Patients with severe trauma require an extremely timely treatment and transfusion plays an irreplaceable role in the emergency treatment of such patients. An increasing number of evidence-based medicinal evidences and clinical practices suggest that patients with severe traumatic bleeding benefit from early transfusion of low-titer group O whole blood or hemostatic resuscitation with red blood cells, plasma and platelet of a balanced ratio. However, the current domestic mode of blood supply cannot fully meet the requirements of timely and effective blood transfusion for emergency treatment of patients with severe trauma in clinical practice. In order to solve the key problems in blood supply and blood transfusion strategies for emergency treatment of severe trauma, Branch of Clinical Transfusion Medicine of Chinese Medical Association, Group for Trauma Emergency Care and Multiple Injuries of Trauma Branch of Chinese Medical Association, Young Scholar Group of Disaster Medicine Branch of Chinese Medical Association organized domestic experts of blood transfusion medicine and trauma treatment to jointly formulate Chinese expert consensus on blood support mode and blood transfusion strategies for emergency treatment of severe trauma patients ( version 2024). Based on the evidence-based medical evidence and Delphi method of expert consultation and voting, 10 recommendations were put forward from two aspects of blood support mode and transfusion strategies, aiming to provide a reference for transfusion resuscitation in the emergency treatment of severe trauma and further improve the success rate of treatment of patients with severe trauma.

The muscle-fat ratio is a crucial indicator for assessing the balance between muscle and fat, which can be evaluated using methods such as bioelectrical impedance and dual-energy X-ray absorptiometry.In contrast to traditional obesity diagnoses that rely solely on body mass index or waist circumference, the muscle-fat ratio offers a more comprehensive overview of the body's condition.It is closely linked to various health risks, particularly metabolic and cardiovascular diseases.Sarcopenic obesity seeks to capture the risks associated with cardiometabolic diseases and functional decline, making the muscle-fat ratio particularly suitable for the early identification and diagnosis of patients with this condition.Furthermore, the muscle-fat ratio correlates with the prognosis of various diseases and the risk of adverse clinical outcomes.Consequently, its application extends beyond disease screening and diagnosis, serving as a vital foundation for guiding intervention measures.Given its broad application prospects, the muscle-fat ratio is poised to play an increasingly significant role in enhancing global population health, delaying the aging process, and preventing and treating related diseases.

The muscle-fat ratio is a crucial indicator for assessing the balance between muscle and fat, which can be evaluated using methods such as bioelectrical impedance and dual-energy X-ray absorptiometry.In contrast to traditional obesity diagnoses that rely solely on body mass index or waist circumference, the muscle-fat ratio offers a more comprehensive overview of the body's condition.It is closely linked to various health risks, particularly metabolic and cardiovascular diseases.Sarcopenic obesity seeks to capture the risks associated with cardiometabolic diseases and functional decline, making the muscle-fat ratio particularly suitable for the early identification and diagnosis of patients with this condition.Furthermore, the muscle-fat ratio correlates with the prognosis of various diseases and the risk of adverse clinical outcomes.Consequently, its application extends beyond disease screening and diagnosis, serving as a vital foundation for guiding intervention measures.Given its broad application prospects, the muscle-fat ratio is poised to play an increasingly significant role in enhancing global population health, delaying the aging process, and preventing and treating related diseases.

OBJECTIVE:To investigate the effect of edelfosine on the proliferation of Hela cells and its mechanism.METHODS:Hela cells were treated with edelfosine at doses of 0(control),0.5,1.0,5.0,10.0 ?mol?L-1 for 96 h.MTT assay,flow cytometry,and staining were performed to determine the cell proliferation activity,cell cycle,and apoptotic rate.RESULTS:As compared with control,the cell proliferation activity of Hela cells was inhibited in a dose-and time-dependent manner after being treated by edelfosine for 24～96 h.After being treated by edelfosine(1.0,5.0,10.0 ?mol?L-1) for 72 h,the number of Hela cells significantly increased in G0/G1 phase but decreased in S phase(P