Objective To investigate the status quo of self-regulated fatigue in patients with recurrent ovarian cancer,and analyze the correlation between self-perceived burden,social support level and self-regulated fatigue.Methods From January 2020 to January 2023,120 patients with recurrent ovarian cancer in Fujian Cancer Hospital were selected by convenient sampling method,and data were collected by self-made general information questionnaire,self-perceived burden scale,social support scale and self-regulated fatigue scale.Results The score of self-regulated fatigue in 120 patients with recurrent ovarian cancer was(57.39±8.88)points,which was positively correlated with the score of self-perceived burden(68.28±18.98)points(r=0.431,P＜0.05)and negatively correlated with the score of social support(31.32±10.28)points(r=-0.321,P＜0.05).The results show that self-perceived burden,social support,education level,per capita monthly average income and course of disease are independent factors affecting self-regulated fatigue in patients with recurrent ovarian cancer.Conclusion Self-regulated fatigue in patients with recurrent ovarian cancer is in the middle and high level,which is positively correlated with self-perceived burden and negatively correlated with social support level.Clinical nurses should take corresponding measures to reduce the degree of self-regulation fatigue in patients with recurrent ovarian cancer.