Background and Aims:Acute pancreatitis(AP)is a common acute abdominal disease,with some patients progressing to moderately severe(MSAP)or severe acute pancreatitis(SAP).Secondary infection is a major determinant of prognosis.Carbapenem-resistant Acinetobacter baumannii(CRAB)has emerged as an important pathogen in AP,characterized by high drug resistance and mortality.This study aimed to comprehensively analyze the clinical characteristics,mortality risk factors,and antimicrobial resistance patterns of CRAB infection in MSAP/SAP patients,and to develop a predictive model.Methods:A retrospective cohort of 108 MSAP/SAP patients with CRAB infection admitted to Xiangya Hospital,Central South University,between January 2012 and August 2022 was analyzed.Clinical data,laboratory parameters,and antimicrobial susceptibility results were collected.Cox regression was performed to identify independent mortality risk factors,and a nomogram prediction model was constructed and validated.Results:The cohort comprised 108 patients(mean age 48 years,71.3%male).The leading etiologies were hypertriglyceridemia(61.1%)and biliary causes(33.3%).The most common infection sites were the pancreas/peripancreatic region(44.4%)and the lungs(43.5%).Overall mortality was 42.6%(46/108).Compared with survivors,deceased patients were older,more frequently had biliary etiology,ICU admission,mechanical ventilation,hemorrhage,and septic shock(all P<0.05).Multivariate Cox regression identified age>60 years(HR=6.694),hemorrhage(HR=4.466),septic shock(HR=4.495),and hemoglobin<80 g/L(HR=2.343)as independent predictors of death.Among 175 CRAB isolates,resistance rates exceeded 60%for most antibiotics,while tigecycline showed the lowest resistance(<40%).The nomogram model demonstrated excellent discrimination(C-index=0.897)and calibration,with an AUC of 0.897 for 90-day survival prediction.Conclusion:CRAB infection significantly worsens clinical outcomes in MSAP/SAP patients,with advanced age,hemorrhage,septic shock,and severe anemia as key mortality risk factors.The nomogram provides an effective tool for early identification of high-risk patients.Tailored therapeutic strategies,rational antibiotic use,and prevention of complications are essential to improving prognosis in this population.

Background and Aims:Acute pancreatitis(AP)is a common acute abdominal disease,with some patients progressing to moderately severe(MSAP)or severe acute pancreatitis(SAP).Secondary infection is a major determinant of prognosis.Carbapenem-resistant Acinetobacter baumannii(CRAB)has emerged as an important pathogen in AP,characterized by high drug resistance and mortality.This study aimed to comprehensively analyze the clinical characteristics,mortality risk factors,and antimicrobial resistance patterns of CRAB infection in MSAP/SAP patients,and to develop a predictive model.Methods:A retrospective cohort of 108 MSAP/SAP patients with CRAB infection admitted to Xiangya Hospital,Central South University,between January 2012 and August 2022 was analyzed.Clinical data,laboratory parameters,and antimicrobial susceptibility results were collected.Cox regression was performed to identify independent mortality risk factors,and a nomogram prediction model was constructed and validated.Results:The cohort comprised 108 patients(mean age 48 years,71.3%male).The leading etiologies were hypertriglyceridemia(61.1%)and biliary causes(33.3%).The most common infection sites were the pancreas/peripancreatic region(44.4%)and the lungs(43.5%).Overall mortality was 42.6%(46/108).Compared with survivors,deceased patients were older,more frequently had biliary etiology,ICU admission,mechanical ventilation,hemorrhage,and septic shock(all P<0.05).Multivariate Cox regression identified age>60 years(HR=6.694),hemorrhage(HR=4.466),septic shock(HR=4.495),and hemoglobin<80 g/L(HR=2.343)as independent predictors of death.Among 175 CRAB isolates,resistance rates exceeded 60%for most antibiotics,while tigecycline showed the lowest resistance(<40%).The nomogram model demonstrated excellent discrimination(C-index=0.897)and calibration,with an AUC of 0.897 for 90-day survival prediction.Conclusion:CRAB infection significantly worsens clinical outcomes in MSAP/SAP patients,with advanced age,hemorrhage,septic shock,and severe anemia as key mortality risk factors.The nomogram provides an effective tool for early identification of high-risk patients.Tailored therapeutic strategies,rational antibiotic use,and prevention of complications are essential to improving prognosis in this population.

Cassiae Semen is a substance with both edible and medicinal uses approved by the National Health Administration， and it is widely used in health food products in China. In this study， an information database of Cassiae Semen-based health food products was constructed， and the common patterns of functional claims， major raw materials， and dosage forms were analyzed. The Apriori algorithm and network method were used to analyze the association rules of high-frequency ingredients with the three major functional claims： Maintaining blood lipid （cholesterol/triglyceride） level， controlling fat， and relaxing bowel. Secondly， based on the positioning and regulatory requirements of health food and the recent research progress in Cassiae Semen， this paper analyzed the problems in technology review and product development from safety， function claim， and quality controllability. Finally， suggestions were put forward to promote the inheritance and carry forward China's traditional healthcare culture and the achievement of the Healthy China Initiative. These suggestions included classifying and optimizing the access management of health food， innovating the traditional healthcare function claims， and strengthening the quality system construction and information disclosure of post-marketing evaluation.

Objective : To study the effect of deep learning applied to the assisted diagnosis of radiolucent lesions and radiopaque lesions of the jaws in panoramic radiography and to reduce the missed diagnosis, with early screening to assist doctors to improve the diagnostic accuracy. Methods: This study was approved by the Ethics Committee of the West China Stomatological Hospital of Sichuan University. The YOLO v8m-p2 neural network model was constructed with 443 panoramic images as a subject to read. The labeled images were divided into 354 training sets, 45 verification sets, and 44 test sets, which were used for model training, verification, and testing. Accuracy, recall, F-1 score, G score, and mAP50 were used to evaluate the detection performance of the model. Results: 443 panoramic images covered the common benign lesions of the jaw, the number of radiolucent lesions of the jaw was 318, containing dentigerous cyst, odontogenic keratocyst, and ameloblastoma. The number of radiopaque lesions was 145, containing idiopathic osteosclerosis, odontoma, cementoma, and cemento-osseous dysplasia; the samples are well representative. The accuracy of the YOLO v8m-p2 neural network model in identifying jaw lesions was 0.887, and the recall, F-1 score, G score, and mAP50 were 0.860, 0.873, 0.873, and 0.863, respectively. The recall rates of dentigerous cyst, odontogenic keratocyst, and ameloblastoma were 0.833, 0.941, and 0.875, respectively. Conclusion YOLO v8m-p2 neural network model has good diagnostic performance in preliminary detection of radiolucent and radiopaque lesions of the jaws in panoramic radiography and multi-classification monitoring of radiolucent lesions of jaws, which can assist doctors to screen jaw diseases in panoramic radiography.

Objective: Schizophrenia (SCZ) is one of the most common and severe mental disorders. Modified electroconvulsive therapy (MECT) is the most effective therapy for all kinds of SCZ, and the underlying molecular mechanism remains unclear. This study is aim to detect the molecule mechanism by constructing the transcriptome dataset from SCZ patients treated with MECT and health controls (HCs). Methods: Transcriptome sequencing was performed on blood samples of 8 SCZ (BECT: before MECT; AECT: after MECT) and 8 HCs, weighted gene co-expression network analysis (WGCNA) was used to cluster the different expression genes, enrichment and protein-protein interaction (PPI) enrichment analysis were used to detect the related pathways. Results: Three gene modules (black, blue and turquoise) were significantly associated with MECT, enrichment analysis found that the long-term potentiation pathway was associated with MECT. PPI enrichment p-value of black, blue, turquoise module are 0.00127, <1×10-16 and 1.09×10-13, respectively. At the same time, EP300 is a key node in the PPI for genes in black module, which got from the transcriptome sequencing data. Conclusion It is suggested that the long-term potentiation pathways were associated with biological mechanism of MECT.

Objective: Schizophrenia (SCZ) is one of the most common and severe mental disorders. Modified electroconvulsive therapy (MECT) is the most effective therapy for all kinds of SCZ, and the underlying molecular mechanism remains unclear. This study is aim to detect the molecule mechanism by constructing the transcriptome dataset from SCZ patients treated with MECT and health controls (HCs). Methods: Transcriptome sequencing was performed on blood samples of 8 SCZ (BECT: before MECT; AECT: after MECT) and 8 HCs, weighted gene co-expression network analysis (WGCNA) was used to cluster the different expression genes, enrichment and protein-protein interaction (PPI) enrichment analysis were used to detect the related pathways. Results: Three gene modules (black, blue and turquoise) were significantly associated with MECT, enrichment analysis found that the long-term potentiation pathway was associated with MECT. PPI enrichment p-value of black, blue, turquoise module are 0.00127, <1×10-16 and 1.09×10-13, respectively. At the same time, EP300 is a key node in the PPI for genes in black module, which got from the transcriptome sequencing data. Conclusion It is suggested that the long-term potentiation pathways were associated with biological mechanism of MECT.

As the progress of population aging in China, the proportion of elderly population is increasing. Both chronic diseases and infectious diseases can threaten the health of the elderly. There are many kinds of infectious diseases, including vaccine preventable infectious diseases affecting the health of adults, such as influenza, pneumococcal diseases and herpes zoster. In addition, the newly emerged COVID-19 has caused a pandemic in the world, resulting the highest proportion of deaths occurred in the elderly and posing a serious threat to the health of the elderly. This paper mainly summarizes the prevention and control of vaccine preventable diseases and COVID-19 to which the elderly are susceptible, analyzes the infectious disease problems affecting the health of elderly population, and recommends countermeasures for the prevention and control of these diseases in elderly population.

Objective:To explore the influence of characteristics of green space on blood pressure control.Methods:Hypertensive patients who were managed by community health centers for one year and aged 35 years old and above were selected as the study subjects in Shenzhen. Multi-stage random sampling method was applied to select a representative sample of 1 200 patients. A total of 1 116 valid questionnaires were collected, with a response rate of 93.0%. From November 2019 to January 2020, well-structured questionnaire, physical examination and laboratory biochemical test were applied for information collection among the 1 116 participants. Binary logistic regression model was used to analyze the relationship between characteristics of green space and blood pressure control.Results:The rate of blood pressure control was 67.8%. Results of binary logistic regression analysis showed that after adjusting confounding factors, health supporting elements, such as fitness areas ( OR=1.678, 95% CI:1.231-2.288), collective exercise venues( OR=1.373, 95% CI:1.020-1.848), health knowledge promotion areas ( OR=1.416, 95% CI: 1.049-1.911) in green space, were significantly correlated with blood pressure control. Green space safetiness ( OR=1.010, 95% CI: 1.000-1.019), comfortableness ( OR=1.011, 95% CI: 1.001-1.021) and maintenance status ( OR=1.011, 95% CI: 1.001-1.021) also played a role. The rate of blood control among patients with exclusive green space was higher than that of patients without exclusive green space ( OR=1.333, 95% CI: 1.009-1.762). Conclusion:Health supporting elements, safety, comfort, maintenance of green space and exclusive green space play an important role in blood pressure controlling.

Objective:To assess the relationship between body mass index (BMI) and death risk of cardiovascular disease (CVD) in rural male population.Methods:22 282 men aged 40 years older in Tanghe county and Fenghuang county from the cohort of the "Prospective Study on Adult Behavior and Health Risk Factors in China" were selected as subjects of this study. Cox regression model was used to calculate the hazard ratios ( HRs) of the death of CVD during the follow-up period with different BMI groups at baseline. Results:The average follow-up period in the two counties was (19.1±8.7) years and 10 828 (48.6%) people died during the follow-up period. 4 504 deaths were attributed to CVD. Among the deaths of CVD, 1 279 cases died of ischemic heart disease (IHD), ischemic stroke (IS) died in 1 201, cases died of died of 1 317 hemorrhagic stroke (HS), other 707 cases. Compared to population with BMI<18 kg/m 2, Cox regression model (adjusting factors of region, age, nationality, education level, occupation, smoking, drinking, blood pressure, blood pressure, etc.) showed that people with BMI between 20-22 kg/m 2 had the lowest risk of CVD death ( HR=0.95, 95 %CI: 0.83-1.09). But the difference was not statistically significant among each BMI group ( P>0.05). The risk of IHD death was the lowest in the population with BMI between 20-22 kg/m 2 ( P<0.05) ( HR=0.64, 95 %CI: 0.52-0.80). There was no statistically significant difference between the risk of IHD death in the population with BMI≥24 kg/m 2 and that in the population with BMI<18 kg/m 2 ( P>0.05). There was no statistically significant difference between the risk of IS death and BMI ( P>0.05). The death risk of HS in the population with BMI between 18-24 kg/m 2 was higher than that in the population with BMI<18 kg/m 2 ( P<0.05). The death risk of the population with BMI between 26-28 kg/m 2 was the highest ( HR=1.88, 95 %CI:1.18-2.99). Conclusions:The mortality risk of CVD and IHD was the lowest in lean or normal weight group, and HS was higher in overweight group. Maintaining a reasonable weight can reduce the risk of death in patients with CVD.

Objective To explore the feasibility of removal of affected segments via laparoscopic surgery in patients with mild colorectal perforation. Methods The clinical data on sixty-one patients with colorectal perfo-ration who had been treated in our hospital between June 2006 and June 2016 were retrospectively analyzed. The patients were divided into an open surgery group(group OS,n=38)and a laparoscopic surgery group(group LS, n = 23). All the procedure-related data were collected and analyzed. P < 0.05 was considered statistically signifi-cant in this study. Results The volume of blood loss was smaller in group LS than in group OS[(100 ± 165)mL vs(200 ± 205)mL,P=0.032],hospital stay was shorter in group LS than in group OS[(7 ± 5.21)d vs.(10 ± 9.2)d ,P = 0.009],and rate of wound infection was lower in group LS than in group OS(4/23 vs. 13/38,P =0.039),while surgical duration was longer(213.7 ± 65.7 min vs. 173.5 ± 47.2 min,P = 0.047). There were no significant differences between the two groups in intraoperative blood transfusion[(0.8 ± 1.1)U vs.(0.4 ± 0.7)U , P=0.270],postoperative ICU stay[(2 ± 0.9)d vs.(2 ± 0.7)d,P=0.009],rate of postoperative complications 25/38 vs. 14/23),and hospitalization costs[(31 758 ± 29 283)yuan vs.(36 243 ± 27 584)yuan,P = 0.673]. Conclusions Laparoscopic colectomy is safe and feasible in the treatment of mild colorectal perforation.