Objective:To explore effects of health education based on the information-motivation-behavioral skills (IMB) skills model on self-care ability and complication rate in patients with liver cirrhosis.Methods:Using the convenient sampling method, a total of 170 patients with liver cirrhosis who were admitted to Department of Infectious Diseases of the First People's Hospital of Hangzhou Lin'an District from September 2018 to September 2020 were selected as the research objects. According to the random number table method, the patients were divided into the control group and the observation group, with 85 cases in each group. The control group received routine health education intervention, while the observation group received health education intervention combined with the IMB skills model on the basis of the control group. Exercise of Self-Care Agency Scale (ESCA) score, The MOS 36-Item Short Form Survey (SF-36) and the incidence of complications were observed in the two groups.Results:After the intervention and the ESCA scores of the two groups were higher than those before the intervention, and that of the observation group was higher than the control group, and the differences were statistically significant ( P<0.05) . The scores of each dimension of SF-36 in the observation group were higher than those in the control group, and the differences were statistically significant ( P<0.05) . The incidence of complications in the observation group was 3.52% (3/85) , lower than 17.65% (15/85) in the control group, and the difference was statistically significant ( P<0.05) . Conclusions:Health education using the IMB skill model for patients with liver cirrhosis can improve self-care ability and quality of life and the complications are fewer, which is worthy of clinical promotion.