Angle of both groups were lower than at the end of treatment(P＜0.05).At the end of treatment,the lumbar protrusion index and coronal Cobb Angle in the three-dimensional group were lower than those in the four-dimensional group(P＜0.05).At the end of treatment and 3 months after treatment,the distance of lumbar arch top in both groups was higher than before treatment(P＜0.05),and at 3 months after treatment,the distance of lumbar arch top in both groups was higher than at the end of treatment(P＜0.05).At the end of treatment,the distance of lumbar arch in the three-dimensional group was higher than that in the four-dimensional group(P＜0.05).At 3 months after treatment,there were no significant differences in lumbar lordo-sis index,coronal Cobb Angle of lumbar spine and distance between the two groups(P＞0.05).At the end of treatment and 3 months after treatment,visual analogue pain scale(VAS)scores in both groups were lower than before treatment(P＜0.05),and at 3 months after treatment,VAS scores in both groups were lower than at the end of treatment(P＜0.05).At the end of treatment and 3 months after treatment,the Japanese Orthopaedic Asso-ciation evaluated treatment score(JOA)in both groups was higher than that before treatment(P＜0.05),and at 3 months after treatment,the JOA score in both groups was higher than that at the end of treatment(P＜0.05).At the end of treatment and 3 months after treatment,there was no significant difference in JOA score and VAS score between the two groups(P＞0.05).At the end of treatment and 3 months after treatment,there was no difference in the reduction rate of vertebral slippage between the two groups(P＞0.05).There was no difference in total effec-tive rate between the two groups(P＞0.05).Conclusion Four dimensional traction and three dimensional traction combined with basic treatment of degenerative lumbar spondylolisthesis have the same efficacy,both can effectively reduce pain and improve lumbar function,but three dimensional traction is better in improving lumbar function and lumbosacral pelvic sagittal position parameters,and correcting lumbar curvature abnormalities.

Objective To investigate the difference of standard tangential field and multiple fileld radiotherapy in axillary lymph node after conserving surgery,to provide a reference for clinical treatment.Methods 20 cases of left breast cancer patients were selected,all patients underwent breast -conserving surgery,postoperative radiothera-py.All patients used standard radiotherapy wild tangent based and reverse -intensity modulated radiation therapy optimization.Armpit I,Ⅱ lymph nodes were used to calculate the extent of coverage of the original plan,target dose uniformity HI,dose conformal CI,dosimetric parameters were calculated.Results Under standard tangential field irradiation,I stand mean dose was (33.95 ±8.24)Gy,which was significantly higher than Ⅱ station (22.13 ± 6.67)Gy,and V50,V45,V40 were (22.45 ±6.32)%,(39.83 ±7.54)%,(49.65 ±8.31)%,which were higher than Ⅱ stand,I stand irradiation was significantly more,the differences were statistically significant (t =5.632,P =0.009;t =7.214,P =0.000;t =8.954,P =0.000;t =6.121,P =0.002).The whole breast irradiation armpit IMRT plan,19 patients (95.00%)reached 95% by volume APTV≥50Gy,coverage was better;but HI,CI were (1.11 ± 0.03),(1.36 ±0.07)respectively,which were significantly worse than the standard wild tangent,the differences were statistically significant (t =6.584,P =0.001;t =9.144,P =0.000).Under Hatano IMRT irradiation ipsilateral lung,heart suffered an average dose of (1 694.58 ±102.31)cGy,(645.54 ±74.44)cGy,which were significantly more than the standard tangential field irradiation,the differences were statistically significant (t =7.654,P =0.000;t =6.654,P =0.001).Conclusion Standard tangential field irradiation has poor coverage in Ⅱ axillary lymph node station,irradiation intensity modulated radiation has better coverage,but significantly increased the dose to normal tissues.

Objective To investigate the intervening effect of movable cupping on sub-health status. Methods Movable cupping was performed on bilateral bladder meridians and the Du meridian in 12 patients with sub-health status. The sub-health status rating scale score, the visual analogue pain intensity scale score, hemorheological parameters and immunoglobulins were observed before and after movable cupping.Results The sub-health status rating scale score, the visual analogue pain intensity scale score, whole blood viscosity 200 and plasma viscosity decreased after treatment compared with before in the patients, and there were statistically significant differences (P<0.05). Whole blood viscosity 1, whole blood viscosity 2 and whole blood viscosity 3 decreased and IgG, IgA and IgM increased after treatment compared with before in the patients, but there were no statistically significant differences (P>0.05). Conclusion Movable cupping has clinically a certain improving effect on bodily sub-health status.

Tepoxalin is a potent inhibitor of both the cyclooxygenase and lipoxygenase pathways of the arachidonic acid cascade, as well as a potent anti-inflammatory and control-pain (postoperation, arthritis et. al.) agent. The new method about the use of novel synthesis reagents and the first using ionic liquid as reactive solvent to synthesize tepoxalin were presented in this paper. The ionic liquid can be easily recycled and reused for several runs efficiently. The analgesic activity of tepoxalin was detected by acetic acid test on mice. The analysis of variance showed that oral administration of tepoxalin could significantly inhibit the number of writhing response within 1 hour and prolong the latent time in a dose dependent manner as compared with CMC control group (P < 0.05). At the same time, tepoxalin had the same analgesic activity as diclofenac sodium.