Thermal ablation, an established minimally invasive technique, is increasingly utilized in treating thyroid nodules and microthyroid papillary carcinoma.Compared to conventional surgery, it offers advantages including minimal trauma, rapid recovery, and fewer complications.Recent technological advances have revealed its potential for managing primary hyperthyroidism. This review examines current evidence on thermal ablation applications in hyperthyroidism, analyzes its efficacy and safety, and discusses future challenges to inform clinical practice and research.

Thermal ablation, an established minimally invasive technique, is increasingly utilized in treating thyroid nodules and microthyroid papillary carcinoma.Compared to conventional surgery, it offers advantages including minimal trauma, rapid recovery, and fewer complications.Recent technological advances have revealed its potential for managing primary hyperthyroidism. This review examines current evidence on thermal ablation applications in hyperthyroidism, analyzes its efficacy and safety, and discusses future challenges to inform clinical practice and research.

A system for achieving two-dimensional(2D)visualization and three-dimensional(3D)reconstruction of lung images using CT data is designed.After DICOM image processing,and lung nodule segmentation and labeling,the multi-view and multi-resolution 3D display of lung parenchyma and nodules is realized using techniques such as resampling of CT sequences,3D reconstruction based on surface rendering,and morphological processing.Finally,the interactive interface is designed for implementing the functions of image enhancement,2D visualization,nodule delineation,3D reconstructions of lung parenchyma and nodules,rotation,zooming and switching the viewpoint.Experimental results show that the system provides clear and accurate 2D image visualization and lesion delineation,while reconstructing nodules in the generated 3D images completely and smoothly.Compared with the existing similar medical processing software,the developed system substantially improves the reconstruction and visualization efficiencies,enabling doctors to observe 3D images more quickly and accurately,and assisting in disease diagnosis and surgical planning.

In recent years,the role of temporomandibular joint(TMJ)motion in overall health of the orofacial system has increasingly captured the attention in the fields of oral medicine and rehabilitation medicine.The quantitative analysis of TMJ kinematics is crucial for understanding and treating orofacial functional disorders.This review summarizes the advancements in electronic axiography,optical motion capture,and dual-fluoroscopy technologies in clinical and research applications over the past decade.Electronic axiography and optical motion capture technologies,known for their high precision and real-time feedback,have been widely utilized in analyzing TMJ motion characteristics,evaluating treatment outcomes,and optimizing therapeutic techniques.dual fluoroscopic imaging system tracking technique demonstrates high accuracy and repeatability in analyzing complex joint motions.Although these technologies still face challenges regarding operational complexity,data stability,and safety,ongoing developments in motion analysis techniques and in-depth studies of orofacial system functions are expected to significantly enhance the precision and personalization of diagnostics and treatments for orofacial system diseases in the future.

In recent years,the role of temporomandibular joint(TMJ)motion in overall health of the orofacial system has increasingly captured the attention in the fields of oral medicine and rehabilitation medicine.The quantitative analysis of TMJ kinematics is crucial for understanding and treating orofacial functional disorders.This review summarizes the advancements in electronic axiography,optical motion capture,and dual-fluoroscopy technologies in clinical and research applications over the past decade.Electronic axiography and optical motion capture technologies,known for their high precision and real-time feedback,have been widely utilized in analyzing TMJ motion characteristics,evaluating treatment outcomes,and optimizing therapeutic techniques.dual fluoroscopic imaging system tracking technique demonstrates high accuracy and repeatability in analyzing complex joint motions.Although these technologies still face challenges regarding operational complexity,data stability,and safety,ongoing developments in motion analysis techniques and in-depth studies of orofacial system functions are expected to significantly enhance the precision and personalization of diagnostics and treatments for orofacial system diseases in the future.

Objective:To investigate the correlations of endoscopic evaluation results with laboratory indices and clinical disease activity in Crohn disease (CD) patients with different intestinal involvement.Methods:Data of 147 patients diagnosed as having CD who visited the Department of Gastroenterology, Zhongnan Hospital of Wuhan University from July 1, 2017 to June 30, 2022 were collected retrospectively. According to the involvement of intestinal segment, patients were divided into three groups: the group with isolated small intestinal involvement ( n=55), the group with both small intestinal and large intestinal involvement ( n=48), and the group with isolated large intestinal involvement ( n=44). Correlations of endoscopic evaluation (based on CDEIS) with laboratory indices and clinical disease activity (based on Harvey-Bradshaw index) were analyzed. Results:C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) could be used for the prediction of endoscopic disease activity. The areas under curve (AUC) of receiver operator characteristic (ROC) were 0.677 (0.506-0.849) and 0.744 (0.597-0.890), respectively. In terms of determing clinical disease activity, clinical Harvey-Bradshaw index was consistent with endoscopic CDEIS score in 65.3% (96/147) patients, showing a low positive correlation ( r=0.260, P<0.05). In subgroup analysis for patients with isolated small intestinal involvement, CRP showed no predictive value for clinical disease activity [AUC (95% CI): 0.617 (0.461-0.773), P=0.148], while for endoscopic activity neither CRP nor ESR showed predictive value [AUC (95% CI): 0.537 (0.146-0.929), P=0.829; AUC (95% CI): 0.571 (0.153-0.990), P=0.680]. Furthermore, for patients with isolated small intestinal involvement and both small intestinal and large intestinal involvement, no correlation was found between clinical Harvey-Bradshaw index and endoscopic CDEIS score ( r=0.222, P=0.092; r=0.142, P=0.322). Conclusion:For CD patients with small intestinal involvement, especially isolated small intestinal involvement, laboratory indices and clinical disease activity cannot accurately reflect endoscopic disease activity. Great importance should be attached to evaluation of the extent and activity of intestinal lesions by endoscopy, especially enteroscopy.

Objective:To study the risk factors for complications after endoscopic retrograde cholangiopancreatography (ERCP) in super-aged patients (≥80 years).Methods:Clinical data of 512 super-aged patients with pancreaticobiliary diseases who underwent 638 ERCP procedures at the Digestive Endoscopy Center, Zhongnan Hospital of Wuhan University, from July 2011 to June 2021, were studied retrospectively. Indications and results of the ERCP operations were analyzed. Multivariate logistic regression model was used to analyze the risk factors for ERCP-related complications.Results:The total success rate of ERCP cannulation in super-aged patients was 94.0% (600/638), which showed no difference compared with that of patients of <60 years old (2 433/2 557, 95.2%) or patients of 60~<80 years old (2 815/3 004, 93.7%) ( χ2=5.49, P=0.064). The overall incidence of post-ERCP complications was 15.2% (97/638), and the in-hospital mortality was 2.1% (11/512), which showed significant difference compared with patients of <60 years old (8/1 809, 0.4%) and patients of 60-<80 years old (21/2 127, 1.0%) ( χ2=13.39, P=0.002). Multivariate regression analysis showed that hypertension ( HR=1.94, 95% CI: 1.237-3.041, P=0.004), history of upper gastrointestinal reconstruction ( HR=2.28, 95% CI: 1.064-4.891, P=0.034), endoscopic sphincterectomy ( HR=1.65, 95%CI: 1.012-2.679, P=0.045), early procedure period ( HR=0.57, 95% CI: 0.352-0.923, P=0.022), operation time >30 minutes ( HR=1.74, 95% CI: 1.094-2.759, P=0.019), preoperative white blood cell count >9.5×10 9/L ( HR=2.66, 95% CI: 1.661-4.257, P<0.001) and procalcitonin ≥0.05 ng/L ( HR=2.54, 95% CI: 1.172-5.513, P=0.018) were independent risk factors for post-ERCP complications. Conclusion:ERCP is safe and effective for super-aged patients. However, much attention should be paid to post-ERCP complications of patients with hypertension, history of upper gastrointestinal reconstruction, endoscopic sphincterectomy, operation time >30 minutes, preoperative white blood cell count >9.5×10 9/L and procalcitonin ≥0.05 ng/L to avoid serious adverse events such as mortality.

Objective To study and analyze the features and pattern of the common diseases occurred among recruits of a certain naval unit during training,so as to provide reference for the prevention of diseases.Methods Medical data files in the medical corps were sorted out,and were then classified according to the types of diseases,and finally were analyzed statistically.Results During recruit training,through outpatient service,inpatient service and medical tours or calls,there were 362 cases of various diseases,accounting for 22.3％ of all the recruits engaged in the recruit training.The top three diseases were:infection of the upper respiratory tract,with 128 cases,accounting for 7.88％,soft tissue injury of extremities with 68 cases,accounting for 4.18％ and oral diseases with 22 cases,accounting for 1.35％.From the perspective of diseases incidence,the top 3 disease respectively accounted for 35.4％,18.8％ and 6.1％,with a total incidence of 60.3％ of all the diseases.Conclusions Closer attention to the weak links in disease prevention and better prevention and treatment measures against the common disease among the recruits were the surest guarantee for the reduction of incidence and improvement of training results.

Objective To study and analyze the features and pattern of the common diseases occurred among recruits of a certain naval unit during training,so as to provide reference for the prevention of diseases.Methods Medical data files in the medical corps were sorted out,and were then classified according to the types of diseases,and finally were analyzed statistically.Results During recruit training,through outpatient service,inpatient service and medical tours or calls,there were 362 cases of various diseases,accounting for 22.3％ of all the recruits engaged in the recruit training.The top three diseases were:infection of the upper respiratory tract,with 128 cases,accounting for 7.88％,soft tissue injury of extremities with 68 cases,accounting for 4.18％ and oral diseases with 22 cases,accounting for 1.35％.From the perspective of diseases incidence,the top 3 disease respectively accounted for 35.4％,18.8％ and 6.1％,with a total incidence of 60.3％ of all the diseases.Conclusions Closer attention to the weak links in disease prevention and better prevention and treatment measures against the common disease among the recruits were the surest guarantee for the reduction of incidence and improvement of training results.

OBJECTIVETo apply the membrane separation process in the concentration process of Chuanxiong Chatiao granules and to lay the foundation for its industrialized application.

METHODThe type of membrane, the optimal pressure, the optimal temperature and the optimal detergent were selected by the single factor method. A comparative study was conducted between qualities of extracts from Chuanxiong Chatiao granules by new and traditional processes.

RESULTThe type of membrane was determined to be SMN-130A2350054. The optimal pressure was 1.7 MPa. The optimal temperature was 36 degrees C and the optimal detergent was 1% sodium polyphosphate. The qualities of extracts from Chuanxiong Chatiao granules by new and traditional processes showed no difference.

CONCLUSIONThe selected membrane separation process can effectively achieve concentration and save energy. The extracts from Chuanxiong Chatiao granules by the new process show no difference with traditional processes. Therefore, it provides basis for the industrialized application of Chuanxiong Chatiao granules.